Nintedanib reduces ventilation-augmented bleomycin-induced epithelial-mesenchymal transition and lung fibrosis through suppression of the Src pathway

Novel Mechanisms for the Antifibrotic Action of Nintedanib

(2016) Sunad Rangarajan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

(2016) Yanli Yan et al.   KIDNEY INTERNATIONAL

Medical Therapy in Idiopathic Pulmonary Fibrosis

(2016) Wim Wuyts et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

(2015) Jingang Huang et al.   ANNALS OF THE RHEUMATIC DISEASES

Dasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF Pathway

(2015) Maha Abdalla et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis

(2015) Lutz Wollin et al.   EUROPEAN RESPIRATORY JOURNAL

Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

(2015) Ruby Yun-Ju Huang et al.   Oncotarget

New Therapeutic Targets in Idiopathic Pulmonary Fibrosis. Aiming to Rein in Runaway Wound-Healing Responses

(2014) Neil Ahluwalia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanical Ventilation–associated Lung Fibrosis in Acute Respiratory Distress Syndrome

(2014) Nuria E. Cabrera-Benitez et al.   ANESTHESIOLOGY

Mechanical ventilation augments bleomycin-induced epithelial–mesenchymal transition through the Src pathway

(2014) Li-Fu Li et al.   LABORATORY INVESTIGATION

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nintedanib: A Novel Therapeutic Approach for Idiopathic Pulmonary Fibrosis

(2014) I. A. Dimitroulis   Respiratory Care

Lumican Regulates Ventilation-Induced Epithelial-Mesenchymal Transition Through Extracelluar Signal-Regulated Kinase Pathway

(2013) Li-Fu Li et al.   CHEST

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

(2013) E. L. Burnham et al.   EUROPEAN RESPIRATORY JOURNAL

Src tyrosine kinase inhibition prevents pulmonary ischemia–reperfusion-induced acute lung injury

(2012) Takeshi Oyaizu et al.   INTENSIVE CARE MEDICINE

Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study

(2012) Kazuya Ichikado et al.   BMJ Open

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis

(2011) Cecilia Marmai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanical stress induces lung fibrosis by epithelial–mesenchymal transition*

(2011) Nuria E. Cabrera-Benítez et al.   CRITICAL CARE MEDICINE

Axin Pathway Activity Regulatesin VivopY654-β-catenin Accumulation and Pulmonary Fibrosis

(2011) Arnau Ulsamer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical Stretch Induces Epithelial-Mesenchymal Transition in Alveolar Epithelia via Hyaluronan Activation of Innate Immunity

(2011) Rebecca L. Heise et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alveolar Epithelial Cells Undergo Epithelial-to-Mesenchymal Transition in Response to Endoplasmic Reticulum Stress

(2011) Harikrishna Tanjore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Activation of the Wnt/β-Catenin Signaling Pathway by Mechanical Ventilation Is Associated with Ventilator-Induced Pulmonary Fibrosis in Healthy Lungs

(2011) Jesús Villar et al.   PLoS One

Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance

(2009) C. Quesnel et al.   EUROPEAN RESPIRATORY JOURNAL

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

Effects of mechanical ventilation on the extracellular matrix

(2008) Paolo Pelosi et al.   INTENSIVE CARE MEDICINE

Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis

(2008) John Victor Peter et al.   BMJ-British Medical Journal

A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly

(2007) Priscila M. F. Siesser et al.   CELL MOTILITY AND THE CYTOSKELETON