Obacunone causes sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF

Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1–p38–Xanthine Oxidoreductase–Dependent Cigarette Smoke–Induced Apoptosis

(2016) Jonathan Fallica et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

(2016) Kirsty E. Russell et al.   PLoS One

High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates

(2016) Thierry Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function

(2015) Nina Dickerhof et al.   FREE RADICAL BIOLOGY AND MEDICINE

Design, Synthesis, and Protein Crystallography of Biaryltriazoles as Potent Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor

(2015) Pawel Dziedzic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genkwanin Inhibits Proinflammatory Mediators Mainly through the Regulation of miR-101/MKP-1/MAPK Pathway in LPS-Activated Macrophages

(2014) Yuan Gao et al.   PLoS One

Endothelial nitric oxide synthase activation through obacunone-dependent arginase inhibition restored impaired endothelial function in ApoE-null mice

(2014) Jeongyeon Yoon et al.   VASCULAR PHARMACOLOGY

Current developments of macrophage migration inhibitory factor (MIF) inhibitors

(2013) Lei Xu et al.   DRUG DISCOVERY TODAY

Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate

(2012) Joel D. A. Tyndall et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structural Interactions Dictate the Kinetics of Macrophage Migration Inhibitory Factor Inhibition by Different Cancer-Preventive Isothiocyanates

(2012) Gregg V. Crichlow et al.   BIOCHEMISTRY

Cardioprotection Through S -Nitros(yl)ation of Macrophage Migration Inhibitory Factor

(2012) Peter Luedike et al.   CIRCULATION

Bacterial Cell Wall Constituents Induce Hepcidin Expression in Macrophages Through MyD88 Signaling

(2012) Antonio Layoun et al.   INFLAMMATION

A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF)

(2012) Fengwei Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor

(2012) Athar Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear to Cytoplasmic Translocation of Heterogeneous Nuclear Ribonucleoprotein U Enhances TLR-Induced Proinflammatory Cytokine Production by Stabilizing mRNAs in Macrophages

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Lipid-soluble Extracts from Salvia miltiorrhiza Inhibit Production of LPS-induced Inflammatory Mediators via NF-κB Modulation in RAW 264.7 Cells and Perform Antiinflammatory Effects In Vivo

(2012) Meng Li et al.   PHYTOTHERAPY RESEARCH

Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet

(2011) Eri Ono et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis

(2011) K.N. Chidambara Murthy et al.   FOOD AND CHEMICAL TOXICOLOGY

Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?

(2011) Brígida R. Pinho et al.   PLoS One

Neuroprotective effects of constituents of the root bark of Dictamnus dasycarpus in mouse hippocampal cells

(2010) Gil-Saeng Jeong et al.   ARCHIVES OF PHARMACAL RESEARCH

Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site

(2010) Larry R. McLean et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MIF as a disease target: ISO-1 as a proof-of-concept therapeutic

(2010) Yousef Al-Abed et al.   Future Medicinal Chemistry

Limonoids from Dictamnus dasycarpus Protect Against Glutamate-induced Toxicity in Primary Cultured Rat Cortical Cells

(2010) Jeong Seon Yoon et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

(2010) Y. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis

(2009) Nilesh M. Dagia et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ribosomal Protein S19 Interacts with Macrophage Migration Inhibitory Factor and Attenuates Its Pro-inflammatory Function

(2009) Ana-Maria Filip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

poly(I:C) and LPS induce distinct IRF3 and NF-κB signaling during type-I IFN and TNF responses in human macrophages

(2008) Thornik Reimer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae)

(2007) Sung-Eun Lee et al.   PHYTOMEDICINE