Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A2A Receptor Involvement

Effects of Glucosamine and Nucleotide Association on Fibroblast: Extracellular Matrix Gene Expression

(2017) A. Avantaggiato et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The Effect of Polydeoxyribonucleotide on Ischemic Rat Skin Flap Survival

(2015) Dong Won Lee et al.   ANNALS OF PLASTIC SURGERY

Experimentally induced cartilage degeneration treated by pulsed electromagnetic field stimulation; an in vitro study on bovine cartilage

(2015) Francesca Veronesi et al.   BMC MUSCULOSKELETAL DISORDERS

Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2

(2015) Aránzazu Mediero et al.   FASEB JOURNAL

Effectiveness of polydeoxyribonucleotide injection versus normal saline injection for treatment of chronic plantar fasciitis: a prospective randomised clinical trial

(2015) Jae Kwang Kim et al.   INTERNATIONAL ORTHOPAEDICS

Multi-Layered Scaffolds for Osteochondral Tissue Engineering: In Vitro Response of Co-Cultured Human Mesenchymal Stem Cells

(2015) Sofia Amadori et al.   MACROMOLECULAR BIOSCIENCE

Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

(2015) Miguel Perez-Aso et al.   ARTHRITIS RESEARCH & THERAPY

Brief Report: Methotrexate Prevents Wear Particle-Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2AReceptor

(2015) Aránzazu Mediero et al.   Arthritis & Rheumatology

Inhibition of small HA fragment activity and stimulation of A2A adenosine receptor pathway limit apoptosis and reduce cartilage damage in experimental arthritis

(2014) Giuseppe M. Campo et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Effect of PDRN, an Adenosine Receptor A2AAgonist, on the Healing of Chronic Diabetic Foot Ulcers: Results of a Clinical Trial

(2014) Francesco Squadrito et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of Polydeoxyribonucleotide in the Treatment of Pressure Ulcers

(2014) Jung Yoon Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

In vivo effect of two different pulsed electromagnetic field frequencies on osteoarthritis

(2014) F. Veronesi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A randomized double-blind clinical trial on the treatment of knee osteoarthritis: The efficacy of polynucleotides compared to standard hyaluronian viscosupplementation

(2014) Laura S. Giarratana et al.   KNEE

Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study

(2014) Giovanni De Caridi et al.   International Wound Journal

Ultrasound-guided Prolotherapy with Polydeoxyribonucleotide Sodium in Ischiofemoral Impingement Syndrome

(2014) Won-Joong Kim et al.   Pain Practice

Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation?

(2013) Milena Fini et al.   TISSUE ENGINEERING PART B-REVIEWS

Protective effects of polydeoxyribonucleotides on cartilage degradation in experimental cultures

(2012) Luisa Gennero et al.   CELL BIOCHEMISTRY AND FUNCTION

Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis

(2012) Alessandra Bitto et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A2A receptor

(2011) Alessandra Bitto et al.   ARTHRITIS AND RHEUMATISM

Chondroprotective effects of pulsed electromagnetic fields on human cartilage explants

(2011) Alessia Ongaro et al.   BIOELECTROMAGNETICS

A novel composition for in vitro and in vivo regeneration of skin and connective tissues

(2011) Luisa Gennero et al.   CELL BIOCHEMISTRY AND FUNCTION

Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E2and cytokine release in human osteoarthritic synovial fibroblasts

(2011) A. Ongaro et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regenerative potential of glycosaminoglycans for skin and bone

(2011) Juliane Salbach et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps

(2011) Francesca Polito et al.   JOURNAL OF VASCULAR SURGERY

Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease and Multiorgan Failure after Stem Cell Transplantation: A Multicenter, Randomized, Dose-Finding Trial

(2010) Paul G. Richardson et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Efficacy of intra-articular polynucleotides in the treatment of knee osteoarthritis: a randomized, double-blind clinical trial

(2010) Roberto Vanelli et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice

(2010) Domenica Altavilla et al.   SURGERY

Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings

(2008) Margaret A. Fonder et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease

(2008) Alessandra Bitto et al.   JOURNAL OF VASCULAR SURGERY

Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts

(2008) M. De Mattei et al.   OSTEOARTHRITIS AND CARTILAGE

Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse

(2008) Mariarosaria Galeano et al.   WOUND REPAIR AND REGENERATION