Article
Cardiac & Cardiovascular Systems
Jenifer M. Brown, Wunan Zhou, Brittany Weber, Sanjay Divakaran, Leanne Barrett, Courtney F. Bibbo, Jon Hainer, Viviany R. Taqueti, Sharmila Dorbala, Ron Blankstein, Marcelo F. Di Carli
Summary: Insufficient myocardial perfusion to match global metabolic demand may be a risk marker for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Peripheral Vascular Disease
Vibhu Parcha, Gargya Malla, Rajat Kalra, Peng Li, Ambarish Pandey, Khurram Nasir, Garima Arora, Pankaj Arora
Summary: The study evaluated the use of coronary artery calcium (CAC) score to guide hypertension therapy in individuals without cardiovascular disease. Results showed that among those with CAC>0, there was a higher risk of incident cardiovascular events in individuals with elevated BP or low-risk stage 1 hypertension, as well as in those with high-risk stage 1 or stage 2 hypertension. The study suggests that utilizing CAC score may help personalize cardiovascular risk reduction strategies in individuals where current guidelines do not recommend treatment.
Article
Medicine, General & Internal
Lourdes Vicent, Jesus Alvarez-Garcia, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Miguel Rivera, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Francisco Fernandez-Aviles, Albert Ariza-Sole, Manuel Martinez-Selles
Summary: The aim of this study was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. A total of 583 patients with left ventricular ejection fraction <40% were included in the study, among which 266 had CAD and 137 had idiopathic dilated cardiomyopathy (DCM). The study found that one-year mortality and readmissions were similar between patients with CAD and idiopathic DCM, but patients with idiopathic DCM were more likely to receive a heart transplant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Vanessa Nader, Anthony Matta, Ryeonshi Kang, Antoine Deney, Rania Azar, Charlotte Rouzaud-Laborde, Oxana Kunduzova, Romain Itier, Pauline Fournier, Michel Galinier, Didier Carrie, Jerome Roncalli
Summary: This study evaluates the effect of revascularization strategy on all-cause mortality in patients with ischaemic heart failure. The findings show that coronary revascularization does not modify short-term survival outcomes in HF patients compared with optimal medical therapy alone.
Review
Cardiac & Cardiovascular Systems
Antonio Iaconelli, Pierpaolo Pellicori, Pasquale Dolce, Matteo Busti, Aureliano Ruggio, Nadia Aspromonte, Domenico D'Amario, Mattia Galli, Giuseppe Princi, Elisabetta Caiazzo, Asma O. M. Rezig, Pasquale Maffia, Giovanni Pecorini, Filippo Crea, John G. F. Cleland
Summary: This study conducted a systematic review and meta-analysis of relevant randomized controlled trials to investigate the effects of coronary revascularization on patients with heart failure receiving guideline-recommended pharmacological therapy. The results showed that coronary revascularization was associated with a lower risk of all-cause mortality and cardiovascular mortality compared to medical therapy alone, but had no significant effect on the composite endpoint of hospitalization for heart failure or all-cause mortality.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Juan Martinez-Milla, Alvaro Acena, Ana Pello, Marta Lopez-Castillo, Hans Paul Gaebelt, Oscar Gonzalez-Lorenzo, Nieves Tarin, Carmen Cristobal, Luis M. Blanco-Colio, Jose Luis Martin-Ventura, Ana Huelmos, Andrea Kallmeyer, Joaquin Alonso, Carlos Gutierrez-Landaluce, Lorenzo Lopez Bescos, Jesus Egido, Ignacio Mahillo-Fernandez, Oscar Lorenzo, Maria Luisa Gonzalez-Casaus, Jose Tunon
Summary: This study aims to assess the influence of NT-ProBNP on the prognostic role of MM markers in patients with stable coronary artery disease. It found that PTH and NT-ProBNP are predictors of poor outcome in patients with NT-ProBNP > 125 pg/mL, while calcidiol and non-HDL cholesterol are the independent predictors of poor outcome in the subgroup of patients with NT-ProBNP <= 125 pg/mL.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Clara Saldarriaga, Dan Atar, Amanda Stebbins, Basil S. Lewis, Imran Zainal Abidin, Robert O. Blaustein, Javed Butler, Justin A. Ezekowitz, Adrian F. Hernandez, Carolyn S. P. Lam, Christopher M. O'Connor, Burkert Pieske, Piotr Ponikowski, Lothar Roessig, Adriaan A. Voors, Kevin J. Anstrom, Paul W. Armstrong
Summary: Coronary artery disease (CAD) is associated with higher cardiovascular events and heart failure hospitalizations in patients with Heart Failure with Reduced Ejection Fraction (HFrEF) and worsening HF. However, the treatment effect of vericiguat remains effective regardless of the presence of CAD. Patients with CAD are more likely to have other comorbidities compared to those without CAD.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Gu, Zhao-fang Yin, Zuo-jun Xu, Yu-qi Fan, Chang-qian Wang, Jun-feng Zhang
