Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma

Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma

(2016) KOJI HARADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Disulfiram/copper-disulfiram Damages Multiple Protein Degradation and Turnover Pathways and Cytotoxicity is Enhanced by Metformin in Oesophageal Squamous Cell Carcinoma Cell Lines

(2015) Rupal Jivan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Global Burden of Cancer 2013

(2015) Christina Fitzmaurice et al.   JAMA Oncology

Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones)

(2014) Leonard Howard Damelin et al.   BMC CANCER

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

(2014) Y Feng et al.   Cell Death & Disease

Oesophageal carcinoma

(2013) Arjun Pennathur et al.   LANCET

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors

(2012) Jia-Jie Hao et al.   BMC CANCER

Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells

(2011) Masanori Nakashima et al.   CANCER LETTERS

Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

(2011) D. Iliopoulos et al.   CANCER RESEARCH

Metformin activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA damage-like response

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Nucleobase Transport by Human Equilibrative Nucleoside Transporter 1 (hENT1)

(2011) Sylvia Y. M. Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic imbalances in esophageal carcinoma cell lines involve Wnt pathway genes

(2011) Jacqueline Brown   WORLD JOURNAL OF GASTROENTEROLOGY

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques

(2010) Marilanda Ferreira Bellini et al.   GENETICS AND MOLECULAR BIOLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Phase II Study of Chemoradiotherapy With 5-Fluorouracil and Cisplatin for Stage II–III Esophageal Squamous Cell Carcinoma: JCOG Trial (JCOG 9906)

(2010) Ken Kato et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Regulation and Functional Contribution of Thymidine Kinase 1 in Repair of DNA Damage

(2010) Yen-Ling Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tumor Microenvironment and DNA Repair

(2010) Thomas J. Klein et al.   SEMINARS IN RADIATION ONCOLOGY

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

(2008) Ning Zhang et al.   MOLECULES