Article
Chemistry, Physical
Aditi Prabhune, Ranjan Dey
Summary: Deep Eutectic Solvents (DESs) have emerged as potential alternatives to conventional solvents in many industrial applications due to their safety, greenness, ease of preparation and wide range of applications.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Yang Zhou, Ya-Jiao Wu, Lei Wang, Juan Han, Jia-Cong Wu, Chun-Mei Li, Yun Wang
Summary: The study focused on using natural deep eutectic solvent (NADES) to improve enzyme stability, finding that the enhanced stability of carbonic anhydrase (CA) was due to the presence of a three-dimensional hydrogen bonding network, rather than the individual or synergistic effect of betaine and glyceride.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Ahlem Mnasri, Hatem Dhaouadi, Ramzi Khiari, Sami Halila, Evelyne Mauret
Summary: This study investigated the effects of Deep Eutectic Solvents (DES) on the structure of cellulose fibers, focusing on the induced fibrillation phenomena. The results showed that DES treatment could enhance the mechanical properties of resulting papers without significantly modifying the chemical composition, crystallinity, and degree of polymerisation of cellulose. This suggests that DES treatment can be considered as a soft and green chemical refining method for cellulose microfibrillation.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Valentina Busic, Maja Molnar, Vice Tomicic, Dalia Bozanovic, Igor Jerkovic, Dajana Gaso-Sokac
Summary: The study aimed to explore eutectic solvents as a greener alternative for conventional solvents in quaternization reactions, in accordance with green chemistry principles. The reactions using substituted phenacyl bromides and isonicotinamide under different synthetic approaches showed that microwave-assisted organic reactions yielded the highest product yields.
Article
Chemistry, Multidisciplinary
Maninder Meenu, Vasudha Bansal, Sudha Rana, Nitya Sharma, Vinod Kumar, Vaishali Arora, Monika Garg
Summary: Anthocyanins are extracted using alternative solvents such as ionic liquids, deep eutectic solvents, and natural deep eutectic solvents, which are more environmentally friendly and efficient compared to conventional solvents. Acid-based deep eutectic solvents with 20-30% water content showed the highest anthocyanin extraction yield. Ultrasonic-assisted extraction was the most common and efficient method, and DES-based extracts exhibited the highest stability and antioxidant activity. Fruits and their by-products are the most commonly used samples, while cereal and legumes are less explored.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Environmental Sciences
Willyan Araujo da Costa, Vanessa Freire de Franca, Layanny Samara da Silva Souza, Adrielly Silva Albuquerque de Andrade, Demetrius Antonio Machado de Araujo, Edilene Dantas Teles Moreira, Liliana Fatima Bezerra Lira Pontes
Summary: The search for new analytical methods in green analytical chemistry aims to address environmental issues. Green solvents, particularly deep eutectic solvents (DESs), have been identified as promising substitutes for dangerous organic solvents. This study investigated the physical-chemical and ecotoxicological properties of seven different DESs and found that their properties are influenced by the chemical structure of their precursors. These findings provide new insights into the conscious usage of DESs in green analytical chemistry.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Ke Xue, Dingchao Fan, Xiang Wang, Zihao Dong, Zhaoyou Zhu, Peizhe Cui, Fanqing Meng, Yinglong Wang, Jianguang Qi
Summary: Due to the increasing scarcity of lithium resources, the recovery of lithium ions from water resources is an urgent problem. This paper proposes an environmentally friendly liquid-liquid extraction (LLE) process for lithium ion recovery. Nine hydrophobic deep eutectic solvents (HDESs) were formed using menthol (DLM) as a hydrogen bond acceptor (HBA) and octanoic acid, decanoic acid, and lauric acid (LA) as hydrogen bond donors (HBDs). HDESs synthesized with DLM and LA showed the best effect and were selected for the lithium extraction experiment. The single extraction efficiency of lithium ions was 80.69%, with optimized parameters such as rotational speed, equilibrium time, pH, molar ratio, and initial concentration.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Review
Chemistry, Analytical
Alvaro Santana-Mayor, Ruth Rodriguez-Ramos, Antonio Herrera-Herrera, Barbara Socas-Rodriguez, Miguel Angel Rodriguez-Delgado