Summary: This study showed that after PCI, the predominant subtype of HF is HFpEF, and higher BNP levels, lower eGFR levels, and atrial fibrillation are independent risk factors for new-onset HF. Being male and being prescribed with ACEI/ARB medications are negative predictors for new-onset HF. Additionally, long-term ACEI/ARB therapy is associated with reduced risks of developing all three subtypes of HF (HFrEF, HFmrEF, and HFpEF), compared to beta-blocker use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ming-Jui Hung, Chi-Tai Yeh, Nicholas G. Kounis, Ioanna Koniari, Patrick Hu, Ming-Yow Hung
Summary: Although heart failure can worsen over time, some cases can be reversed with appropriate treatments. Coronary artery spasm is becoming the most frequent cause of heart failure worldwide, but it is often under appreciated and misdiagnosed. It can lead to various complications such as syncope, arrhythmias, and myocardial ischemic syndromes. Prompt diagnosis and treatment are important to prevent these complications. This review focuses on the epidemiology, clinical features, pathophysiology, and management of patients with coronary artery spasm-related heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Ko Yamamoto, Yukiko Matsumura-Nakano, Hiroki Shiomi, Masahiro Natsuaki, Takeshi Morimoto, Kazushige Kadota, Tomohisa Tada, Yasuaki Takeji, Yusuke Yoshikawa, Kazuaki Imada, Takenori Domei, Kazuhisa Kaneda, Ryoji Taniguchi, Natsuhiko Ehara, Ryuzo Nawada, Kyohei Yamaji, Eri Kato, Mamoru Toyofuku, Naoki Kanemitsu, Eiji Shinoda, Satoru Suwa, Atsushi Iwakura, Toshihiro Tamura, Yoshiharu Soga, Tsukasa Inada, Mitsuo Matsuda, Tadaaki Koyama, Takeshi Aoyama, Yukihito Sato, Yutaka Furukawa, Kenji Ando, Fumio Yamazaki, Tatsuhiko Komiya, Kenji Minatoya, Yoshihisa Nakagawa, Takeshi Kimura
Summary: This study found a significant interaction between heart failure and the mortality risk of PCI relative to CABG, with higher mortality risk in patients with heart failure and neutral risk in patients without heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Joel G. Ray, Peter C. Austin, Alison L. Park, Eyal Cohen, Jiming Fang, Anna Chu
Summary: Women with a history of pre-eclampsia have a higher risk of premature coronary artery disease. The assessment of obstructive coronary artery stenosis through invasive coronary angiography has not been evaluated after pre-eclampsia.
Review
Medicine, General & Internal
Arnav Katira, Ravish Katira
Summary: Colchicine may play a key role in the prevention of cardiovascular events in patients with stable and unstable coronary artery disease, as it is associated with a reduction in the rate of myocardial infarction and other major cardiovascular outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Teng Ma, Jian Zhao, Yechao Yan, Junying Liu, Jie Zang, Yaqi Zhang, Kun Ruan, Hong Xu, Wan He
Summary: This study observed 3,766 patients with stable coronary artery disease and found that higher plasma OPG levels were associated with an increased incidence of all-cause death, cardiovascular death, and heart failure. This suggests that elevated plasma OPG levels are associated with poor prognosis in patients with stable coronary artery disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Julio Nunez, Miguel Lorenzo, Gema Minana, Patricia Palau, Jose Monmeneu, Maria P. Lopez-Lereu, Jose Gavara, Victor Marcos-Garces, Cesar Rios-Navarro, Nerea Perez, Elena de Dios, Eduardo Nunez, Juan Sanchis, Francisco J. Chorro, Antoni Bayes-Genis, Vicent Bodi
Summary: The study revealed that women with known or suspected CAD are at a higher risk of new-onset HF, and the risk of new-onset HF is higher in women compared to men with LVEF >55%. Further research is needed to understand the mechanisms behind these sex-related differences.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zainali S. Chunawala, Arman Qamar, Sameer Arora, Ambarish Pandey, Marat Fudim, Muthiah Vaduganathan, Robert J. Mentz, Deepak L. Bhatt, Melissa C. Caughey
Summary: This study investigated the impact of obstructive coronary artery disease (CAD) on patients with acute decompensated heart failure (ADHF), and compared the prognostic utility between heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). The results showed that ADHF patients with coexisting obstructive CAD had higher short-term mortality, especially when involving the left main or left anterior descending coronary artery. The association between obstructive CAD and 90-day mortality was more pronounced in HFrEF patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)