Deregulated BCL-2 family proteins impact on repair of DNA double-strand breaks and are targets to overcome radioresistance in lung cancer

Phase III Study of Surgery Versus Definitive Concurrent Chemoradiotherapy Boost in Patients With Resectable Stage IIIA(N2) and Selected IIIB Non–Small-Cell Lung Cancer After Induction Chemotherapy and Concurrent Chemoradiotherapy (ESPATUE)

(2015) Wilfried Ernst Erich Eberhardt et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification ofin vivoDNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development

(2015) Jian Sun et al.   NUCLEIC ACIDS RESEARCH

A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors

(2014) Gordana Vlahovic et al.   INVESTIGATIONAL NEW DRUGS

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

(2014) Aashish Soni et al.   NUCLEIC ACIDS RESEARCH

Biomarkers That Currently Affect Clinical Practice in Lung Cancer: EGFR, ALK, MET, ROS-1, and KRAS

(2014) Grzegorz J. Korpanty et al.   Frontiers in Oncology

New radiotherapy approaches in locally advanced non-small cell lung cancer

(2013) Marianna Christodoulou et al.   EUROPEAN JOURNAL OF CANCER

DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates

(2013) Katja Paul et al.   PLoS One

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

(2012) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

The secret life of Bcl-2: Apoptosis-independent inhibition of DNA repair by Bcl-2 family members

(2012) Corentin Laulier et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors

(2011) Leena Gandhi et al.   JOURNAL OF CLINICAL ONCOLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

(2010) Panagiota A. Sotiropoulou et al.   NATURE CELL BIOLOGY

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines

(2010) H Zhang et al.   ONCOGENE

Radiation-induced cell death mechanisms

(2010) David Eriksson et al.   TUMOR BIOLOGY

Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial

(2009) Kathy S Albain et al.   LANCET

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2

(2008) Wenqi Wu et al.   DNA REPAIR

Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group

(2008) Jean-Pierre Pignon et al.   JOURNAL OF CLINICAL ONCOLOGY

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

(2008) D Li et al.   ONCOGENE

Enhanced Use of Backup Pathways of NHEJ in G2in Chinese Hamster Mutant Cells with Defects in the Classical Pathway of NHEJ

(2008) Wenqi Wu et al.   RADIATION RESEARCH

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics