Wnt/β-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types

2-Methoxyestradiol-Mediated Induction of Frzb Contributes to Cell Death and Autophagy in MG63 Osteosarcoma Cells

(2017) Dalibel Bravo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential

(2016) Piti Techavichit et al.   BMC CANCER

Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling

(2016) Sara R. Martins-Neves et al.   CANCER LETTERS

Notch Signaling and the Skeleton

(2016) Stefano Zanotti et al.   ENDOCRINE REVIEWS

Sclerostin expression in skeletal sarcomas

(2016) Jia Shen et al.   HUMAN PATHOLOGY

LRP5 Signaling in Osteosarcomagenesis: a Cautionary Tale of Translation from Cell Lines to Tumors

(2016) Logan Horne et al.   Translational Oncology

A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model

(2016) Seth D. Goldstein et al.   Oncotarget

Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response

(2015) S. Yang et al.   JOURNAL OF CELL SCIENCE

Inhibition of GSK3β Stimulates BMP Signaling and DecreasesSOSTExpression Which Results in Enhanced Osteoblast Differentiation

(2015) Monique A.E. Schoeman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteosarcoma Stem Cells Have Active Wnt/β-catenin and Overexpress SOX2 and KLF4

(2015) Sara R. Martins-Neves et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells

(2015) Nelson Varela et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The endocrine disruptor cadmium alters human osteoblast-like Saos-2 cells homeostasis in vitro by alteration of Wnt/β-catenin pathway and activation of caspases

(2015) V. Papa et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

(2014) L. McDonald et al.   Disease Models & Mechanisms

High-Resolution Molecular Validation of Self-Renewal and Spontaneous Differentiation in Clinical-Grade Adipose-Tissue Derived Human Mesenchymal Stem Cells

(2014) Amel Dudakovic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as Potential Predictive Biomarkers for Neo-Adjuvant Chemotherapy Response in Paediatric Osteosarcoma

(2014) Jeffrey W. Martin et al.   PLoS One

Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy

(2013) Yimin Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma

(2013) Margaretha van der Deen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TWIST interacts with β-catenin signaling on osteosarcoma cell survival against cisplatin

(2013) Jianhuang Wu et al.   MOLECULAR CARCINOGENESIS

A systems biology approach reveals common metastatic pathways in osteosarcoma

(2012) Ricardo J Flores et al.   BMC Systems Biology

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

(2012) Claudia M.J. Lucero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RUNX2 in mammary gland development and breast cancer

(2012) Nicola Ferrari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt/beta-Catenin Signaling in Glioma

(2012) Kailiang Zhang et al.   Journal of Neuroimmune Pharmacology

Wnt/β-catenin signalling in prostate cancer

(2012) Robert M. Kypta et al.   Nature Reviews Urology

Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility

(2011) Margaretha van der Deen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/β-Catenin Signaling Pathway Is a Direct Enhancer of Thyroid Transcription Factor-1 in Human Papillary Thyroid Carcinoma Cells

(2011) Marie Gilbert-Sirieix et al.   PLoS One

A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2

(2011) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

(2010) Bekim Sadikovic et al.   BMC CANCER

Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

(2010) K. C. Kurek et al.   CANCER RESEARCH

Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway

(2010) Ling Ling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

(2010) Felipe C Geyer et al.   MODERN PATHOLOGY

Identification of Wnt family inhibitors: A pituitary tumor directed whole genome approach

(2010) Marianne S. Elston et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma

(2010) E. M. Rubin et al.   MOLECULAR CANCER THERAPEUTICS

Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line

(2009) Thangarajan Rajkumar et al.   ANTI-CANCER DRUGS

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling

(2009) Bekim Sadikovic et al.   HUMAN MOLECULAR GENETICS

Gene expression profiling of alpha-radiation-induced rat osteosarcomas: Identification of dysregulated genes involved in radiation-induced tumorigenesis of bone

(2009) Kazuhiro Daino et al.   INTERNATIONAL JOURNAL OF CANCER

Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma

(2009) Yuriy Shapovalov et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells

(2009) Pay-Chin Leow et al.   INVESTIGATIONAL NEW DRUGS

Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfβ in osteosarcoma cells

(2009) Inga A. San Martin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1)

(2009) Barry P. Pereira et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

(2009) Maya Kansara et al.   JOURNAL OF CLINICAL INVESTIGATION

Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma

(2008) P. Gelebart et al.   BLOOD

Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells

(2008) J. Pratap et al.   CANCER RESEARCH

Dominant Negative LRP5 Decreases Tumorigenicity and Metastasis of Osteosarcoma in an Animal Model

(2008) Yi Guo et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Expression and Function of Cbfa-1/Runx2 in Thyroid Papillary Carcinoma Cells

(2008) Toyoshi Endo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Runx2 is expressed in human glioma cells and mediates the expression of galectin-3

(2008) Valentina Vladimirova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects

(2008) Xiaoji Luo et al.   LABORATORY INVESTIGATION

Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma

(2008) Saminathan S. Nathan et al.   MOLECULAR BIOLOGY REPORTS

Cell Cycle Regulator Gene CDC5L, a Potential Target for 6p12-p21 Amplicon in Osteosarcoma

(2008) X.-Y. Lu et al.   MOLECULAR CANCER RESEARCH

Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival

(2008) Kevin Chen et al.   PEDIATRIC BLOOD & CANCER