Summary: The development of sustainable chemistry has led to the emergence of new materials, with deep eutectic solvents (DESs) as a promising non-toxic alternative to toxic organic solvents, seeing a significant increase in their applications in analytical chemistry in recent years. The vast amount of information generated from studies associated with DESs needs continuous revision.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Green & Sustainable Science & Technology
Jun Cao, Erzheng Su
Summary: The discovery of hydrophobic deep eutectic solvents (HDESs) with good solvation abilities has expanded their application scope. HDESs show promising applications in fields such as food safety, environmental protection, biocatalysis, energy utilization, material modification, and pharmaceuticals.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Chemistry, Physical
Shaina Joarder, Divyam Bansal, Harshvardhan Meena, Neha Kaushik, Jaya Tomar, Kamlesh Kumari, Indra Bahadur, Eun Ha Choi, Nagendra Kumar Kaushik, Prashant Singh
Summary: In the past decade, deep eutectic solvents (DESs) have been widely used as green solvents due to their advantages over traditional organic solvents and ionic liquids. DESs have been applied in various fields such as biotechnology, nanotechnology, synthesis, and catalysis. However, there is still uncertainty about their toxicity and conflicting reports on their biocompatibility. This review focuses on the catalytic potential of DESs and discusses their biocompatibility on different organisms.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Environmental
Chun-Chi Chen, Yen -Hui Huang, Jia-Yu Fang
Summary: The study demonstrates that hydrophobic deep eutectic solvents (DESs) are efficient in eliminating hydrophilic VOCs due to their high absorption capacity and favorable gas-to-liquid mass transfer. Among the DESs explored, the one containing thymol and decanoic acid in a 1:1 molar ratio exhibits the highest acetone absorption capacity, showing the key role of hydrogen bonding interaction in achieving superior solubility of acetone in DESs. The absorbed acetone can be easily removed from the DESs, making the process economically and ecologically beneficial for hydrophilic VOC elimination.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xinyue Wang, Yijie Sheng, Haiyang Cui, Jie Qiao, Yibo Song, Xiujuan Li, He Huang
Summary: This study developed a protein engineering strategy called corner engineering to tailor enzyme resistance towards deep eutectic solvents (DESs) and high temperatures. The results demonstrated the generality of this strategy and identified the key factors influencing enzyme resistance and thermostability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Analytical
Luana Bastos Santos, Rosivan Santos Assis, Jeferson Alves Barreto, Marcos Almeida Bezerra, Cleber Galvao Novaes, Valfredo Azevedo Lemos
Summary: In recent years, there has been a significant increase in the search for green chemistry principles in analytical methods. Solvents play a crucial role in green analytical chemistry, and certain criteria must be met for a solvent to be considered green, including availability, low toxicity, biodegradability, and low cost. However, the availability of green solvents is currently limited. Deep eutectic solvents (DESs) have emerged as a new and promising alternative to traditional solvents, attracting attention for their eco-friendly, inexpensive, and easily obtainable characteristics. This work provides a critical review of the use of DESs in liquid-phase microextraction (LPME) and their contributions to green chemistry.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jeonghui Kim, Yeoheung Yoon, Seong K. Kim, Seungyoung Park, Wooseok Song, Sung Myung, Ha-Kyun Jung, Sun Sook Lee, Dae Ho Yoon, Ki-Seok An
Summary: 2D transition metal carbides and nitrides, known as MXenes, are typically synthesized and delaminated in different solutions, but chemical treatments in solution can affect their structures and properties. By utilizing DESs, long-term stable dispersion of Ti3C2Tx nanosheets is achieved, preventing oxidation and enhancing performance as electrodes for electrochemical capacitors.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Yu Chen, Fuguang Zhang, Haiyang Sun, Yi Chang, Ziyang Zhang, Zhenghui Liu, Mingshuai Yang
Summary: A new concept of green solvents called superlong supercooling solvents (SSSs) is proposed, which are metastable liquid solvents that can be used at temperatures around or slightly higher than room temperature before condensing after a superlong time. SSSs can serve as green alternatives to water, supercritical fluids, ionic liquids, and deep eutectic solvents (DESs).
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Chemical
Shahidah Nusailah Rashid, Adeeb Hayyan, Maan Hayyan, Mohd Ali Hashim, Amal A. M. Elgharbawy, Fazrizatul Shakilla Sani, Wan Jefrey Basirun, Vannajan Sanghiran Lee, Yatimah Alias, Alaa Kareem Mohammed, Mohamed E. S. Mirghani, M. Y. Zulkifli, Maher Rageh
Summary: This study investigates deep eutectic solvents (DESs) as potential media for enzymatic hydrolysis, examining the physicochemical properties of ammonium and phosphonium-based DESs at different molar ratios and their eutectic points. The results show that ternary DES systems could be viable lipase activators in hydrolysis reactions, with the eutectic points highly influenced by temperature variations.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2021)
Review
Chemistry, Multidisciplinary
Mohamad Hamdi Zainal-Abidin, Maan Hayyan, Won Fen Wong
Summary: Deep eutectic solvents (DESs) are a promising category of green solvents with biocompatibility and tunable properties. Hydrophobic DESs (HDESs), a subclass of traditional DESs, are considered to address stability issues when in contact with water. Although HDESs remain briefly addressed in the literature, they have been widely studied for the isolation and extraction of various compounds.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Mohamad Hamdi Zainal-Abidin, Maan Hayyan, Gek Cheng Ngoh, Won Fen Wong, Tugba Taskin Tok
Summary: Deep eutectic solvents (DESs) are novel 'green' solvents that have gained interest for their biocompatibility, stability, biodegradability, low volatility, and non-flammability. In this study, graphene functionalized with DESs exhibited high drug loading efficiency and showed destructive effects against cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Sharifah Shahira Syed Putra, Wan Jefrey Basirun, Amal A. M. Elgharbawy, Adeeb Hayyan, Maan Hayyan, Mohammed Alhaji Mohammed
Summary: This study successfully immobilized Candida Rugosa lipase using natural deep eutectic solvent and nanocellulose, enhancing its efficiency and stability in treating contaminants in edible oils.
MOLECULAR CATALYSIS
(2022)
Editorial Material
Pharmacology & Pharmacy
Maan Hayyan
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Energy & Fuels
Maan Hayyan, Adeeb Hayyan, Asyraf Danial M. Hafizi, Wan Jeffrey Basirun, Andrew T. H. Yeow, M. Zulhaziman M. Salleh, Hens Saputra, Jehad Saleh, Khaled H. Alkandari, Mohd Ali Hashim, Mohammed A. Alsaadi
Summary: This study explores the physicochemical properties of phosphonium-based deep eutectic solvents (DESs) and their potential as high-performance electrolytes in metal-air batteries. The study investigates the temperature-dependent properties of DESs, including freezing point, density, viscosity, surface tension, and conductivity. The electrochemical characteristics of a Zn-air battery with DES electrolyte, such as cell voltage, power density, and current limit, are also studied. The research highlights the dependence of the electrochemical and physicochemical profiles of phosphonium-based DESs on the salt-to-hydrogen bond donor molar ratio.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2023)
Review
Food Science & Technology
Sharifah Shahira Putra, Wan Jefrey Basirun, Amal A. M. Elgharbawy, Maan Hayyan, Waleed Al Abdulmonem, Abdullah S. M. Aljohani, Adeeb Hayyan
Summary: 3-MCPD is a common food contaminant in processed oils formed during the deodorization step of edible oil refining process. It has been detected in various food products and can cause kidney and testicular damage. This review provides an overview of its properties, occurrence, precursors, formation mechanism, toxicity, quantification methods, and mitigation strategies, highlighting the applicability, efficiency, and issues encountered during analysis. It elucidates the significance of 3-MCPDs and their food safety implications.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Review
Biochemistry & Molecular Biology
Vaisnevee Sugumar, Maan Hayyan, Priya Madhavan, Won Fen Wong, Chung Yeng Looi
Summary: The use of transdermal delivery system as an alternative to conventional oral or injectable routes has gained recognition due to its non-invasive and easily adaptable nature. However, the stratum corneum of the skin poses a barrier for large molecules like insulin. Various chemical enhancers have been proposed to increase the permeability of the stratum corneum or the full epidermis. This review discusses the recent progress in the development of chemical enhancers for transdermal insulin delivery and compares them to other therapeutical drugs.
Review
Engineering, Environmental
Amirah Azzouz, Maan Hayyan
Summary: Deep eutectic solvents (DESs) have attracted significant interest in fields such as nanotechnology due to their beneficial characteristics and potential to replace conventional agents with higher environmental impacts. Research studies have demonstrated the promise of DESs in improving efficiency and sustainability in nano-scale applications. Therefore, a comprehensive review of the recent advances in these fields is crucial.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Mohamad Hamdi Zainal-Abidin, Maan Hayyan, Juan Matmin, Abdo Mohammed Al-Fakih, Naharullah Jamaluddin, Wan M. Asyraf Wan Mahmood, Roswanira Abdul Wahab, Faizuan Abdullah
Summary: The field of green technology is rapidly evolving, and deep eutectic solvents (DESs) are emerging as potential alternatives to traditional compounds. Within DESs, magnetic DESs (MagDESs) are gaining attention due to their unique magnetic properties. These properties, along with their stability and compatibility, make MagDESs suitable for various applications such as magnetic separation and purification.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Engineering, Environmental
Amirah Azzouz, Maan Hayyan
Summary: Recently, deep eutectic solvents (DESs) have attracted attention as a greener alternative to conventional volatile organic compounds and even ionic liquids. However, the evaluation of their biodegradability and environmental impact is still limited. This work highlights the research efforts to date concerning DES biodegradability and emphasizes the importance of considering their biosafety and environmental impact for large-scale application in various industries.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Review
Green & Sustainable Science & Technology
Raiyan Al-Farsi, Maan Hayyan
Summary: Deep eutectic solvents (DESs) have promising applications in renewable energy technologies, serving as potential replacements for conventional liquids. They play crucial roles in solar energy and energy storage technologies, enhancing the efficiency of renewable energy systems and devices.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Proceedings Paper
Engineering, Industrial
Abdullah Al Habsi, Maan Hayyan, Hisham Al Riyami, Ahmed Al Omairi
Summary: Countries worldwide have introduced generation mix strategies to meet the rapid increase of demand, with renewable energy sources being the attractive and optimal solution. However, the increase of renewable energy sources may lead to reduced system inertia and increased frequency rate of change. This research aims to evaluate system inertia and define the maximum penetration of renewable energy sources.
2022 IEEE 31ST INTERNATIONAL SYMPOSIUM ON INDUSTRIAL ELECTRONICS (ISIE)
(2022)
Meeting Abstract
Chemistry, Applied
Adeeb Hayyan, Mohamed Hadj-Kali, Maan Hayyan, Ainul F. Kamarudin, Hanee Hizaddin, Emad Ali, Mohd Ali Hashim
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
Article
Engineering, Environmental
Ahmed Halilu, Maan Hayyan, Mohamed Kheireddine Aroua, Rozita Yusoff, Hanee F. Hizaddin, Wan Jefrey Basirun
Summary: The study introduces a novel pseudocapacitive Fe/Ru-SiMWCNT nanofluid with enhanced O-2 and CO2 adsorption capability, leading to stable generation of O-2(center dot-) and efficient conversion to C2O62-.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
