PCSK9 at the crossroad of cholesterol metabolism and immune function during infections

Oxidized low-density lipoproteins and lectin-like oxidized LDL receptor-1 are positively associated to PCSK9 in type 2 diabetes mellitus

(2016) Y. Nekaies et al.   ATHEROSCLEROSIS

Role of lipoproteins and proprotein convertase subtilisin/kexin type 9 in endotoxin clearance in sepsis

(2016) Keith R. Walley   Current Opinion in Critical Care

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis

(2016) Dhruva J. Dwivedi et al.   SHOCK

Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor

(2016) Elena Topchiy et al.   PLoS One

Role of lipid microdomains in TLR-mediated signalling

(2015) Jean-Marie Ruysschaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation

(2015) Steve Poirier et al.   Cell Reports

Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis

(2015) Sang Hoon Lee et al.   Biomed Research International

PCSK9 and LDLR degradation

(2014) Thomas A. Lagace   CURRENT OPINION IN LIPIDOLOGY

Sepsis: Current Dogma and New Perspectives

(2014) Clifford S. Deutschman et al.   IMMUNITY

Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation

(2014) Hong-Bo Xiao et al.   Pharmacological Reports

PCSK9 is a critical regulator of the innate immune response and septic shock outcome

(2014) K. R. Walley et al.   Science Translational Medicine

Reduction of Immunocompetent T Cells Followed by Prolonged Lymphopenia in Severe Sepsis in the Elderly*

(2013) Shigeaki Inoue et al.   CRITICAL CARE MEDICINE

Potential of Proprotein Convertase Subtilisin/Kexin Type 9 Based Therapeutics

(2013) Evan A. Stein et al.   Current Atherosclerosis Reports

Proprotein convertase subtilisin/kexin type 9 potentially influences cholesterol uptake in macrophages and reverse cholesterol transport

(2013) Li Shen et al.   FEBS LETTERS

Raftlin: a New Biomarker in Human Sepsis

(2013) Wonhwa Lee et al.   INFLAMMATION

Statins as Modulators of Regulatory T-Cell Biology

(2013) David A. Forero-Peña et al.   MEDIATORS OF INFLAMMATION

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

(2013) Maryssa Canuel et al.   PLoS One

Increased Cholesterol Content in Gammadelta (γδ) T Lymphocytes Differentially Regulates Their Activation

(2013) Hsin-Yuan Cheng et al.   PLoS One

LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus

(2013) D. Finkelshtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incidence and long-term outcome of sepsis on general wards and in an ICU at the General Hospital of Vienna: an observational cohort study

(2013) Thomas Stiermaier et al.   WIENER KLINISCHE WOCHENSCHRIFT

Bacterial Colonization of Host Cells in the Absence of Cholesterol

(2013) Stacey D. Gilk et al.   PLoS Pathogens

Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases

(2013) Athina Savva et al.   Frontiers in Immunology

Increased Expression of LDL Receptor-Related Protein 1 during Human Cytomegalovirus Infection Reduces Virion Cholesterol and Infectivity

(2012) Nicole Gudleski-O'Regan et al.   Cell Host & Microbe

Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes

(2012) Greg S Martin   Expert Review of Anti-Infective Therapy

Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice

(2012) Haruna Miyazawa et al.   Lipids in Health and Disease

Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies

(2012) Wijtske Annema et al.   Nutrition & Metabolism

Crosstalk between reverse cholesterol transport and innate immunity

(2012) Kathleen M. Azzam et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

PP-019 Plasma lipids levels in patients with acute bacterial infections

(2011) M. Nassaji et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective)

(2011) R. Daniels   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Chlamydia pneumoniae binds to the lectin-like oxidized LDL receptor for infection of endothelial cells

(2011) Lee Ann Campbell et al.   MICROBES AND INFECTION

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis

(2011) Hugues Ouellet et al.   TRENDS IN MICROBIOLOGY

Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

(2010) Bin Dong et al.   JOURNAL OF LIPID RESEARCH

Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome

(2009) Ynske P.M. van der Meer-Janssen et al.   PROGRESS IN LIPID RESEARCH

Inflammation stimulates the expression of PCSK9

(2008) Kenneth R. Feingold et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling

(2008) Jérome Terrand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants

(2008) Benjamin E. Steinberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors

(2008) Li Li et al.   JOURNAL OF LIPID RESEARCH

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

(2008) James A. Russell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

(2008) D.-W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA