Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss-of-Function Gα11 Mutation

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

(2016) Katie Leach et al.   CELL RESEARCH

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders

(2016) Valerie N. Babinsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A G-protein Subunit-α11 Loss-of-Function Mutation, Thr54Met, Causes Familial Hypocalciuric Hypercalcemia Type 2 (FHH2)

(2016) Caroline M Gorvin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis

(2016) Fadil M Hannan et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Cinacalcet for Symptomatic Hypercalcemia Caused by AP2S1 Mutations

(2016) Sarah A. Howles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype–phenotype correlations, codon bias and dominant-negative effects

(2015) Fadil M. Hannan et al.   HUMAN MOLECULAR GENETICS

Cinacalcet Treatment in an Adolescent With Concurrent 22q11.2 Deletion Syndrome and Familial Hypocalciuric Hypercalcemia Type 3 Caused byAP2S1Mutation

(2015) Sirpa Tenhola et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

MutationTaster2: mutation prediction for the deep-sequencing age

(2014) Jana Marie Schwarz et al.   NATURE METHODS

Molecular Mechanisms of Phospholipase C β3 Autoinhibition

(2014) Angeline M. Lyon et al.   STRUCTURE

Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism

(2013) Fadil M. Hannan et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

(2013) K Leach et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia

(2013) M. Andrew Nesbit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant Prolactin Receptor and Familial Hyperprolactinemia

(2013) Paul J. Newey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex

(2013) Mark R. Nance et al.   STRUCTURE

Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3

(2012) M Andrew Nesbit et al.   NATURE GENETICS

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic Scaffolding Mediated by a Phospholipase C-  and Gq Signaling Complex

(2010) G. L. Waldo et al.   SCIENCE

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY