Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 41, Issue 1-2, Pages 35-45Publisher
KARGER
DOI: 10.1159/000440697
Keywords
Alzheimer's disease; Prevention; Risk factors; Cognitive decline; Hypercholesterolemia
Categories
Ask authors/readers for more resources
Background: The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer's disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. Methods: We used linear regression models to assess associations of APOE e4 with cognitive performance in a population-based cohort study (n = 1,434) and in a cohort of patients with coronary heart disease (n = 366), and restricted cubic splines to explore dose-response relationships between serum cholesterol levels and cognition depending on APOE polymorphism. Results: The association of APOE e4 with cognitive function was strongly amplified in the presence of hypercholesterolemia and cardiovascular disease in both independent cohorts; hypercholesterolemia was associated with cognitive function only among APOE e4 carriers in the presence of cardiovascular disease. The interaction effect between APOE genotype and hypercholesterolemia was statistically significant in both cohorts. Conclusions: The detrimental effects of APOE e4 polymorphism on cognition may strongly depend on modifiable risk factors. (C) 2015 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available