Article
Engineering, Chemical
Francisca Jennifer Duarte de Oliveira, Moan Jefter Fernandes Costa, Pedro Henrique Sette-de-Souza, Diana Ferreira Gadelha de Araujo, Boniek Castillo Dutra Borges
Summary: This systematic review evaluated the antibacterial effect of adding dimethylaminohexadecyl methacrylate (DMAHDM) in dental adhesive systems. The results demonstrated the efficacy of DMAHDM in inhibiting bacterial growth through various approaches. Most studies showed no compromise in dentin shear bond strength, with exceptions. Long-term effectiveness was less reported, but no loss of antibacterial efficacy was observed after 30 days to 12 months. The studies highlighted the need for further research on biocompatibility and long-term performance.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Review
Chemistry, Medicinal
Ghulam Sarwar Khalid, Mohammad Hassan Hamrah, Elaha Somaya Ghafary, Sepideh Hosseini, Fateme Almasi
Summary: Studies have shown that Xanthorrhizol exhibits significant inhibitory effects on caries-causing bacteria, but it cannot selectively target the growth of cariogenic bacteria. Research exploring its potential as a drug for preventing and treating dental caries has shown promising results, but further work is needed in areas such as optimal dosage, in vitro and in vivo studies, and selective targeting of cariogenic bacteria.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Chemistry, Physical
Alison Clarin, Daphne Ho, Jana Soong, Cheryl Looi, Deepak Samuel Ipe, Santosh Kumar Tadakamadla
Summary: Researchers have developed novel nanocomposites by incorporating additional biomaterials with DMAHDM to reduce secondary caries, with improved antibacterial potency by adding MPC and AgNPs, and enhanced remineralization potential by adding NACP and PAMAM nanoparticles. Further clinical studies are needed to explore the antibacterial and remineralizing properties of these composites for clinical success.
Article
Biotechnology & Applied Microbiology
Louis Hardan, Rim Bourgi, Carlos Enrique Cuevas-Suarez, Monika Lukomska-Szymanska, Elizabeth Cornejo-Rios, Vincenzo Tosco, Riccardo Monterubbianesi, Sara Mancino, Ammar Eid, Davide Mancino, Naji Kharouf, Youssef Haikel
Summary: This study systematically reviewed the existing literature to evaluate the impact of disinfection procedures on bacterial colonization of dental impression materials. The meta-analysis showed that various disinfectants reduced the colony-forming units in different impression materials.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Youjing Qiu, Takashi Saito
Summary: The novel bioactive adhesive monomer CMET demonstrated low cytotoxicity and high odontogenic differentiation capacity on human dental pulp stem cells. In a rat pulp injury model, CMET induced continuous hard tissue bridge formation at the pulp exposure site, with a regular dentinal tubule pattern. These findings suggest that CMET may serve as a promising adjunctive for pulp-capping materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Infectious Diseases
Nansi Lopez-Valverde, Bruno Macedo-de-Sousa, Antonio Lopez-Valverde, Juan Manuel Ramirez
Summary: This study evaluated Ti implants coated with different antibacterial surfaces and found that they have better osseointegration capacity, but the quality of research methods and experimental models used can affect the reliability of the results.
Article
Dentistry, Oral Surgery & Medicine
Bina Yang, Bingqing Song, Jingou Liang, Xuedong Zhou, Biao Ren, Xian Peng, Qi Han, Mingyun Li, Lei Cheng
Summary: Previous studies have shown that there are microorganisms in the oral cavity that promote the occurrence of dental caries, but few studies have been conducted on anticaries materials for these 'core microbiome'. The DMAEM monomer has been found to have an inhibitory effect on the growth of Streptococcus mutans and saliva biofilm, but its effect on the core microbiome of caries needs further research.
Review
Chemistry, Physical
Florin Eggmann, Jonathan D. Hwang, Jose M. Ayub, Francis K. Mante
Summary: Head and neck cancers are a significant global health burden, and this systematic review evaluated the effect of irradiation on the adhesive performance of resin-based biomaterials. The analysis included 23 laboratory studies, which found that irradiation reduces bond strength and increases microleakage. The review highlights the need for further studies to evaluate adhesive materials and improve their performance.
Review
Cell Biology
Louis Hardan, Rim Bourgi, Carlos Enrique Cuevas-Suarez, Walter Devoto, Maciej Zarow, Paulo Monteiro, Natalia Jakubowicz, Amine El Zoghbi, Dariusz Skaba, Davide Mancino, Naji Kharouf, Youssef Haikel, Monika Lukomska-Szymanska
Summary: This study systematically reviewed the literature to evaluate the bonding performance of adhesive systems to dentin using different application modalities. It found that using alternative techniques or additional strategies during the application of adhesive systems can improve their bond strength to dentin.
Article
Dentistry, Oral Surgery & Medicine
Jiahui Zhang, Xi He, Shiyang Yu, Jiufu Zhu, Huimin Wang, Zilu Tian, Song Zhu, Zhanchen Cui
Summary: The study demonstrated that functional adhesives containing Ag/polydopamine-modified HA fillers possess excellent antibacterial and mineralization properties, along with good biocompatibility with cells. These adhesives have the potential to enhance the stability and durability of hybrid layers, prolonging the service life of dental restorations.
JOURNAL OF DENTISTRY
(2021)
Review
Multidisciplinary Sciences
Rita Teixeira-Santos, Marisa Gomes, Luciana C. Gomes, Filipe J. Mergulhao
Summary: The study found that surfaces containing modified CNTs, especially CNTs conjugated with different polymers, exhibited strong antimicrobial and anti-adhesive properties, protecting cells from protein adsorption. However, due to the unresolved toxicity of CNTs on the human body, they cannot yet compete with traditional strategies in fighting biofilms. This review may be helpful for the development of new engineered medical surfaces.
Review
Microbiology
Virginie Gazil, Octave Nadile Bandiaky, Emmanuelle Renard, Katia Idiri, Xavier Struillou, Assem Soueidan
Summary: The success rates of dental implants at 5 and 10 years are nearly 90%. The prevalence of peri-implant diseases, such as peri-implantitis and peri-implant mucositis, is significant. Recent studies using new generation sequencing methods have compared the microbiota of healthy and diseased periodontal and peri-implant sites, revealing distinct differences in diversity and composition. Understanding the characteristics of the peri-implant microbiota can optimize therapeutic strategies for peri-implant diseases.
Article
Dentistry, Oral Surgery & Medicine
Rana Alkattan, Subir Banerji, Sanjukta Deb
Summary: This study aimed to design a dentine bonding system (DBS) with an antimicrobial monomer and self-etching primers. The experimental results showed that the DBS had lower water sorption and polymerisation exotherm, formed a distinct hybrid layer, and exhibited higher bond strength and lower nanoleakage after water storage challenges. Additionally, the DBS demonstrated inhibitory activity against MMP.
Review
Medicine, General & Internal
Cornelia Melinda Adi Santoso, Fera Ketti, Taufan Bramantoro, Judit Zsuga, Attila Nagy
Summary: Good oral hygiene status, frequent tooth-brushing, and interdental cleaning are inversely associated with metabolic syndrome (MetS), but further longitudinal studies are needed to confirm these associations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Maria Contaldo, Alberta Lucchese, Antonio Romano, Fedora Della Vella, Dario Di Stasio, Rosario Serpico, Massimo Petruzzi
Summary: Studies have shown differences in oral microbiota composition between individuals with DS, healthy subjects, and those with other intellectual disabilities. However, data on the mycobiome and virobiome of DS are limited, indicating further research is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Lucas Peixoto de Araujo, Wellington Luiz de Oliveira da Rosa, Tiago Schlindvein de Araujo, Felipe Immich, Adriana Fernandes da Silva, Evando Piva
Summary: This systematic review and meta-analysis evaluated the necessity of placing an intraorifice barrier (IOB) in endodontically treated teeth (ETT). The results showed that placing an IOB can significantly reduce microleakage in ETT, and bioceramics seem to be the best available material for this purpose.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Microbiology
Marisa Castro Jara, Allison Carlos Assuncao Silva, Marina Ritter, Adriana Fernandes da Silva, Carolina Lambrecht Goncalves, Pedro Rassier dos Santos, Luciano Sisconetto Borja, Claudio Martin Pereira de Pereira, Patricia da Silva Nascente
Summary: The study explored the development of DHPM derivatives as alternative and prospective antimicrobial agents through antimicrobial activity testing.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. David, C. E. Cuevas-Suarez, G. C. de Cardoso, C. P. Isolan, R. R. de Moraes, W. L. O. da Rosa, E. A. Munchow, A. F. da Silva
Summary: This study evaluated the physical and biological properties of different types of flowable resin composites and their bonding ability to dentin. The results showed that chemical composition is an important factor influencing the behavior of the materials tested.
OPERATIVE DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Andressa Goicochea Moreira, Carlos Enrique Cuevas-Suarez, Juliana Silva Ribeiro, Julianne Bartz Maass, Evandro Piva, Rafael Ratto de Moraes, Marco Cicero Bottino, Giana da Silveira Lima
Summary: The incorporation of repairing capsules containing different monomers and polymerization modulators did not affect the properties of the material, but improved the fracture toughness and self-healing efficiency.
JOURNAL OF DENTISTRY
(2022)
Review
Biology
Mauro Schmitz Estivalet, Lucas Peixoto de Araujo, Felipe Immich, Adriana Fernandes da Silva, Nadia de Souza Ferreira, Wellington Luiz de Oliveira da Rosa, Evandro Piva
Summary: This study aimed to synthesize and map key concepts related to the bioactivity analysis of bioceramic-based root canal sealers through in vitro and in vivo studies. The results showed that common methods in vitro included mineralization potential, formation of carbonated apatite on the surface, and gene expression, while in vivo studies mainly utilized staining techniques and immunohistochemical tests to detect mineralization.
Review
Engineering, Chemical
Marcieli Dias Furtado, Felipe Immich, Wellington Luiz de Oliveira da Rosa, Evandro Piva, Adriana Fernandes da Silva
Summary: This study evaluated different bonding strategies for repairing aged resin composite restorations and found that better bonding can be achieved with air abrasion or diamond burs, as well as surface etching with phosphoric acid followed by application of adhesive system.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Article
Chemistry, Physical
Carlos Enrique Cuevas-Suarez, Eliseu Aldrighi Munchow, Christian Goncalves Schwarzbold, Josiane Kuhn Rutz, Adriana Fernandes da Silva, Evandro Piva
Summary: This study evaluated the properties of adhesive resins modified with different antioxidants as polymerization inhibitors. The results showed that adhesives modified with BHT and AA had lower degree of conversion, while the presence of QC resulted in color changes and higher yellowing index. The addition of GA reduced the cohesive strength of the materials. However, all adhesives demonstrated similar cell viability and translucency compared to the control. The use of alternative antioxidants showed potential for the development of dental adhesive resins without significant impairment of their properties.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Review
Engineering, Biomedical
Tiago Machado Da Silva, Felipe Immich, Tiago Schlindvein De Araujo, Rafael Guerra Lund, Adriana Fernandes Da Silva, Evandro Piva, Wellington Luiz De Oliveira Da Rosa
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Chemical
Carlos Enrique Cuevas-Suarez, Adriana Fernandes Da Silva, Alexsandro Dallegrave, Cesar Liberato Petzhold, Claudio Martin Pereira De Pereira, Wellington Luiz Oliveira Da Rosa, J. Eliezer Zamarripa-Calderon, Evandro Piva
Summary: This study examined the effect of unreacted substances of four universal adhesives on cell viability, taking into account different sample preparation protocols. It was found that disc-shaped specimens made with the adhesive material itself led to an overestimation of cell viability outcomes for the universal adhesives. CQ was identified as the most cytotoxic component among the analyzed substances.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Juliana S. Ribeiro, Samantha R. Xavier, Carlos E. Cuevas Suarez, Fernanda G. Pappen, Evandro Piva, Rafael G. Lund, Marco C. Bottino
Summary: This study evaluated the effects of incorporating halloysite nanotubes (HNTs) loaded with calcium hydroxide (CaOH2) or beta-tricalcium phosphate (beta-TCP) on the physicochemical and biological properties of an experimental resin-based dual-cured endodontic sealer. The results showed that the experimental sealers containing HNT_CaOH2 or HNT_beta-TCP exhibited antimicrobial effects and gradual release of calcium ions, without compromising the cytocompatibility or physicochemical properties of the sealers.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Lara Rodrigues Schneider, Andressa da Silva Barboza, Juliana Silva Ribeiro de Andrade, Daniela Coelho dos Santos, Carlos Enrique Cuevas-Suarez, Evandro Piva, Angela Diniz Campos, Rafael Guerra Lund
Summary: This study evaluated the antimicrobial activity and physicochemical properties of a new dual-cure endodontic sealer containing copaiba oil. Copaiba oil was characterized by gas chromatography and its minimum inhibitory concentration was determined. The antimicrobial activity of the sealers was evaluated by direct contact test, while the physicochemical properties were assessed through various tests. The sealers containing copaiba oil showed antimicrobial activity without compromising their physicochemical properties.
Article
Dentistry, Oral Surgery & Medicine
Fabiano Paiva Vieira, Alcides Gonini Junior, Evandro Piva, Hellen de Lacerda Oliveira, Wellington Luiz de Oliveira Da Rosa, Adriana Fernandes Da Silva, Rafael Pino Vitti, Cesar Henrique Zanchi, Sergio da Silva Cava
Summary: This study evaluated the physicochemical and biological properties of experimental resin-based calcium aluminate and calcium titanate materials for vital pulp therapy. The results showed that the dual-cured calcium aluminate material calcined at 800 degrees Celsius had similar properties to traditional materials in terms of its physicochemical and biological performance.
BRAZILIAN ORAL RESEARCH
(2022)
