Article
Biochemistry & Molecular Biology
Michele Manganelli, Ilaria Grossi, Manuela Ferracin, Paola Guerriero, Massimo Negrini, Michele Ghidini, Chiara Senti, Margherita Ratti, Claudio Pizzo, Rodolfo Passalacqua, Sarah Molfino, Gianluca Baiocchi, Nazario Portolani, Eleonora Marchina, Giuseppina De Petro, Alessandro Salvi
Summary: The study investigated the longitudinal levels of cell-free long ncRNA GAS5 and microRNAs miR-126-3p and miR-23b-3p in patients with hepatocellular carcinoma (HCC) undergoing sorafenib treatment. The results highlighted the significant downregulation of miR-23b-3p in untreated HCC patients and its diagnostic relevance.
Article
Multidisciplinary Sciences
Weiping Xia, Xiang Chen, Zewu Zhu, Hequn Chen, Bingsheng Li, Kangning Wang, Li Huang, Zhi Liu, Zhi Chen
Summary: The study found that lncRNA MALAT1 promotes the process of renal interstitial fibrosis through the miR-124-3p/ITGB1 signaling pathway, suggesting its potential as a therapeutic target for RIF.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Haozi Huang, Guowei Zhang, Zhenying Ge
Summary: The overexpression of MALAT1 in diabetic rats and HG-treated cells may exacerbate renal fibrosis and cell damage via the miR-2355-3p/IL6ST axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin Yue, Wen-ying Wu, Ma Dong, Meng Guo
Summary: MALAT1 is highly expressed in breast cancer tissues and cells, promoting proliferation, migration, invasion, and doxorubicin resistance. Through targeting miR-570-3p, MALAT1 plays a pivotal role in regulating breast cancer progression and drug resistance.
BIOMEDICAL JOURNAL
(2021)
Article
Cell Biology
Yongxian Cao, Feng Zhang, Haotian Wang, Chunhua Bi, Jinpeng Cui, Fenghai Liu, Huazheng Pan
Summary: Research has shown that MALAT1 and Nova1 are upregulated in doxorubicin-resistant HCC tissues and cells, while miR-3129-5p expression is decreased. Knockdown of MALAT1 regulates doxorubicin resistance of HCC cells by inhibiting proliferation, migration, invasion, and promoting apoptosis, with Nova1 being a target gene of miR-3129-5p that can reverse the effects of miR-3129-5p expression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Toxicology
Chao Li, Jiarui Xia, Wu Yao, Guo Yang, Yangyang Tian, Yuanmeng Qi, Changfu Hao
Summary: This study reveals that LncRNA XIST can regulate the expression of miR-101-3p and up-regulate ZEB1, thereby promoting the EMT process of alveolar epithelial cells in silicosis-related pulmonary fibrosis EMT.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Liu, Lu Zheng, Rongguiyi Zhang, Ping Hou, Jiakun Wang, Linquan Wu, Jing Li
Summary: High expression of circ-ZEB1 and PIK3CA is associated with poor prognosis in HCC. Circ-ZEB1 promotes the expression of PIK3CA by silencing miR-199a-3p, affecting HCC proliferation and apoptosis.
Article
Biotechnology & Applied Microbiology
Zhe Zhao, Jianquan Liu, Zhiqin Deng, Xiaoqiang Chen, Wencui Li
Summary: This study found that MALAT1 regulates the tenogenic differentiation of TDSCs by regulating the miR-378a-3p/MAPK1 axis, indicating that this axis may be a promising avenue for the treatment of tendinopathy.
Article
Biochemistry & Molecular Biology
Xiaoxia Li
Summary: The study revealed that the MALAT1/miR-378a-3p/PDE6G signaling axis inhibits apoptosis of RMECs under high glucose conditions, which may help delay the development of diabetic retinopathy.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Cell Biology
Jun Wei, Zhiyong Wang, Chaoyi Zhong, Huarong Ding, Xiqiao Wang, Shuliang Lu
Summary: The study reveals that MIR503HG is upregulated in hypertrophic scars (HS) and plays a critical role in HS formation and progression through the miR-143-3p/Smad3 axis. Targeting MIR503HG and enhancing miR-143-3p expression can suppress HS proliferation and invasion while promoting apoptosis in human hypertrophic scar fibroblasts.
WOUND REPAIR AND REGENERATION
(2021)
Article
Medicine, General & Internal
Yuxin Zhao, Zhaoxia Wang, Meili Gao, Xuehong Wang, Hui Feng, Yuanyuan Cui, Xia Tian
Summary: MALAT1 acts as an oncogene in retinoblastoma by serving as a competing endogenous RNA to regulate the miR-655-3p/ATAD2 axis, promoting cell proliferation and metastasis while inhibiting apoptosis.
Article
Pharmacology & Pharmacy
L. Chang, D-L Jia, C-S Cao, H. Wei, Z-Q Li
Summary: The study found that PCAT-1 is significantly upregulated in OS, indicating a poor prognosis for patients. Experimental results showed that upregulation of PCAT-1 can promote proliferation, invasion, and migration of OS cells. Additionally, the study discovered that miR-508-3p is a direct target of PCAT-1, which regulates OS development by decreasing miR-508-3p and activating its target gene ZEB1.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Oncology
Baocheng Zhu, Hengguan Cui, Weiqiang Xu
Summary: Hydrogen gas treatment significantly inhibits proliferation and migration of gastric cancer cells, while affecting the expression of related genes, showing potential therapeutic effects. In addition, the lncRNA MALAT1/miR-124-3p/EZH2 axis may serve as an important target for intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Aishan Wu, Weili Sun, Fengying Mou
Summary: This study demonstrated that lncRNA-MALAT1 targeted miR-141-3p to promote HG-induced pyroptosis in H9C2 cardiomyocytes.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Orthopedics
Rigbat Rozi, Yubo Zhou, Kai Rong, Pingbo Chen
Summary: This study aimed to investigate the role of miR-124-3p in chondrocyte pyroptosis and cartilage injury in osteoarthritis (OA). The results showed that overexpression of miR-124-3p could alleviate cartilage injury and inhibit chondrocyte pyroptosis. Further investigations revealed that miR-124-3p exerted its function by regulating the expression of factors such as MALAT1 and KLF5.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)