Review
Cell Biology
Jia Jia Chan, Hossein Tabatabaeian, Yvonne Tay
Summary: The majority of human mRNAs generate alternative 3' UTRs through various processes, including RNA editing, m6A methylation, and alternative polyadenylation (APA), with 3' UTR splicing as an emerging mechanism. Regulation of these processes at the genome and transcriptome levels contribute to 3' UTR heterogeneity. Genomic variants in 3' UTR regions and aberrant 3' UTR processing are associated with cancer and their deregulation may contribute to cancer pathogenesis. In-depth characterization of these events will enhance our understanding of their significance and aid in therapeutic development.
TRENDS IN CELL BIOLOGY
(2023)
Article
Immunology
Vera Rebmann, Esther Schwich, Rafael Tomoya Michita, Lisa Gruentkemeier, Ann-Kathrin Bittner, Hana Rohn, Peter A. Horn, Oliver Hoffmann, Rainer Kimmig, Sabine Kasimir-Bauer
Summary: This study systematically evaluated the impact of HLA-G 3'UTR polymorphisms on disease status, presence of DTC, soluble HLA-G levels, and therapy and disease outcome in non-metastatic LABC patients. The results showed that specific UTR haplotypes were associated with tumor burden, presence of DTC, and therapy and disease outcome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Youssef A. Hegazy, Sara C. Cloutier, Sagar M. Utturkar, Subhadeep Das, Elizabeth J. Tran
Summary: This study used transient-transcriptome sequencing (TT-seq) to investigate the correlation of sense/antisense pairs in a dbp2 & UDelta; strain and found over 700 sense/antisense pairs, including PHO84, to be positively correlated, challenging the prevailing model. Further experiments revealed that the 3' untranslated region (3'UTR) of PHO84 plays a repressive role in sense expression independently of antisense transcripts. Genetic screening also identified factors linked to negative regulation in the 3'UTR-dependent repression of PHO84. Additionally, the study showed that the PHO84 promoter and terminator form gene loops, which correlate with transcriptional repression, and the RNA-binding protein Tho1 enhances this looping and the 3'UTR-dependent repression.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Wei Bai, Zhi Lin, Jin Ye, Linshuang Zhou, Jingqiao Xi, Wenpin Cai
Summary: Polymorphisms in the 3'UTR of the HLA-G gene are associated with the development of URSA and may serve as predictors of pregnancy outcome.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Antonela Blazekovic, Kristina Gotovacjercic, Fran Borovecki
Summary: The study aimed to assess differences in 3'UTR variants of the SNCA gene in a cohort of PD patients and control subjects from Croatia, identifying a significantly higher occurrence of a particular variant in the PD population which has not been reported previously. Further research is needed to explore the role of these variants in PD development and their impact on disease pathology.
Article
Cell Biology
Lovejeet Kaur, Deepali Sundrani, Kinjal Dave, Karuna Randhir, Savita Mehendale, Swati Bayyana, Kumaran Kalyanaraman, Giriraj R. R. Chandak, Sadhana Joshi
Summary: This study found that DNA methylation and expression of HIF1 alpha and HIF3 alpha were altered in preeclampsia placentae and were associated with preeclampsia, placental weight, and birth outcomes. Specifically, there was significant hypermethylation at cg22891070 of HIF3 alpha in preeclampsia placentae, and marginal hypomethylation at CpG8 in the promoter region of HIF1 alpha in preterm preeclampsia. Furthermore, HIF1 alpha expression was significantly lower in preterm preeclampsia compared to controls. The study also showed a negative correlation between DNA methylation in the HIF1 alpha promoter region and its expression levels, as well as associations between several CpG sites in HIF1 alpha and placental weight and birth outcomes.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Article
Health Care Sciences & Services
Young-Joo Jeon, Sung-Hwan Cho, Eo-Jin Kim, Chang-Soo Ryu, Han-Sung Park, Jong-Woo Kim, Jeong-Yong Lee, Hui-Jeong An, Nam-Keun Kim
Summary: This study found an association between 3'-UTR variants in TS genes and colorectal cancer, suggesting they could potentially serve as biomarkers for CRC prognosis and prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Xiaoguo Zheng, Yahan Lian, Jing Zhou, Qian Zhou, Yu Zhu, Chunhua Tang, Ping Zhang, Xinzhi Zhao
Summary: Preeclampsia (PE) has significant effects on the functional organization of the placental methylome, especially in terms of partially methylated domains (PMDs) and low-methylated regions (LMRs). The RUPP rat model of PE was found to accurately reflect the epigenetic mechanisms underlying human PE, with notable changes in PMDs, indicative of perturbations in the placental methylome. The changes in DNA methylation primarily occurred in LMRs, highlighting the disruption of enhancer DNA methylation due to placental ischemia. This emphasizes the importance of studying enhancer regions in future PE research.
Review
Biochemistry & Molecular Biology
Bruna Rodrigues Gontijo, Isabella Possatti, Caroline Ferreira Fratelli, Alexandre Sampaio Rodrigues Pereira, Larissa Sousa Silva Bonasser, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Silva
Summary: This systematic review aims to investigate the role of the SLC6A3 gene variant on the modulation of pharmacotherapy in Major Depressive Disorder (MDD). The presence of the SS (9R/9R) genotype and S (9R) allele has been associated with an increased risk of developing MDD and a decreased response to antidepressant therapy. However, conflicting findings among studies indicate the need for further research to understand the role of this polymorphism in the onset of MDD.
Article
Physiology
Rinaldo Rodrigues dos Passos Junior, Raiany Alves de Freitas, Julieta Reppetti, Yollyseth Medina, Vanessa Dela Justina, Camila Werle Bach, Gisele Facholi Bomfim, Victor Vitorino Lima, Alicia E. Damiano, Fernanda R. Giachini
Summary: The study showed that elevated TNF-alpha levels negatively impact AQP3 expression and cell migration in placental tissues affected by hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Guotong Chen, Yiwei Yan, Xiaojv Qiu, Chengfeng Ye, Xingmei Jiang, Shuo Song, Yibo Zhang, Huanhuan Chang, Leqi Wang, Xuehuan He, Lingrong Tang, Qingyu Zhang, Ying Zhang
Summary: This study found that miR-93-5p reduces the malignancy of ovarian cancer by targeting the CCND2 gene, inhibiting cell proliferation and migration, and promoting cell death. The expression level of miR-93-5p is negatively correlated with ovarian cancer patients and serves as a favorable predictive factor.
Article
Physiology
Manju Kandel, Stephen Tong, Susan P. Walker, Ping Cannon, Tuong-Vi Nguyen, Teresa M. MacDonald, Natalie J. Hannan, Tu'uhevaha J. Kaitu'u-Lino, Lucy A. Bartho
Summary: Preeclampsia is a pregnancy disease associated with high mortality rates for mothers and infants. This study found reduced levels of galectin-3 protein and LGALS3 mRNA expression in the placenta of women with early-onset preeclampsia.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mingyu Hu, Ji Li, Philip N. Baker, Chao Tong
Summary: Preeclampsia is a major threat to the health of mothers and newborns worldwide, primarily due to placental metabolic abnormalities leading to placental dysfunction.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Oncology
Abbas Mohammadpour-Gharehbagh, Zahra Heidari, Moein Eskandari, Abtin Aryan, Saeedeh Salimi
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Mahnaz Sandoughi, Saeedeh Salimi, Hossein Shahraki-Ghadimi, Mohsen Saravani
BIOCHEMICAL GENETICS
(2020)
Article
Medical Laboratory Technology
Z. Heidari, M. Eskandari, A. Aryan, F. Rostamzad, S. Salimi
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Article
Medical Laboratory Technology
M. Asadi-Tarani, M. Saravani, B. Teimoori, M. Ghasemi, S. Salimi
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Article
Medical Laboratory Technology
R. Maruei-Milan, Z. Heidari, A. Aryan, M. Asadi-Tarani, S. Salimi
Summary: Certain ANRIL SNPs haplotypes are associated with papillary thyroid cancer, with AAAC haplotype showing a protective effect while CAAC and CAGT haplotypes are associated with cancer. rs1333048 and rs4977574 variants are linked to tumor size, while rs10757274 and rs1333040 variants might lead to different cancer stages.
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Nourollah Ramroodi, Azar Khorrami, Seyed Mehdi Hashemi, Mahnaz Rezaei, Hossein Shahraki-Ghadim, Saeedeh Salimi
Summary: The study found an association between RNLS rs10887800 but not rs2576178 polymorphism with IS susceptibility in the overdominant model.
Article
Obstetrics & Gynecology
Saeedeh Salimi, Saman Sargazi, Milad Heidari Nia, Fariba Mirani Sargazi, Marzieh Ghasemi
Summary: The study found an association between HOTAIR gene polymorphisms and susceptibility to recurrent spontaneous abortion (RSA) in Iranian women, with certain polymorphisms increasing the risk while others decreasing it. Specific haplotypes were also linked to an increased risk of RSA.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Genetics & Heredity
Saeedeh Salimi, Saman Sargazi, Armin Zahedi Abghari, Milad Heidari Nia, Marzieh Ghasemi, Narjes Keikha
Summary: The study reveals a strong protective effect of miR29a rs157907A/G polymorphism against RSA, unaffected by age and Body Mass Index. Bioinformatic analysis shows that miR-29a targets genes involved in cell cycles, angiogenic signaling, and apoptosis of trophoblastic cells.
Article
Biotechnology & Applied Microbiology
Zahra Heidari, Saeedeh Salimi, Mohsen Rokni, Mahnaz Rezaei, Neshat Khalafi, Mahdieh Jafari Shahroudi, Azizallah Dehghan, Mohsen Saravani
Summary: The study found significant associations between IL-1 beta rs1143634 gene SNP and HT development risk, as well as COX-2 rs2745557 gene SNP and HT development. It also showed that IL-1 beta rs1143634 SNP plays a role in GD risk, while there was no significant association with NLRP3 rs3806265 gene polymorphism in the development of HT and GD.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Saeedeh Salimi, Saman Sargazi, Behrouz Mollashahi, Milad Heidari Nia, Shekoufeh Mirinejad, Mahdi Majidpour, Marzieh Ghasemi, Sara Sargazi
Summary: This study found that three functional miR146a gene polymorphisms are associated with the susceptibility to idiopathic recurrent spontaneous miscarriage (IRSM). Among them, rs6864584 T/C decreased the risk of IRSM, while rs2961920 A/C and rs57095329 A/G increased the risk. Haplotype analysis also showed that the ACA genotype combination reduced the risk of IRSM.
Article
Medical Laboratory Technology
Shaghayegh Saljooghi, Zahra Heidari, Mohsen Saravani, Mahnaz Rezaei, Saeedeh Salimi
Summary: This study found an association between AXIN1 rs12921862 C/A and rs1805105 G/A polymorphisms and PTC susceptibility, with the rs1805105 G/A polymorphism being associated with larger tumor size.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Mohsen Maleki, Mansour Karajibani, Mohsen Sarvani, Farzaneh Montazerifar, Saeedeh Salimi, Zahra Heidari
Summary: The study found a significant association between adiponectin rs2241766 polymorphism and PTC, while there was no significant relationship between adiponectin rs266729 polymorphism and the risk of PTC.
MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shaghayegh Saljooghi, Zahra Heidari, Mohsen Saravani, Mahnaz Rezaei, Saeedeh Salimi
Summary: The study found no association between FOXO1 rs17592236 polymorphism and Papillary thyroid carcinoma (PTC). However, the variant was associated with a larger tumor size (>= 1 cm) only in the log-additive model.
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rostam Maruei-Milan, Mohsen Saravani, Zahra Heidari, Mina Asadi-Tarani, Saeedeh Salimi
Article
Genetics & Heredity
MahmoudAli Kaykhaei, Hosein Moghadam, Soroosh Dabiri, Saeedeh Salimi, Danial Jahantigh, Dor Mohammad Kordi Tamandani, Ava Rasouli, Mehrnaz Narooie-Nejad