Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts

Analyses of bone modeling and remodeling using in vitro reconstitution system with two-photon microscopy

(2015) Atsuhiko Hikita et al.   BONE

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytesin Vitro

(2015) Jordan M. Spatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

(2015) Natalie A. Sims et al.   Frontiers in Endocrinology

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

(2014) Janet L. Crane et al.   JOURNAL OF CLINICAL INVESTIGATION

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

(2013) Kuniaki Ota et al.   BONE

The Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation

(2013) Rachelle W Johnson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

(2013) Sunao Takeshita et al.   JOURNAL OF CLINICAL INVESTIGATION

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Increasing participation of sclerostin in postnatal bone development, revealed by three-dimensional immunofluorescence morphometry

(2012) Takashi Watanabe et al.   BONE

Osteocyte control of osteoclastogenesis

(2012) Charles A. O'Brien et al.   BONE

Leukemia inhibitory factor: A paracrine mediator of bone metabolism

(2012) Natalie A. Sims et al.   GROWTH FACTORS

Sclerostin and DKK1 in postmenopausal osteoporosis treated with denosumab

(2012) Davide Gatti et al.   JOURNAL OF BONE AND MINERAL RESEARCH

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

(2012) Mohammed-Salleh M Ardawi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lower fracture risk in older men with higher sclerostin concentration: A prospective analysis from the MINOS study

(2012) Pawel Szulc et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels

(2012) Sandra Jastrzebski et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tetracyclines Convert the Osteoclastic-Differentiation Pathway of Progenitor Cells To Produce Dendritic Cell-like Cells

(2012) S. Kinugawa et al.   JOURNAL OF IMMUNOLOGY

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Bisphosphonate treatment of postmenopausal osteoporosis is associated with a dose dependent increase in serum sclerostin

(2011) Davide Gatti et al.   BONE

Sostdown-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

(2011) Gabriel L. Galea et al.   FEBS LETTERS

Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody

(2011) Yuriko Furuya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization

(2011) Ingrid J Poulton et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass

(2011) Henry G. Bone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

Immunolocalization of DMP1 and sclerostin in the epiphyseal trabecule and diaphyseal cortical bone of osteoprotegerin deficient mice

(2010) Hideo Masuki et al.   BIOMEDICAL RESEARCH-TOKYO

Effects of denosumab on bone histomorphometry: The FREEDOM and STAND studies

(2010) Ian R Reid et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

(2010) Emma C. Walker et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide expression analyses establish dendritic cells as a new osteoclast precursor able to generate bone-resorbing cells more efficiently than monocytes

(2009) A Gallois et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

(2008) Emma C Walker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Comparison of the Effect of Denosumab and Alendronate on BMD and Biochemical Markers of Bone Turnover in Postmenopausal Women With Low Bone Mass: A Randomized, Blinded, Phase 3 Trial*

(2008) Jacques P Brown et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA