Protection of Dexmedetomidine Against Ischemia/Reperfusion-Induced Apoptotic Insults to Neuronal Cells Occurs Via an Intrinsic Mitochondria-Dependent Pathway

Dexmedetomidine post-treatment induces neuroprotection via activation of extracellular signal-regulated kinase in rats with subarachnoid haemorrhage

(2016) Y. Wang et al.   BRITISH JOURNAL OF ANAESTHESIA

Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration

(2016) Poh-Shiow Yeh et al.   CANCER LETTERS

Neuron-derived orphan receptor 1 transduces survival signals in neuronal cells in response to hypoxia-induced apoptotic insults

(2016) Chung-Ching Chio et al.   JOURNAL OF NEUROSURGERY

Mitochondria—Judges and Executioners of Cell Death Sentences

(2016) Patrick D. Bhola et al.   MOLECULAR CELL

Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis

(2016) Chien-Ju Lin et al.   PHYTOMEDICINE

Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis

(2016) Chien-Ju Lin et al.   Oncotarget

Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats

(2016) Xianzhang Zeng et al.   PLoS One

Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-X L gene expression and protein translocation

(2015) Gong-Jhe Wu et al.   ARCHIVES OF TOXICOLOGY

Purposeful Repurposing

(2015) Melanie J. Scott   CRITICAL CARE MEDICINE

Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting

(2015) Gillian M. Keating   DRUGS

MicroRNA-1 Participates in Nitric Oxide-Induced Apoptotic Insults to MC3T3-E1 Cells by Targeting Heat-Shock Protein-70

(2015) Yong-Eng Lee et al.   International Journal of Biological Sciences

Dexmedetomidine Attenuates Oxidative Stress Induced Lung Alveolar Epithelial Cell ApoptosisIn Vitro

(2015) Jian Cui et al.   Oxidative Medicine and Cellular Longevity

Protective effects of dexmedetomidine on intestinal ischemia-reperfusion injury

(2015) YONG SUN et al.   Experimental and Therapeutic Medicine

Roles of microRNA-1 in hypoxia-induced apoptotic insults to neuronal cells

(2014) Chia-Yu Chang et al.   ARCHIVES OF TOXICOLOGY

Efficacy and Safety of Early Dexmedetomidine During Noninvasive Ventilation for Patients With Acute Respiratory Failure

(2014) John W. Devlin et al.   CHEST

Resveratrol Attenuates High-Fat Diet-Induced Disruption of the Blood–Brain Barrier and Protects Brain Neurons from Apoptotic Insults

(2014) Huai-Chia Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury (Review)

(2014) YE CAI et al.   Molecular Medicine Reports

Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus

(2013) LAKKYONG HWANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Bax phosphorylation association with nucleus and oligomerization after neonatal Hypoxia-ischemia

(2013) Smitha Krishna Infante et al.   JOURNAL OF NEUROSCIENCE RESEARCH

α2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells

(2013) Jin Won Park et al.   NEUROSCIENCE LETTERS

MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells

(2012) Chung-Ching Chio et al.   ARCHIVES OF TOXICOLOGY

Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway

(2012) J.-W. Lin et al.   NEURO-ONCOLOGY

Understanding Secondary Injury

(2012) Richard Ben Borgens et al.   QUARTERLY REVIEW OF BIOLOGY

Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission

(2011) Thomas Landes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

(2011) Maik Hüttemann et al.   MITOCHONDRION

Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway

(2010) Chi-Yuan Chuang et al.   ARCHIVES OF TOXICOLOGY

Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis

(2010) Jen A. Tan et al.   INTENSIVE CARE MEDICINE

The effectiveness of dexmedetomidine in experimental spinal cord injury compared to methylprednisolone in rats

(2010) Sanser Gul et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-Mitochondria-Mediated caspase activation

(2008) Yih-Giun Cherng et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cytochrome c: functions beyond respiration

(2008) Yong-Ling P. Ow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arterially Perfused Neurosphere-Derived Cells Distribute Outside the Ischemic Core in a Model of Transient Focal Ischemia and Reperfusion In Vitro

(2008) Chiara Pastori et al.   PLoS One

The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage

(2008) Murat Cosar et al.   SURGICAL NEUROLOGY