Article
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Anna Darelid, Robert Rudang, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
Summary: This prospective cohort study aimed to evaluate the association between the bone material strength index (BMSi) and the risk of incident fracture in older women. The study found that increasing BMSi was associated with a greater risk of fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Louise McMenemy, Fearghal P. Behan, Josh Kaufmann, David Cain, Alexander N. Bennett, Christopher J. Boos, Nicola T. Fear, Paul Cullinan, Anthony M. J. Bull, Andrew T. M. Phillips, Alison H. McGregor
Summary: The study examines the association between combat-related traumatic injury (CRTI) and bone health. It finds that lower limb amputees from the Iraq and Afghanistan conflicts have a higher risk of osteopenia/osteoporosis, indicating the need for alternative osteoporosis treatment approaches. The study also reveals that CRTI leads to a systemic reduction in bone mineral density (BMD) and localized BMD reduction in lower limb amputees.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alison K. Heilbronner, Matthew F. Koff, Ryan Breighner, Han Jo Kim, Matthew Cunningham, Darren R. Lebl, Alexander Dash, Shannon Clare, Olivia Blumberg, Caroline Zaworski, Donald J. McMahon, Jeri W. Nieves, Emily M. Stein
Summary: This study aimed to identify the microstructural characteristics underlying trabecular texture features. The results showed that patients with lower HRpQCT bone density and worse microarchitecture had higher texture heterogeneity in MRI, while lower QCT bone density was associated with higher texture contrast and entropy. This suggests that MRI-based measurements of trabecular bone texture can reflect microstructural properties.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Diana Ovejero, Natalia Garcia-Giralt, Nuria Martinez-Gil, Raquel Rabionet, Susanna Balcells, Daniel Grinberg, Luis Alberto Perez-Jurado, Xavier Nogues, Inigo-Etxebarria Foronda
Summary: This study reports a previously unreported familial skeletal dysplasia characterized by high bone mass and lucent bone lesions. Through clinical and genetic investigations, five rare pathogenic variants associated with bone metabolism were identified. These findings are important for understanding the molecular mechanisms underlying skeletal development and mineral metabolism.
Article
Biochemistry & Molecular Biology
Silvia Vai, Erika Marin, Roberta Cosso, Francesco Saettini, Sonia Bonanomi, Alessandro Cattoni, Iacopo Chiodini, Luca Persani, Alberto Falchetti
Summary: Adenosine Deaminase 2 Deficiency (DADA2) syndrome is a rare genetic disorder characterized by immune system disease and skeletal abnormalities. Current information on bone health in patients with this disease is still insufficient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Han Jo Kim, Alexander Dash, Matthew Cunningham, Frank Schwab, James Dowdell, Jonathan Harrison, Caroline Zaworski, Alexandra Krez, Virginie Lafage, Sanchita Agarwal, Brandon Carlson, Donald J. McMahon, Emily M. Stein
Summary: Patients who developed complications within the first six months following spine fusion surgery tend to have lower trabecular BMD, fewer and thinner trabeculae at both the radius and tibia, and thinner tibial cortices. Pre-operative DXA measurements are not predictive of complications.
Review
Biochemistry & Molecular Biology
Despoina E. Kiousi, Antonia Z. Kouroutzidou, Konstantinos Neanidis, Dimitrios Matthaios, Aglaia Pappa, Alex Galanis
Summary: Scientific advancements have increased human lifespan, but the health span of the aging population has not improved accordingly. Aging is a major risk factor for multimorbidity, resulting from loss of homeostasis, immunological and stem cell exhaustion, and heightened inflammation responses. Age-related diseases include neurodegenerative, musculoskeletal, cardiovascular, metabolic diseases and cancer. Targeting the shared biological basis of these diseases using probiotics may offer a viable alternative to manage age-related diseases. Safety and efficacy concerns, as well as the limitations of current clinical studies, are discussed in this article.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
William D. Leslie, Heenam Goel, Neil Binkley, Eugene McCloskey, Didier Hans
Summary: Lumbar spine trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture, but its sensitivity to technical factors and oral antiresorptive therapies is limited. This study analyzed TBS changes over time and in response to osteoporosis treatment, and found that TBS is strongly affected by technical factors and has little effect on monitoring response to antiresorptive treatment. Therefore, the current version of the TBS algorithm has limited usefulness in untreated individuals or routine clinical practice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alexander S. Dash, Emma Billings, Katelyn Vlastaris, Han Jo Kim, Matthew E. Cunningham, Joseph Raphael, Francis Lovecchio, John A. Carrino, Darren Lebl, Donald Mcmahon, Emily M. Stein
Summary: This study investigated pre-operative bone quality in postmenopausal women undergoing spine fusion and found that those with small bones, thinner cortices and surgeries involving more vertebral levels were at highest risk for complications.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Wu Gang, Hu Hao, Huang Yong, Feng Ruibing, Li Chaowen, Huang Yizheng, Li Chao, Zhang Haitao
Summary: This review emphasizes the therapeutic potential of Triptolide, a compound extracted from the Chinese medicinal herb Tripterygium wilfordii Hook F, in treating bone-related disorders, including inflammatory and cancerous bone tumors. The extracts of Tripterygium wilfordii Hook F have been used for centuries as anti-inflammatory, antiproliferative, antioxidative, and immunosuppressive agents, and continuous research and modifications have been made to enhance their utility in various diseases and pathophysiology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Haifeng Chen, Ruikun Zhang, Kun Yan, Wenyi Wang, Zhineng Chen, Xinmiao Yao
Summary: Osteoporosis has become a global public concern due to the aging population. However, previous research findings on osteoporosis are inconsistent, and the most appropriate exercise modality for people with osteoporosis is unclear. This study aims to investigate the best exercise type through systematic evaluation and network meta-analysis.
Article
Multidisciplinary Sciences
Marco Cossio-Bolanos, Ruben Vidal-Espinoza, Jose Fuentes-Lopez, Luis Felipe Castelli Correia de Campos, Cynthia Lee Andruske, Camilo Urra-Albornoz, Fernando Alvear Vasquez, Rossana Gomez-Campos
Summary: This study compared bone mineral density and content between Chilean and American populations, and proposed reference values for bone health measurements from ages 5 to 80. The results showed differences in bone density and mineral content between Chilean males and American males, while Chilean females had similar bone density to the US references. The study also identified the age at which maximum bone mass occurs in both males and females.
Article
Endocrinology & Metabolism
Miso Jang, Mingyu Kim, Sung Jin Bae, Seung Hun Lee, Jung-Min Koh, Namkug Kim
Summary: This study utilized a deep learning model to achieve osteoporosis screening on chest radiographs, showing promising results. The OsPor-screen model achieved an AUC of 0.91 and 0.88 in the internal and external test sets, respectively.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ruizhi Jiajue, Xiaolin Ni, Chenxi Jin, Li Huo, Huanwen Wu, Yong Liu, Jin Jin, Wei Yu, Wei Lv, Lian Zhou, Yu Xia, Yue Chi, Lijia Cui, Qianqian Pang, Xiang Li, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Xunwu Meng, Weibo Xia
Summary: Distinguishing tumor-induced rickets/osteomalacia (TIR/O) from hereditary hypophosphatemic rickets/osteomalacia (HR/O) in children and adolescents is a medical challenge. The study found significant differences in disease onset age, height standard deviation score, bone mineral density Z-score, serum FGF23 level, serum phosphate level, and serum alkaline phosphatase level between TIR/O and XLH patients. When diagnosing HR/O, family history, onset age, dental problems, and other factors are important for comprehensive evaluation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Hang Lee, Richard Eastell, Joy N. Tsai, Benjamin Z. Leder
Summary: Combination therapy of teriparatide and denosumab can significantly increase bone mineral density, while discontinuation of denosumab may lead to bone loss and increased fracture risk. A single dose of zoledronic acid effectively maintains the BMD improvements achieved with the combination therapy for at least 27 months. Spine BMD was largely preserved during this period as well.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Hematology
Ana Muntanola, Pablo Mozas, Santiago Mercadal, Maria Huguet, Sabela Bobillo, Mariana Bastos-Oreiro, Ana Jimenez-Ubieto, Jordina Rovira, Andrea Rivero, Carles Tolosa, Luis Luizaga, Sonia Gonzalez de Villambrosia, Silvana Novelli, Dolores Caballero, Antonio Salar, Sara Alonso-Alvarez, Laura Magnano, Norma C. Gutierrez, Juan-Manuel Sancho, Armando Lopez-Guillermo
Summary: Although follicular lymphoma patients who relapse within 24 months after first-line treatment have a poor prognosis, some cases show notable survival after the first relapse. Prognostic factors at progression include age, LDH levels, Hb levels, disease stage, FLIPI risk score, histological transformation, and response to salvage therapy. Patients with low/intermediate FLIPI and no histological transformation at first relapse tend to have better outcomes.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Geriatrics & Gerontology
Leena Elhussein, Annika M. M. Jodicke, Ying He, Antonella Delmestri, Danielle E. Robinson, Victoria Y. Strauss, Daniel Prieto-Alhambra
Summary: This study identified three distinct groups of older people with complex health needs based on healthcare resource use or frailty. Compared to the hospitalisation cohort, the frailty and polypharmacy cohorts had more comorbidities and higher use of preventive therapies.
Article
Hematology
Sara Redondo, Irene Garcia-Cadenas, Antonio Vila, Albert Esquirol, J. M. Portos, Silvana Novelli, Silvana Saavedra, Carol Moreno, Ana Garrido, Miguel Arguello-Tomas, Guadalupe Onate, Jordi Lopez-Pardo, Ana-Carolina Caballero, Sara Miqueleiz, Javier Briones, Jorge Sierra, Gemma Sancho, Rodrigo Martino
Summary: A retrospective study compared high-dose total body irradiation (TBI) with related or unrelated allo-SCT in patients with acute leukemia or myelodysplastic syndromes. The results showed that the FluTBI-PTCy group had a higher number of GVHD-free and relapse-free patients without systemic immunosuppression, lower incidence of acute and chronic GVHD, and early improvement of nonrelapse mortality. The CyTBI group performed worse in terms of nonrelapse mortality, but overall survival and progression-free survival were similar in both groups.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Jade Soldado-Folgado, Oriol Rins-Lozano, Itziar Arrieta-Aldea, Alicia Gonzale-Mena, Esperanza Canas-Ruano, Hernando Knobel, Natalia Garcia-Giralt, Robert Guerri-Fernandez
Summary: This pilot study aimed to assess the impact of switching from TDF to TAF ART on bone density and quality. The results showed an improvement in bone quality after switching to TAF treatment, while bone density remained unchanged. Therefore, TAF may have broader benefits for bone health beyond bone density.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Infectious Diseases
Sabina Herrera, Laura Morata, Abiu Sempere, Miguel Verdejo, Ana Del Rio, Jose Antonio Martinez, Guillermo Cuervo, Marta Hernandez-Meneses, Mariana Chumbita, Cristina Pitart, Pedro Puerta, Patricia Monzo, Carles Lopera, Francesco Aiello, Scarleth Mendoza, Carolina Garcia-Vidal, Alex Soriano, Marta Bodro
Summary: This study aimed to investigate the antimicrobial resistance of Pseudomonas aeruginosa (P. aeruginosa) in solid organ transplant (SOT) recipients. The results showed that hematologic malignancy and previous carbapenem therapy were associated with an increase in carbapenem-resistant P. aeruginosa bloodstream infections (BSIs). Age, urinary catheter, severity of infection, high-risk source, and bacteremia caused by carbapenem-resistant strains were associated with increased mortality. Correct empirical therapy was found to be a protective factor. The resistance of P. aeruginosa to carbapenems showed an increasing trend, with over 30% of isolates being resistant in the last period. SOT was not associated with a higher risk of carbapenem-resistant BSIs or higher mortality.
Article
Geriatrics & Gerontology
Annika M. Jodicke, Eng Hooi Tan, Danielle E. Robinson, Antonella Delmestri, Daniel Prieto-Alhambra
Summary: This study assessed the risk of adverse events associated with the use of antihypertensive medications in older patients with complex health needs. The results showed an increased risk of acute kidney injury and a transiently elevated risk of falls in the 30 days after starting antihypertensive therapy.
Article
Public, Environmental & Occupational Health
Marti Catala, Edward Burn, Trishna Rathod-Mistry, Junqing Xie, Antonella Delmestri, Daniel Prieto-Alhambra, Annika M. Jodicke
Summary: This study compared the performance of three methods (overlap weighting, inverse probability treatment weighting, and propensity score matching) in controlling confounding factors and conducted a target trial emulation to assess their ability to replicate COVID-19 vaccine trials.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Immunology
Javier Meseguer-Donlo, Jade Soldado-Folgado, Juan Du, Alicia Gonzalez-Mena, Fabiola Blasco-Hernando, Esperanza Canas-Ruano, Xavier Nogues, Hernando Knobel, Natalia Garcia-Giralt, Robert Guerri-Fernandez
Summary: HIV infection leads to chronic inflammation and accelerated aging. This study found that circulating miRNAs in treatment-naive HIV-infected individuals were altered, and these alterations persisted after one year of treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Geriatrics & Gerontology
Mate Szilcz, Jonas W. Wastesson, Amaia Calderon-Larranaga, Daniel Prieto-Alhambra, Pierre-Olivier Blotiere, Geric Maura, Kristina Johnell
Summary: This study investigates the association between the use of NSAIDs and ChEIs and the risk of peptic ulcers in adults aged 65 years and older. The results show that the risk of peptic ulcers is significantly higher when using both ChEIs and NSAIDs compared to NSAIDs alone.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Oncology
Miguel Arguello-Tomas, Nil Albiol, Paola Jara, Irene Garcia-Cadenas, Sara Redondo, Albert Esquirol, Silvana Novelli, Silvana Saavedra, Rodrigo Martino, Josep Nomdedeu, Jordi Sierra, Alba Mora, Carol Moreno
Summary: The treatment of CLL has greatly improved with the introduction of targeted therapies. This study aims to retrospectively describe the evolution of frontline prescription in CLL patients and evaluate its impact on TTNT and OS. After a median follow-up of 6.4 years, 41.4% of CLL patients required therapy. Alkylating agents were commonly used until 2012, followed by chemoimmunotherapy. Since 2018, targeted therapies have become the most common strategy, associated with longer TTNT and better OS.
LEUKEMIA & LYMPHOMA
(2023)
Article
Hematology
Isabel Regalado-Artamendi, Marta Garcia-Fasanella, Laura Medina, Jesus Fernandez-Sojo, Albert Esquirol, Irene Garcia-Cadenas, Rodrigo Martino, Javier Briones, Jorge Sierra, Silvana Novelli
Summary: This study describes transfusion support in lymphoma patients undergoing autologous stem cell transplant (ASCT) and identifies predictors of increased or prolonged transfusion requirement. Factors such as age over 60, pre-transplant anemia, pre-transplant thrombocytopenia, and CD34(+) cell dose <4x10(6)/kg are associated with increased transfusion requirements. These factors categorize patients into three groups with significant differences in time until transfusion independence.
Article
Medicine, General & Internal
Tomas Urdiales, Francesco Dernie, Marti Catala, Albert Prats-Uribe, Clara Prats, Daniel Prieto-Alhambra
Summary: In England, there are inequalities in testing, vaccination, and COVID-19 outcomes according to ethnicity. Compared with whites, Asian participants have an increased risk of infection and admission, while black participants have almost double the hospitalization risk and a lower vaccine uptake. Chinese participants, on the other hand, have a lower risk of testing positive, testing negative, and receiving vaccination.
Review
Hematology
Irene Garcia-Cadenas, Sara Redondo, Albert Esquirol, J. M. Portos, Silvana Novelli, Silvana Saavedra, Carol Moreno, Ana Garrido, Guadalupe Onate, Jordi Lopez, Ana-Carolina Caballero, Sara Miqueleiz, Miguel Arguello-Tomas, Javier Briones, Jorge Sierra, Rodrigo Martino
Summary: This article introduces a new allo-HCT protocol for MF patients, in which reduced doses of post-transplantation cyclophosphamide and tacrolimus are used as GVHD prophylaxis. The results show that this protocol can reduce the incidence of GVHD and achieve good engraftment and survival rates.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Rheumatology
Marta Pineda-Moncusi, Francesco Dernie, Andrea Dell'Isola, Anne Kamps, Jos Runhaar, Subhashisa Swain, Weiya Zhang, Martin Englund, Irene Pitsillidou, Victoria Y. Strauss, Danielle E. Robinson, Daniel Prieto-Alhambra, Sara Khalid
Summary: This study found that patients with a new diagnosis of OA can be divided into four clusters based on their comorbidity profile: low-morbidity, back/neck pain plus mental health, metabolic syndrome, and multimorbidity. The 'multimorbidity' cluster had the highest risk of 10-year mortality, followed by the 'metabolic syndrome' cluster and the 'back/neck pain plus mental health' cluster.
Article
Endocrinology & Metabolism
Pamela Rufus-Membere, Kara L. Holloway-Kew, Adolfo Diez-Perez, Natasha M. Appelman-Dijkstra, Mary L. Bouxsein, Erik F. Eriksen, Joshua N. Farr, Sundeep Khosla, Mark A. Kotowicz, Xavier Nogues, Mishaela Rubin, Julie A. Pasco
Summary: Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from multiple countries. BMSi values ranged from 48 to 101, with mean values of 84.4 +/- 6.9 for men and 79.0 +/- 9.1 for women.
CALCIFIED TISSUE INTERNATIONAL
(2023)