Article
Pharmacology & Pharmacy
S. Liu, X-M Li, J-B Yuan, L-L Li, C. Wang, X-M Lin, X. Miao, Z-C Shi
Summary: The study revealed that miR-665 is downregulated in the serum of SCI patients and LPS-induced BV2 cells, while TREM2 is upregulated. Silenced miR-665 or overexpressed TREM2 is associated with protecting inflammatory response following SCI. Rescue experiments showed that miR-665 participates in regulating inflammatory response following SCI by targeting TREM2.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Qing An, Zipeng Zhou, Yi Xie, Yu Sun, Haixiang Zhang, Yang Cao
Summary: The study demonstrated that NEAT1 plays a key role in inflammation of spinal cord injury, and its effects were mediated through the miR-211-5p/MAPK1 axis to regulate cell apoptosis rate and viability.
Article
Clinical Neurology
Shuhui Guo, Jianmin Chen, Ye Yang, Xiaolu Li, Yun Tang, Yuchang Gui, Jianquan Chen, Jianwen Xu
Summary: This study elucidated the role of miR-106b-5p in electroacupuncture (EA) treatment of spinal cord injuries (SCIs). The results showed that EA downregulated miR-106b-5p to promote autophagy and inhibit apoptosis, thereby alleviating SCI-mediated neuronal injuries.
Article
Immunology
Yonghui Hou, Jiyao Luan, Taida Huang, Tiancheng Deng, Xing Li, Zhifeng Xiao, Jiheng Zhan, Dan Luo, Yu Hou, Liangliang Xu, Dingkun Lin
Summary: In this study, TUDCA was shown to attenuate axon degeneration induced by oxidative stress in vitro and protect primary cortical neurons. In vivo, TUDCA treatment reduced tissue injury, oxidative stress, inflammation, and apoptosis, while promoting axon regeneration and remyelination in SCI mice. The functional recovery test also indicated that TUDCA treatment significantly improved limb function recovery after SCI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Fengshou Chen, Jie Han, Xiaoqian Li, Zaili Zhang, Dan Wang
Summary: Overexpression of miR-9 improves neurological outcomes after spinal cord ischemia-reperfusion injury and may inhibit blood-spinal cord barrier disruption, neuroinflammation, and apoptosis through MAP2K3- or Notch2-mediated signaling pathways.
Article
Oncology
Taibin Qiu, Haidong Yin, Yantao Wang, Chang Zhao, Daozhang Cai
Summary: The study found that miR-153 alleviated the inflammatory response and oxidative stress induced by SCI by targeting NEUROD2, demonstrating a protective role in the progression of SCI.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Neurosciences
Hongxiang Hong, Guanhua Xu, JiaJia Chen, Jinlong Zhang, Chu Chen, Chunshuai Wu, Jiawei Jiang, Zhiming Cui
Summary: This study found that LncRNA RMRP plays a regulatory role in spinal cord injury through the regulation of the miR-766-5p/FAM83A axis, and its overexpression can alleviate the condition of SCI, increase cell viability and proliferation, and inhibit apoptosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Behavioral Sciences
Hui Zhang, Duojun Wang, Jinyu Tong, Jianguo Fang, Zaijun Lin
Summary: This study found that miR-30b-5p alleviated the inflammatory response and facilitated functional recovery of spinal cord injury (SCI) rats by targeting NEFL to inactivate the mTOR pathway.
BRAIN AND BEHAVIOR
(2022)
Article
Biotechnology & Applied Microbiology
Guang Kong, Wu Xiong, Cong Li, Chenyu Xiao, Siming Wang, Wenbo Li, Xiangjun Chen, Juan Wang, Sheng Chen, Yongjie Zhang, Jun Gu, Jin Fan, Zhengshuai Jin
Summary: This study explores the influence of Treg cells on the recovery of BSCB after spinal cord injury (SCI) and its underlying mechanism. The findings suggest that Treg cell-derived exosomes can affect BSCB integrity and motor function by regulating the expression of IRAK1. This provides novel insights for functional repair and inflammation limitation after SCI.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Immunology
Yue Guo, Peng Zhang, Haosen Zhao, Chang Xu, Sen Lin, Xifan Mei, He Tian
Summary: In this study, melatonin was found to promote the beneficial polarization of microglia from pro-inflammatory to anti-inflammation, decrease ROS activity, and restore mitochondrial metabolism. Melatonin may have therapeutic potential for neuroinflammation-related neurological disorders, such as spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Justin J. Page, Jose Rosas Almanza, Shuana Xiong, Veenu Aishwarya, Antje Kroner
Summary: Functional recovery and tissue damage after spinal cord injury (SCI) are affected by secondary damage mechanisms, such as inflammation. The inflammatory response relies on various cell types, including macrophages, which can have both protective and cytotoxic functions. In this study, FANA antisense oligonucleotides targeting MAPK-activated protein kinase 2 were used to inhibit inflammation in a mouse model of contusional SCI. The treatment resulted in improved gait and tissue preservation, demonstrating the effectiveness of this targeted approach.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Article
Immunology
Sheng-Ping Fu, Si-Yu Chen, Qi-Ming Pang, Meng Zhang, Xiang-Chong Wu, Xue Wan, Wei-Hong Wan, Jun Ao, Tao Zhang
Summary: Regulating macrophage/microglia polarization, particularly from an M1 to M2 phenotype, is crucial for the regression of inflammation and tissue repair following spinal cord injury (SCI). Understanding the role of the inflammatory response and macrophages/microglia in SCI and repair can provide insights into potential therapeutic strategies for SCI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hong-Hua Song, Tian-Cheng Song, Ting Yang, Chun-Shuai Sun, Bing-Qiang He, Hui Li, Ying-Jie Wang, Yu Li, Hao Wu, Yu-Ming Hu, Yong-Jun Wang
Summary: The study demonstrates that HMGB1 mediates the astrocyte inflammatory response through regulating the COX2/PGE2 signaling pathway.
NEURAL REGENERATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xuchen Liu, Chengqiang Wang, Qingshan Peng, Birong Peng, Lixin Zhu
Summary: Pramipexole (PPX) has a neuroprotective effect in spinal cord injury (SCI) by inhibiting nerve cell apoptosis and regulating protein expression levels, which facilitates the recovery of motor function.