Journal
JOURNAL OF BIOSCIENCES
Volume 42, Issue 4, Pages 695-707Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-017-9710-9
Keywords
Anti-tumour immunity; cancer cell metabolism; epithelial-mesenchymal transition; tumour-initiating cells; tumour micro-environment
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Funding
- Department of Biotechnology, India [BT/HRD/NBA/34/01/2012-13, BT/PR8609/MED/12/626/2013]
- Department of Science and Technology, India [SB/SO/HS-007/2013]
- Council for Scientific and Industrial Research (CSIR)
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beta-Catenin is essential for embryonic development and required for cell renewal/regeneration in adult life. Cellular beta-catenin exists in three different pools: membranous, cytoplasmic and nuclear. In this review, we focus on functions of the nuclear pool in relation to tumorigenesis. In the nucleus, beta-catenin functions as both activator and repressor of transcription in a context-dependent manner. It promotes cell proliferation and supports tumour growth by enhancing angiogenesis. beta-Catenin-mediated signalling regulates cancer cell metabolism and is associated with tumour-initiating cells in multiple malignancies. In addition, it functions as both pro- and anti-apoptotic factor besides acting to inhibit recruitment of inflammatory anti-tumour T-cells. Thus, beta-catenin appears to possess a multifaceted nuclear function that may significantly impact tumour initiation and progression.
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