Article
Dermatology
Lei Chen, Jing Yang, De-yun Wang, Jun-mei Jiang, Bao-de Zhang, Zun-jiang Zhao, Xu-Lin Chen, Da-lun Lv
Summary: To evaluate the efficacy of one-step acellular dermis combined with autologous split thickness skin grafting in the treatment of burn or trauma wounds by a multicenter controlled study. In patients with extensive burns, it is even difficult to repair the wounds due to the shortage of autologous skin. The traditional skin grafting method has disadvantages such as large damage to the donor site, insufficient skin source, and unsatisfactory appearance, wear resistance, and elasticity of the wound tissue after skin grafting.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Yi-Zhu Wu, Chun-Hui Huang, Xin-Yu Zhang, Guo-Liang Shen
Summary: This study investigated the clinical application effects of artificial dermis scaffold and autologous split-thickness skin composite grafts combined with vacuum-assisted closure (V.A.C) in refractory wounds. The results showed that this method promotes painless wound healing, improves skin survival rate, and reduces scar hyperplasia.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Feng Shang, Yan-Hua Lu, Jian Gao, Qiang Hou
Summary: This study found that in severely burned patients, artificial dermis combined with autologous split-thickness skin grafting showed better therapeutic outcomes compared to autologous intermediate-thickness skin grafting, with reduced healing time of donor skin, decreased scar formation, improved psychological recovery, and possibly enhanced functional reconstruction.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Multidisciplinary Sciences
Bijal Patel, Bryan T. Wonski, Dan M. Saliganan, Ali Rteil, Loay S. Kabbani, Mai T. Lam
Summary: By incorporating commercially-available decellularized skin dermis ECM Alloderm into the generation of biological engineered blood vessels (BEBVs), the structure and strength of the vessels were significantly enhanced, leading to maintained mechanical and structural integrity with increased collagen content. Additionally, the presence of Alloderm reduced the likelihood of thrombogenicity, allowing for successful endothelialization of the vessels.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Sita M. Damaraju, Benjamin R. Mintz, J. Genevieve Park, Ankur Gandhi, Sunil Saini, Joseph A. Molnar
Summary: This study evaluated the feasibility of a one-stage procedure using skin substitutes combined with autologous skin cell suspension in a porcine full-thickness wound healing model. Addition of autologous skin cell suspension to DS1 or DS2 resulted in a significant increase in wound re-epithelialization, indicating that this approach may be a viable one-stage treatment in clinical practice.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Critical Care Medicine
Sergey B. Bogdanov, Irina Gilevich, Karina Melkonyan, Alexander S. Sotnichenko, Sergey N. Alekseenko, Vladimir A. Porhanov
Summary: The study evaluated the effectiveness of facial burn treatment based on full-thickness skin grafting, showing that this method can achieve positive cosmetic results in the long term and reduce the risk of scar development.
Review
Medicine, General & Internal
Michael Kohlhauser, Hanna Luze, Sebastian Philipp Nischwitz, Lars Peter Kamolz
Summary: Autologous skin grafting, developed over 3500 years ago, has become the gold standard for burn wound coverage. Many techniques established in the 19th and 20th century are still used in surgical burn care today. This paper provides an overview of the evolution of skin grafting and its current role in burn care.
MEDICINA-LITHUANIA
(2021)
Article
Cell Biology
Bronwyn L. Dearman, Steven T. Boyce, John E. Greenwood
Summary: This study compared three acellular scaffolds as templates for the fabrication of skin substitutes. It found that the hybrid scaffold showed better cell retention and reduced contraction, indicating its potential as a skin substitute. Further investigation is needed for reproducibility and scalability.
WOUND REPAIR AND REGENERATION
(2022)
Article
Engineering, Biomedical
Melissa Simard, Andrea Tremblay, Sophie Morin, Cyril Martin, Pierre Julien, Julie Fradette, Nicolas Flamand, Roxane Pouliot
Summary: Polyunsaturated fatty acids (PUFAs) play a vital role in the establishment and maintenance of the skin barrier function. This study found that supplementation with alpha-linolenic acid (ALA) and linoleic acid (LA) in the culture medium improved the barrier function of a tissue-engineered skin model. The exogenously provided fatty acids were incorporated into phospholipid and triglyceride fractions of the skin substitutes, and further modulated the levels of bioactive lipid mediators. These findings highlight the importance of optimizing the supply of PUFAs in the culture media for the establishment of an improved barrier function in vitro.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Andrea Tremblay, Melissa Simard, Sophie Morin, Roxane Pouliot
Summary: The study demonstrated that supplementation of cell culture media with Docosahexaenoic acid (DHA) can enhance the barrier function of skin substitutes, reducing testosterone permeability and improving lipid profile. It was found that DHA supplementation affects the expression of tight junction proteins, particularly increasing claudin-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Surgery
Sara Kianian, Kelley Zhao, Jasleen Kaur, Kimberly W. Lu, Sourish Rathi, Kanad Ghosh, Hunter Rogoff, Thomas R. Hays, Jason Park, Miriam Rafailovich, Marcia Simon, Duc T. Bui, Sami U. Khan, Alexander B. Dagum, Gurtej Singh
Summary: This systematic review compares outcomes between acellular tissue-engineered skin constructs (acellular TCs) and cellular tissue-engineered skin constructs (cellular TCs), and finds comparable functional and wound healing outcomes between acellular TCs co-grafted with split-thickness skin grafts. However, more level 1 evidence is needed to determine the safety and efficacy of cellular TCs.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)
Review
Surgery
Bronwyn L. Dearman, Steven T. Boyce, John E. Greenwood
Summary: Skin tissue bioengineering is an emerging field aimed at improving patient quality of life and functional outcomes for deep tissue injuries by studying alternative methods. Commercial products have yet to fully fulfill the objectives of rapid wound closure and reduced scar formation.
FRONTIERS IN SURGERY
(2021)
Article
Medicine, General & Internal
Marzia Petrocelli, Giulia Togo, Silvia Ricci, Flavia Zeneli, Sebastiano Cutrupi, Annamaria Baietti, Paola Bonavolonta, Luigi Califano, Luigi Angelo Vaira, Alfonso Scarpa, Arianna Di Stadio, Giovanni Salzano
Summary: Although scalp avulsion is rare, it poses challenges in terms of management and esthetic restoration due to involvement of neurovascular structures and scar retraction. Various algorithms and techniques are available for extensive scalp defect reconstruction, depending on the type of defect. In this study, we describe six cases of total scalp avulsion that underwent immediate combined reconstruction with split-thickness skin graft (STSG) and Integra(R) matrix.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Vladislav Rosenov Dunev
Summary: This paper presents a cost-effective and efficient approach for dressing and immobilizing the penis after treating penile paraffinoma using a split-thickness skin graft (STSG).
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Engineering, Biomedical
Emilie Attiogbe, Sebastien Larochelle, Yanis Chaib, Carine Mainzer, Adele Mauroux, Sylvie Bordes, Brigitte Closs, Caroline Gilbert, Veronique J. Moulin
Summary: This study developed a cell extraction technique to isolate resident skin cells from the same donor while preserving immune and endothelial cells, and successfully reconstructed an autologous skin model with a functional immune system and a capillary network. This model is significant for studying the role of the immune system in skin diseases and inflammatory responses, as well as investigating interactions between resident skin cells and drug development.
ACTA BIOMATERIALIA
(2023)
Article
Critical Care Medicine
Carla F. Justiniano, Rebecca A. Coffey, David C. Evans, Larry M. Jones, Christian D. Jones, J. Kevin Bailey, Sidney F. Miller, Stanislaw P. Stawicki
JOURNAL OF BURN CARE & RESEARCH
(2015)
Article
Critical Care Medicine
Petra Warner, John K. Bailey, Laura Bowers, Rachel Hermann, Laura E. James, John E. McCall
JOURNAL OF BURN CARE & RESEARCH
(2016)
Article
Critical Care Medicine
Rachel Penny, Rebecca Coffey, Larry Jones, J. Kevin Bailey
JOURNAL OF BURN CARE & RESEARCH
(2017)
Article
Dermatology
Danielle M. DeBruler, Britani N. Blackstone, Molly E. Baumann, Kevin L. McFarland, Brian C. Wulff, Traci A. Wilgus, J. Kevin Bailey, Dorothy M. Supp, Heather M. Powell
LASERS IN SURGERY AND MEDICINE
(2017)
Article
Dermatology
J. Kevin Bailey, Britani N. Blackstone, Danielle M. DeBruler, Jayne Y. Kim, Molly E. Baumann, Kevin L. McFarland, Folasade O. Imeokparia, Dorothy M. Supp, Heather M. Powell
LASERS IN SURGERY AND MEDICINE
(2018)
Article
Cell Biology
Britani N. Blackstone, Jayne Y. Kim, Kevin L. McFarland, Chandan K. Sen, Dorothy M. Supp, J. Kevin Bailey, Heather M. Powell
WOUND REPAIR AND REGENERATION
(2017)
Article
Critical Care Medicine
Danielle M. DeBruler, Britani N. Blackstone, Kevin L. McFarland, Molly E. Baumann, Dorothy M. Supp, J. Kevin Bailey, Heather M. Powell
Article
Critical Care Medicine
Richard J. Kagan, Alice N. Neely, Mary T. Rieman, Angela Hardy, Petra Warner, J. Kevin Bailey, Kevin P. Yakuboff
JOURNAL OF BURN CARE & RESEARCH
(2014)
Article
Surgery
Marty O. Visscher, J. Kevin Bailey, David B. Hom
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA
(2014)
Article
Critical Care Medicine
Saurabh Mehta, Rebecca Coffey, Larry M. Jones, Heather M. Powell, J. Kevin Bailey
Article
Critical Care Medicine
Ingrid Parry, Samuel P. Mandell, Kimberly A. Hoarle, John Kevin Bailey, Sharmila Dissanaike, David Tobin Harrington, James H. Holmes, Robert Cartotto
Summary: The American Burn Association (ABA) hosted a summit to improve the quality of burn care. Participants discussed the characteristics of quality burn care, set goals for improvement, and developed a roadmap for future endeavors. The outcome of the summit included definitions of quality care, integration of current quality programs, and goals for advancing burn care.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Critical Care Medicine
Larry M. Jones, Rebecca A. Coffey, Mona P. Natwa, J. Kevin Bailey
Article
Critical Care Medicine
Larry M. Jones, Nicholas Deluga, Puneet Bhatti, Scott R. Scrape, John K. Bailey, Rebecca A. Coffey
Article
Cardiac & Cardiovascular Systems
Alistair Kent, Prabhav Patil, Victor Davila, J. Kevin Bailey, Christian Jones, David C. Evans, Creagh T. Boulger, Eric Adkins, Jayaraj M. Balakrishnan, Sebastian Valiyaveedan, Sagar C. Galwankar, David P. Bahner, Stanislaw P. Stawicki
ANNALS OF THORACIC MEDICINE
(2015)