Article
Cell Biology
Francesco Paduano, Elisabetta Aiello, Paul Roy Cooper, Benedetta Marrelli, Irina Makeeva, Mohammad Islam, Gianrico Spagnuolo, Davide Maged, Danila De Vito, Marco Tatullo
Summary: Dental stem cells have the potential to differentiate into various cell types and can revert back to a stem-like state after osteogenic differentiation, showing a greater potential for further differentiation. The ability to control dedifferentiation of DSCs under physiological conditions could enhance their therapeutic potential in bone tissue engineering.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Oscar O. Solis-Castro, Marcelo N. Rivolta, Fiona M. Boissonade
Summary: Evidence suggests that dental-related stem cells (DRSCs) have the potential for ectodermal lineage differentiation and can be used in the treatment of neurodegenerative diseases and nerve injuries. However, there are limitations in current research, such as the reliance on detecting neural crest markers to classify DRSCs as NCSCs and the lack of studies proving their improved neuro-glial differentiation or applicability in relevant models. Furthermore, existing protocols need to meet manufacturing standards for clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Peishan Li, Qianmin Ou, Songtao Shi, Changshun Shao
Summary: Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and can be used for the treatment of autoimmune diseases and other chronic disorders. Dental stem cells (DSCs) have remarkable immunomodulatory properties and have therapeutic effects on systemic inflammatory diseases. MSCs derived from nondental tissues, such as the umbilical cord, also show benefits in the management of periodontitis in preclinical studies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Duaa Abuarqoub, Sofia Adwan, Rand Zaza, Suha Wehaibi, Nazneen Aslam, Hanan Jafar, Nidal Qinnah, Abdalla Awidi
Summary: Diabetes Mellitus Type 1 is an autoimmune disease that destroys insulin-producing cells, leading to hyperglycemia. This study examined the differentiation potential of dental stem cells (SCAP) and bone-marrow-derived stem cells (BM-MSCs) into functional islet cell aggregates (ICAs). The results showed that both types of stem cells successfully differentiated into beta-cell-like cells.
Review
Biochemistry & Molecular Biology
Keiji Masuda, Xu Han, Hiroki Kato, Hiroshi Sato, Yu Zhang, Xiao Sun, Yuta Hirofuji, Haruyoshi Yamaza, Aya Yamada, Satoshi Fukumoto
Summary: Dental pulp stem cells, derived from multipotent neural crest cells, have high proliferative capacity and multipotent potential for various applications. Stem cells donated by patients with genetic disorders can serve as disease models. Ethical considerations and potential applications of these stem cells donated and reused are worth exploring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Maria Eugenia Cabana-Munoz, Maria Jesus Pelaz Fernandez, Jose Maria Parmigiani-Cabana, Jose Maria Parmigiani-Izquierdo, Jose Joaquin Merino
Summary: Adult mesenchymal stem cells obtained from dental structures have the potential for complete regeneration and repair in various tissues, making them valuable for regenerative dentistry and medicine. Tissue engineering plays a crucial role in sustaining and enhancing the efficacy of these stem cells. Clinical trials are needed to ensure safety and improve the treatment outcomes for different pathologies. From a bioethical and anthropological perspective, the unique nature of the human individual facilitates personalized therapy, particularly for dental and chronic systemic diseases.
Review
Biochemistry & Molecular Biology
Katarzyna Czerwiec, Malgorzata Zawrzykraj, Milena Deptula, Aneta Skoniecka, Agata Tyminska, Jacek Zielinski, Adam Kosinski, Michal Pikula
Summary: Adipose-derived mesenchymal stromal cells (AD-MSCs) have gained significant attention due to their easy availability from fat tissue and their regenerative and immunomodulatory properties. These cells show great potential in stem cell-based therapies for wound healing, orthopedic, cardiovascular, and autoimmune diseases. Numerous clinical trials have provided evidence for the effectiveness of AD-MSCs. This article presents current knowledge on AD-MSCs, their applications in pre-clinical models and clinical studies, and highlights the potential for chemically or genetically modified AD-MSCs as the next generation of stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Zizhao Mai, Huan Chen, Yu Ye, Ziyu Hu, Wenjuan Sun, Li Cui, Xinyuan Zhao
Summary: Mesenchymal stem cells exert biological functions through secreting exosomes, which play important roles in regenerative medicine and possess various advantages. Exosomes derived from dental stem cells actively participate in multiple biological processes and demonstrate promising clinical application potential.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Baoyu Li, Xuehong Xian, Xinwei Lin, Luo Huang, Ailin Liang, Hongwei Jiang, Qimei Gong
Summary: Hypoxia enhances the angiogenic potential of dental pulp stem cell exosomes (Exos) and partially alters their proteome profile. Lysyl oxidase-like 2 (LOXL2) is likely involved in hypoxia-preconditioned DPSC-Exos mediated angiogenesis.
Article
Biochemistry & Molecular Biology
Martyna Smeda, Kerstin M. Galler, Melanie Woelflick, Andreas Rosendahl, Christoph Moehle, Beate Lenhardt, Wolfgang Buchalla, Matthias Widbiller
Summary: Both dental pulp and apical papilla are potential sources of stem cells for regenerative endodontic treatments. This study compared the molecular characteristics of dental pulp stem cells (DPSC) and stem cells from the apical papilla (SCAP). The results showed that both cell types expressed similar mesenchymal stem cell markers and had the ability to differentiate into various lineages. However, differences were observed in the profiles of secreted molecules and gene regulation. Overall, both DPSC and SCAP are suitable for dental pulp tissue engineering from a molecular biological perspective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Nunthawan Nowwarote, Stephane Petit, Francois Come Ferre, Florent Dingli, Victor Laigle, Damarys Loew, Thanaphum Osathanon, Benjamin P. J. Fournier
Summary: The study identified the matrisome of ECM proteins derived from human DPSCs and found that it can regulate mineralization, even in cells which do not respond to mineralization assaults like GF.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alexandra Roi, Ciprian Roi, Meda Lavinia Negrutiu, Laura Cristina Rusu, Mircea Rivis
Summary: Dental stem cells, such as human periapical cyst mesenchymal stem cells (hPCy-MSCs), derived from the oral cavity, possess multilineage differentiation potential, immunomodulatory activity, and repair capacity. These cells exhibit similar characteristics to mesenchymal stem cells (MSCs) and hold great significance for the development of clinical applications in dentistry.
Article
Biochemistry & Molecular Biology
Anastasia Kotova, Arseniy A. Lobov, Julia A. Dombrovskaya, Valentina Y. Sannikova, Nadezhda A. Ryumina, Polina Klausen, Alexey L. Shavarda, Anna B. Malashicheva, Natella Enukashvily
Summary: Dental stem cells, derived from neural crest stem cells, exhibit differences in functional and biological properties, including neural markers, cell morphology, proliferation rate, and osteogenic differentiation capabilities. Dental pulp stem cells and periodontal ligament stem cells show distinctions in neural markers, nuclear protein expression, proliferation rate, etc.
Article
Multidisciplinary Sciences
Yuyang Chen, Xiayi Wang, Zhuoxuan Wu, Shiyu Jia, Mian Wan
Summary: Dental-derived stem cells, such as DPSCs, SHEDs, SCAPs, DFPCs, and PDLSCs, have excellent proliferation ability and multi-directional differentiation potential. They have significant application prospects in tissue regeneration due to their abundance, biocompatibility, and effectiveness. Epigenetic regulation plays a crucial role in the biological functions of dental-derived stem cells, and their potential for pulp and periodontal regeneration is highly promising.
Article
Cell & Tissue Engineering
Zhaoxia Zhang, Tao Mi, Liming Jin, Mujie Li, Chenghao Zhanghuang, Jinkui Wang, Xiaojun Tan, Hongxu Lu, Lianju Shen, Chunlan Long, Guanghui Wei, Dawei He
Summary: This study conducted a comprehensive proteomic analysis of EMVs and exosomes derived from hUC MSCs generated by different methods. The tissue repair function of EMVs and exosomes was verified by wound healing experiments, and their potential applications in different fields were revealed based on the analysis of shared and unique proteins.
STEM CELL RESEARCH & THERAPY
(2022)
Correction
Medicine, Research & Experimental
Yunji Wang, Jie Li, Ye Qiu, Bo Hu, Jin Chen, Tiwei Fu, Pengfei Zhou, Jinlin Song
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Correction
Engineering, Biomedical
Han Li, Jie Zhou, Mengyuan Zhu, Siqi Ying, Lingjie Li, Duanjing Chen, Jie Li, Jinlin Song
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Biochemical Research Methods
Yungang He, Pingmeng Deng, Ying Yan, Luying Zhu, Hongying Chen, Ting Li, Yong Li, Jie Li
Summary: This study investigates the role of tumor extracellular matrix (ECM) in the progression of oral squamous cell carcinoma (OSCC). The findings show significant differences between tumor ECM and normal ECM, and demonstrate the influence of tumor ECM on OSCC cell proliferation, apoptosis, migration, and macrophage polarization. This study highlights the importance of tumor ECM in understanding the mechanisms of OSCC and improving treatment outcomes.
JOURNAL OF PROTEOMICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Menghong Wang, Jie Li, Yanyan Ye, Duanjing Chen, Jinlin Song
Summary: This study found that exosomes from stem cells derived from human exfoliated deciduous teeth (SHED-exo) can improve proliferation, migration, cell cycle, apoptosis, and osteogenic differentiation of human periodontal ligament cells (hPDLCs). This highlights the therapeutic value of SHED-exo in the regeneration of periodontal tissues using hPDLCs in clinical practice.
Review
Dentistry, Oral Surgery & Medicine
Gang Liu, Xiaoning Qiu, Xinzhi Tan, Rong Miao, Weidong Tian, Wei Jing
Summary: This study assessed the efficacy of topical sialogogue spray containing 1% malic acid for treating xerostomia. The results showed that this spray significantly improved dry mouth symptoms and increased saliva flow rates. However, due to the limited number of studies, more research is needed in the future to provide higher quality evidence.
Article
Computer Science, Artificial Intelligence
Lei Xu, Shanluo Zhou, Jixiang Guo, Weidong Tian, Wei Tang, Zhang Yi
Summary: Metal artifacts in oral and maxillofacial CT images can affect imaging quality and pose a threat to patients' lives. This study proposes and validates a generative adversarial network (GAN) based model, MAR-GAN, to reduce these artifacts and improve image quality. The effectiveness of MAR-GAN is demonstrated on both simulated and clinical datasets, showing superior performance and clinically acceptable results.
APPLIED INTELLIGENCE
(2022)
Article
Engineering, Environmental
Zhaoyu Xu, Xingyu Hu, Li Xie, Ruojing Qian, Suru Liu, Xinzhi Tan, Meiying Shao, Chuan He, Kui Ma, Jie Long, Weidong Tian
Summary: This study proposes a safe and efficient novel root canal irrigant system with good antibacterial and tissue dissolution activities. The system exhibited excellent antibacterial effects against common clinical bacterial strains and biofilms, as well as desirable pulp tissue-dissolving efficacy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yanli Huang, Li Liu, Qian Liu, Fangjun Huo, Xingyu Hu, Shujuan Guo, Weidong Tian
Summary: The study demonstrates that D-sEV and L-D-sEV can inhibit the pathogenicity of P. gingivalis and prevent the development of periodontitis.
Review
Multidisciplinary Sciences
Hanyue Li, Hongwei Dai, Jie Li
Summary: Mesenchymal stromal/stem cells (MSCs) have the potential to treat multiple inflammatory and immune diseases due to their easy acquisition and potent immuno-regulatory capacities. Recent studies show that MSC metabolism plays critical roles in immunomodulation, providing new insights for enhancing MSC-based therapy.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Cell Biology
Jiawei Tang, Miao Tan, Siqi Liao, Mengwei Pang, Jie Li
Summary: This review summarizes the impact and mechanism of BMP-8a in female and male reproduction, teeth formation and eruption, bone and cartilage development, tissue differentiation, disease occurrence, progression, and prognosis. BMP-8a regulates the development of the uterus and plays a crucial role in late spermatogenesis. It is highly expressed in osteogenesis and differentially expressed in chondrogenesis. Furthermore, BMP-8a has a significant impact on the occurrence, development, and prognosis of various diseases.
CONNECTIVE TISSUE RESEARCH
(2023)
Review
Food Science & Technology
Jiafei Tang, Xianglu Zhu, Anet Rezek Jambrak, Da-Wen Sun, Brijesh K. Tiwari
Summary: Compared with traditional methods, cavitation-based processing technology has attracted extensive attention for its low energy consumption and high processing efficiency. This review provides a detailed account of the cavitation mechanism, factors affecting cavitation, application in food processing, extraction of natural ingredients, and discusses safety, nutrition, and future research directions.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pingmeng Deng, Jing Huang, Qixuan Zhang, Yuejia Li, Jie Li
Summary: This study aims to investigate the role of EMILIN-1 in the osteo/odontogenic differentiation of hDPSCs. The results showed that EMILIN-1 plays a crucial role in the proliferation and osteo/odontogenic differentiation of hDPSCs. This finding provides new insights for teeth and bone tissue regeneration.
Article
Engineering, Biomedical
He Wang, Xiaowei Chang, Qian Ma, Boyang Sun, Han Li, Jinmin Zhou, Yiyao Hu, Xiaoyu Yang, Jie Li, Xin Chen, Jinlin Song
Summary: Researchers have designed a bioinspired drug-delivery system for diabetic periodontal bone regeneration. The system emulates the natural bone healing cascade by releasing drugs and recruiting stem cells to promote bone regeneration. In vitro and in vivo experiments have shown that the system is effective in restoring bone healing in diabetic patients.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Boyang Sun, Siqi Ying, Qian Ma, Han Li, Jie Li, Jinlin Song
Summary: Periodontitis is an oral chronic inflammatory disease with tissue destruction being inhibited and tissue regeneration being promoted as important means for its treatment. Metformin, with its hypoglycemic and anti-inflammatory effects, can inhibit oxidative stress and activate autophagy through the AMPK/mTOR pathway. This study explores the relationship between metformin and HMGB1 in the process of periodontitis, and its findings provide evidence for metformin as a potential drug for the treatment of periodontitis and HMGB1 as a potential target for periodontal intervention.
Article
Dentistry, Oral Surgery & Medicine
Qian Ma, Yiyao Hu, Han Li, Yunchun Kuang, Jie Li, Jinlin Song
Summary: In this study, it was found that DEL-1 promotes osteogenic differentiation of hPDLSCs in high glucose and inflammation environments, and it can rescue alveolar bone loss in ligature-induced experimental periodontitis with T2DM, providing a novel therapeutic target for periodontitis with T2DM.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
