Article
Plant Sciences
Zhi-Hong Xu, Robert B. Grossman, Yu-Feng Qiu, Yang Luo, Tian Lan, Xing-Wei Yang
Summary: In this study, 21 new polycyclic polyprenylated acylphloroglucinols (PPAPs) were isolated and characterized from Garcinia xanthochymus. The relative configuration of the C-30 stereocenter was determined using various methods, and the absolute configurations of the new compounds were assigned through spectroscopic analysis. The isolated PPAPs showed moderate antiproliferative activity, with some compounds inducing apoptosis and inhibiting cell migration in hepatocellular carcinoma cells by downregulating the STAT3 signaling pathway.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Analytical
Zhibo Song, Tao Chen, Shuo Wang, Cheng Shen, Hongmei Li, Aijing Li, Peipei Li, Yumei Ma, Zhi Chen, Yulin Li
Summary: In this study, an efficient strategy for the large-scale preparation of two minor polar polyphenols from Phyllanthus emblica L. has been established using macroporous resin column chromatography and high-temperature preparative high-speed counter-current chromatography. The combination of enrichment and separation steps provides a reliable method for obtaining compounds with high purity.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Biochemical Research Methods
Shanshan Sun, Xiulan Xin, Lijun Zhu, Liang Chen, Zhaochu Xu, Yufeng Liu
Summary: This study successfully extracted three phenolic acids and two flavonoids from the fruits of Sorbus pohuashanensis using HSCCC, with purities above 95%. These compounds have beneficial effects such as anti-inflammatory, anti-tussive, anti-asthmatic and anti-cancer properties.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Biochemical Research Methods
Shunjie Zhang, Haijun Chen, Xiaodie Deng, Hailu Chen, Chanjuan Guo, Li Wan, Aihua Peng, Lijuan Chen
Summary: Counter-current chromatography (CCC) is a widely used liquid-liquid separation technique, and high aspect ratio rectangular horizontal (RH) tubing has shown advantages in improving resolution and throughput. This study verifies the high stationary phase retention and throughput of RH tubing on a semi-preparative CCC apparatus, and successfully manufactures a lighter and larger volume semi preparative bobbin with thin-wall RH tubing.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Analytical
Denglang Zou, Yunbin Cui, Si Li, Duocheng Sang, Weimeng Liu, Tianshu Zhao, Xueli Gu, Tao Chen, Yulin Li
Summary: High-speed counter-current chromatography is a valuable method for purifying biosynthesized products, as demonstrated in this study where glycosylation products of Silybin B were successfully separated. The optimized system allowed for simultaneous purification of multiple glycosylation products with high purity levels, showcasing the potential of this technique in preparative separation of biosynthesis products.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Jinggui Nie, Danting Chen, Jing Ye, Yanbin Lu, Zhiyuan Dai
Summary: In this study, a preparative separation protocol for three terpenoids from Sargassum fusiforme was established using high-speed countercurrent chromatography combined with preparative high-performance liquid chromatography. The isolated compounds showed purities above 95% and their chemical structures were identified by H-1 and C-13 nuclear magnetic resonance spectroscopy.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Biochemical Research Methods
Yingying Tang, Jie Hao, Chen Fan, Xueli Cao
Summary: A preparative separation method for ferulic acid stereoisomers from wheat bran was successfully developed in this study. Different partition behavior of stereoisomers was influenced by proton affinity, deprotonation ability, and interaction site of hydrogen bond. The method showed potential for applications in the exploitation of ferulic acids and related phenolic acids from other resources.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Multidisciplinary
Ricardo Felipe Alexandre de Mello, Wandson B. de Souza Pinheiro, Jaisielle Kelem F. Benjamim, Francilia Campos de Siqueira, Renan Campos Chiste, Alberdan Silva Santos
Summary: The study introduced a highly efficient Prep-HSCCC method for isolating bioactive xanthones from a Garcinia mangostana extract, demonstrating high purity isolation and efficient scavenging of free radicals by the isolated compounds.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xiaowei Dong, Hongping Huang, Rong Wang, Shiyu Luo, Yahui Mi, Yuqing Pan, Wei Shen, Jiamin Cui, Xiaolong Hu, Xuexiang Cheng, Xinhong Shi, Hao Wang
Summary: In this study, phenolic compounds were successfully separated from Chrysanthemum morifolium cv. Fubaiju flowers, including flavonoid glycosides and quinic acid derivatives. The isolation was achieved by using high-speed counter-current chromatography and preparative high-performance liquid chromatography. The isolated compounds were evaluated for their protective effects on H2O2-induced oxidative damage in adult retinal pigment epithelial cells.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Zhibo Song, Tao Chen, Shuo Wang, Cheng Shen, Yumei Ma, Aijing Li, Zhi Chen, Yulin Li
Summary: An efficient strategy for large-scale preparation of five polar polyphenols from Phyllanthus emblica Linn has been established using preparative high-speed counter-current chromatography. The method involves enrichment with macroporous resin column chromatography, removal of ultra-polar impurities using liquid-liquid extraction, and separation using preparative high-speed counter-current chromatography.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Biochemical Research Methods
Qiqi Wang, Tao Chen, Yunbin Cui, Si Li, Xinhao Jiang, Guodong Zhao, Yulin Li, Denglang Zou
Summary: PZRCCC with liquid stationary phase and large-scale separation ability is suitable for final product purification in biosynthesis. In this study, glycosylation products of ellagic acid were successfully separated using PZRCCC, demonstrating its applicability for preparative separation of biosynthesis products.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Biochemistry & Molecular Biology
Artak E. Kostanyan, Andrey A. Voshkin
Summary: The study aims to further develop the theory of CLR DM CCC applied to preparative and industrial separations, where high-throughput operation is required. Large sample volumes can be loaded via continuous loading within a specified time. Equations are developed and presented in Mathcad software to simulate CLR DM CCC separations with specified sample loading durations.
Article
Biochemical Research Methods
Hepeng Li, Feiying Zhang, Qunying Jin, Tangjun Zhu
Summary: An improved closed-loop recycling counter-current chromatography (CLR CCC) method was developed for the separation and purification of cyclosporin D from fungus extract, achieving a purity of 95.2% after five cycles. Interestingly, cyclosporin D can be prepared using both conventional CCC and the improved method, but with varying efficiency.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Multidisciplinary
Yameng Wu, Jianhui Xie, Jielin Zeng, Rui Bai, Hui Zhang, Jizhong Yan
Summary: This study successfully isolated and purified four unstable compounds from the ethanol extract of Caesalpinia sappan L. using different chromatographic techniques. The structures of these compounds were determined using nuclear magnetic resonance. The results provided a theoretical basis for the quality assessment of Caesalpinia sappan L.
Article
Chemistry, Analytical
Xuan Sun, Long Chen, Huijiao Yan, Li Cui, Hidayat Hussain, Lei Xie, Jie Liu, Yujuan Jiang, Zhaoqing Meng, Guiyun Cao, Jeonghill Park, Daijie Wang
Summary: Paeonia lactiflora Pall. is a well-known classical herbal medicine with a history of over 1200 years in treating diseases. In this research, functional ingredients were purified using high-speed counter-current chromatography, and albiflorin was identified as a compound with strong antioxidant activity. The findings suggest that albiflorin has potential for treating diseases caused by oxidation.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Engineering, Chemical
Guoliang Liu, Yahui Cai, Hongye Yuan, Jinliang Zhang, Zunmin Zhang, Dan Zhao
Summary: Researchers have successfully synthesized 2D Zr-MOF nanosheets with desired water wettability and coated them on stainless steel mesh membranes, achieving excellent oil-water separation performance and corrosion resistance.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Engineering, Biomedical
Yun Gu, Jie Yang, Guang-Zhong Yang
Summary: In this work, we proposed an Occlusion-Aware Spatial Propagation model to address the challenge of pose estimation of suture threads in surgery. We resolved the challenging cases caused by self-intersection of threads by modeling the region connectivity, and handled the background occlusion with the guided spatial propagation mechanism. Experimental results demonstrated that our proposed method achieved superior accuracy compared to baseline methods, indicating the effectiveness of considering occlusion and employing spatial propagation in pose estimation. Our fully automated algorithm provides a general framework for pose estimation of suturing thread without the need for external simulation, and addresses the common occlusion problem in surgery, showing promise for future autonomy of robotic surgery.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Interdisciplinary Applications
Weihao Yu, Hao Zheng, Yun Gu, Fangfang Xie, Jie Yang, Jiayuan Sun, Guang-Zhong Yang
Summary: A graph-neural-network-based method is proposed to annotate bronchial trees extracted from CT images, providing fine-grained maps for intra-operative navigation. The proposed method tackles the challenge of sparse distribution and class imbalance in 3D image space by mapping branches to nodes in a graph space and assigning anatomical labels down to subsegmental level. It addresses the overlapping distribution problem of positional and morphological features by focusing on the relative position between sibling subsegments. The method achieves high accuracies for segmental and subsegmental node classification.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Hao Yang, Haoyuan Zhang, Dan Zhao
Summary: Covalent organic frameworks (COFs) are promising crystalline porous materials that can be finely adjusted in terms of structure and function. Recent research has focused on designing and preparing functional COF films using surface and interfacial chemistry. This Perspective outlines the recent advances in this area and discusses the current obstacles and opportunities in scaling up the preparation of functional COF films for industrial applications. The goal is to inspire the development of COF films with tailored structures and functionalities for diverse molecular separation processes.
Article
Computer Science, Artificial Intelligence
Hanxiao Zhang, Liang Chen, Xiao Gu, Minghui Zhang, Yulei Qin, Feng Yao, Zhexin Wang, Yun Gu, Guang-Zhong Yang
Summary: This study addresses the generalizability issues in lung nodule classification by constructing a sure-annotation dataset and proposing a collaborative learning framework. By integrating unsure-annotation data knowledge through nodule segmentation and malignancy score regression, the proposed approach achieves improved performance and trustworthy model reasoning.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Hongye Yuan, Kerui Li, Dongchen Shi, Hao Yang, Xin Yu, Weidong Fan, Pio John S. Buenconsejo, Dan Zhao
Summary: This study reports the facile fabrication of ultrathin (down to 20 nm) NUS-8 membranes in large-area (>200 cm(2)) with great homogeneity and texture along (00l) direction. The NUS-8 membranes show excellent rejections (>98%) towards various metal ions and dyes in aqueous separation due to the well-aligned structures. The study opens up novel perspectives for preparing ultrathin and large-area MOF membranes using the solution processability of MOFs.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Zhuo-Chen Ma, Jiahao Fan, Hesheng Wang, Weidong Chen, Guang-Zhong Yang, Bing Han
Summary: Microactuators are capable of converting external energy into specific mechanical motions autonomously. With varying feature sizes, microactuators offer numerous operation and control possibilities for miniaturized devices. Recent advancements in microfluidic techniques have revolutionized the fabrication, actuation, and functionalization of microactuators. This review comprehensively explores the systematic correlation between microactuator properties and microfluidic functions.
Article
Chemistry, Multidisciplinary
Wenli Xie, Hefeng Nian, Xueni Li, Jing Xu, Yu Chen, Zhinan Mei, Guangzhong Yang
Summary: Six previously unknown sulfur-containing amides were discovered in Glycosmis pentaphylla leaves. Their structures were determined using various techniques. These compounds showed anti-inflammatory and anti-proliferative activities, with compound 4 exhibiting significant inhibition of nitric oxide production in mouse macrophage cells.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Yunpan Ying, Dechao Wang, Dan Zhao
Summary: Two-dimensional material-based membranes have attracted increasing attention due to their distinct advantages in gas separation applications. However, challenges still exist in maintaining high separation performance under practical operating conditions. This article summarizes the development of these membranes in recent years, analyzes their advantages and shortcomings, and provides perspectives for future development. Efforts should be focused on developing large-area, robust membranes with stable performance in module devices. Standardizing test conditions is also recommended to fairly collect and compare the results of numerous studies.
CURRENT OPINION IN CHEMICAL ENGINEERING
(2023)
Review
Engineering, Multidisciplinary
Ziqi Yang, Zhongjie Wu, Shing Bo Peh, Yunpan Ying, Hao Yang, Dan Zhao
Summary: Mixed-matrix membranes (MMMs) combining porous materials and polymeric matrix have attracted considerable attention in gas separation. The tailorability and diversity of porous materials enable MMMs to have extendable functionalities and excellent separation performance. This review highlights the recent advances of employing metal-organic frameworks (MOFs) and metal-organic cages (MOCs) in MMMs fabrication and discusses the opportunities and challenges in the future development of MMMs.
Article
Chemistry, Multidisciplinary
Yun Zhao, Limin Huang, Dan Zhao, Jim Yang Lee
Summary: The sluggish kinetics of sulfur reactions on the cathode and the inadequate lithium deposition/stripping reversibility on the anode are successfully mitigated by using a single cathode modifier, In2Se3, which catalyses the polysulfide reactions on the cathode and improves lithium deposition/removal reversibility on the anode through the formation of a LiInS2/LiInSe2 containing solid electrolyte interface. This single modification approach shows excellent performance in Li-metal anode-free Li-S batteries, achieving 60% capacity retention and an average Coulombic efficiency of 98.27% after 160 cycles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Mathematics, Applied
Dan Zhao, Yongge Li, Qi Liu, Huikang Zhang, Yong Xu
Summary: In this paper, the authors use a class of generalized Duffing-type systems to reveal three mechanisms for the occurrence of extreme events. These mechanisms include the effect of very large excitation, the influence of bifurcation structures, and the impact of rare attractors. The results provide guidance for further prediction and avoidance of extreme events.
Review
Chemistry, Inorganic & Nuclear
Ting Chen, Dan Zhao
Summary: Metal-organic frameworks (MOFs) are porous crystalline materials constructed by metal clusters and organic linkers. Recent research has focused on the development of engineered forms of MOFs, particularly MOF-based membranes for molecular separations. This review highlights the advances in post-synthetic modification of MOFs and their membranes for enhanced separation performance. Post-synthetic modification methods are categorized and examples of modified MOF membranes are discussed. The contributions of post-synthetic modification to improved molecular separation performance are emphasized, along with the challenges and opportunities for practical applications of MOF membranes.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Engineering, Biomedical
Xinmiao Lan, Jie Zhong, Regina Huang, Yuhan Liu, Xiaowei Ma, Xuan Li, Dan Zhao, Guangchao Qing, Yuxuan Zhang, Lu Liu, Jinjin Wang, Xu Ma, Ting Luo, Weisheng Guo, Yuji Wang, Li-Li Li, Yu-Xiong Su, Xing-Jie Liang
Summary: Antimicrobial peptides (AMPs), a class of natural and synthetic oligopeptides, have shown potential in obtaining new therapeutic agents with improved properties. Self-assembled AMPs have become a hot topic for biomedical applications due to their diverse forms and advantages, such as stability and biocompatibility.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Tae Hyun Park, Byeonggwan Kim, Seunggun Yu, Youjin Park, Jin Woo Oh, Taebin Kim, Nara Kim, Yeonji Kim, Dan Zhao, Zia Ullah Khan, Samuel Lienemann, Xavier Crispin, Klas Tybrandt, Cheolmin Park, Seong Chan Jun
Summary: Researchers have developed a fully stretchable ITESC with stable high-performance electrolyte and stretchable gold nanowire electrodes for wearable heat harvesting devices.
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
