Review
Pharmacology & Pharmacy
Carina Peres, Ana Matos, Liane I. F. Moura, Rita C. Acurcio, Barbara Carreira, Sabina Pozzi, Daniella Vaskovich-Koubi, Ron Kleiner, Ronit Satchi-Fainaro, Helena F. Florindo
Summary: Targeted immunotherapies have revolutionized cancer treatment, but tumor heterogeneity and immunosuppression mechanisms have hindered the success of cancer vaccines. Nanotechnology offers promising solutions, but the selection of appropriate preclinical models is crucial.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Rana Ajeeb, John R. Clegg
Summary: The proximity and association of cerebrospinal fluid (CSF) and the intrathecal (IT) space with deep targets in the central nervous system (CNS) parenchyma makes IT injection an attractive route for brain drug delivery. However, the effectiveness of intrathecally administered macromolecules in treating neurological diseases is still debated. Our analysis of clinical trials over the past 20 years shows an increasing interest in using IT delivery for the treatment of chronic conditions with biologics. Engineering technologies have not been extensively evaluated in these trials, but recent pre-clinical studies suggest their potential in improving CNS targeting and therapeutic outcome.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Economics
Rolf Golombek, Mads Greaker, Snorre Kverndokk, Lin Ma
Summary: In this study, we model the value chain of Carbon Capture and Storage (CCS) by examining the decisions made by actors involved in capture, transport, and storage of CO2. We find that due to network effects, the market for CCS can be in a state of excess inertia, where even if the social cost of carbon justifies investment, market actors may struggle to reach the equilibrium with high investment. To address this, the government should provide economic incentives. Additionally, we identify policy instruments, including carbon tax, that can correct market imperfections and encourage private investments to reach optimal levels.
ENVIRONMENTAL & RESOURCE ECONOMICS
(2023)
Review
Cell Biology
Stanley Ulijaszek
Summary: Addressing common obesity requires obesity models that can be effectively translated into intervention models. Are we close to achieving this?
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Analytical
Isaac J. Pence, Conor L. Evans
Summary: Raman scattering based technologies are continuously being developed to address challenges in diagnostic medicine, surgical guidance, therapeutic monitoring, and histopathology. The focus is on high-speed imaging methods that provide spatial context for translational biomedical applications.
Review
Physics, Multidisciplinary
Jun Qian, Zhe Feng, Xiaoxiao Fan, Andrey Kuzmin, Anderson S. L. Gomes, Paras N. Prasad
Summary: Biophotonics is a multidisciplinary field that integrates various disciplines for optical diagnostics, bioimaging, and light activated therapies. It plays an important role in molecular medicine and provides detailed information at the subcellular level through non-invasive and radiation-free approaches.
PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Han Ling, Chen-Hui Cao, Kai Han, Yong-Rui Lv, Xiao-Dan Ma, Jing-Hua Cao, Jie-Wei Chen, Si Li, Jin-Long Lin, Yu-Jing Fang, Zhi-Zhong Pan, Dan Xie, Feng-Wei Wang
Summary: CEP63 overexpression in colorectal cancer plays a crucial role in promoting cell proliferation and tumor growth through the regulation of RBPs/RNA axis.
Article
Multidisciplinary Sciences
Qingwen Zhao, Chao Yu, Xiaoxuan Xu, Wenfang Jin, Zhe Zhang, Haiyan Huang, Yue Gao, Dongning Pan
Summary: YBX2 protein level in brown adipose tissue is induced by thermogenic stimuli through phosphorylation modification, and plays a crucial role in regulating glycolysis and thermogenesis by stabilizing YBX2.
Article
Biochemical Research Methods
Carla Rodriguez, Irene Estevez, Emilio Gonzalez-Arnay, Juan Campos, Angel Lizana
Summary: Polarimetric data is used to build recognition models for organic tissues or early disease detection. Different polarimetric observables are proposed in literature, obtained through mathematical transformations of the Mueller matrix. In this study, 12 classification models based on different polarimetric datasets are compared, highlighting the importance of using raw Mueller matrix elements for classification models design.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Psychology, Multidisciplinary
Moises Selfa-Sastre, Manoli Pifarre, Andreea Cujba, Laia Cutillas, Enric Falguera
Summary: This paper examines cases of collaborative creativity and technology in language education. The findings reveal that digital technology can play three different roles in promoting collaborative creativity in language education.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Physics, Applied
Shuyan Zhang, Keertana Vinod Ram, Ran Zhi Tong Chua, Jodie Chuan Yue Foo, Jayakumar Perumal, U. S. Dinish, Malini Olivo
Summary: The detection of volatile organic compounds (VOCs) has become an important diagnostic approach in medicine, particularly for the detection of potential biomarkers in human breath. The recent COVID-19 pandemic has increased the demand for cost-effective and noninvasive detection methods for VOCs. Biophotonics technologies offer a promising solution as they provide sensitive detection of VOCs in a cost-effective manner, making them suitable for point-of-care devices. This review critically analyzes the recent advancements in biophotonics technologies for VOCs detection, highlighting their strengths and weaknesses, and discusses future perspectives on their translation into routine disease diagnostic platforms.
APPLIED PHYSICS REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Yin Peng, Yidan Xu, Xiaojing Zhang, Shiqi Deng, Yuan Yuan, Xiaonuan Luo, Md Tofazzal Hossain, Xiaohui Zhu, Kaining Du, Fan Hu, Yang Chen, Shanshan Chang, Xianling Feng, Xinmin Fan, Hassan Ashktorab, Duane Smoot, Stephen J. Meltzer, Gangqiang Hou, Yanjie Wei, Song Li, Ying Qin, Zhe Jin
Summary: The circRNA circAXIN1 was found to be highly expressed in gastric cancer tissues compared to normal gastric tissues, and encodes a novel protein named AXIN1-295aa. AXIN1-295aa functions as an oncogenic protein, activating the Wnt signaling pathway to promote gastric cancer tumorigenesis and progression, suggesting a potential therapeutic target.
Review
Multidisciplinary Sciences
Lara A. Ray, Steven J. Nieto, Erica N. Grodin
Summary: Alcohol and substance use disorders pose challenges in effective treatment due to their heterogeneous nature. Efforts to classify addiction subtypes and apply neuroscience frameworks have the potential to advance precision medicine in this field. The use of deep behavioral phenotyping in neuroscience-informed batteries shows promise for understanding addiction on a clinical neuroscience level.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Cell Biology
Zhou-Qin Zheng, Su-Yun Wang, Zhi-Sheng Xu, Yu-Zhi Fu, Yan-Yi Wang
Summary: The SARS-CoV-2 nucleocapsid protein impairs stress granule formation induced by viral RNA, promoting viral replication. Deficiency of PKR or G3BP1 disrupts antiviral stress granule formation and enhances SARS-CoV-2 replication.
Review
Chemistry, Multidisciplinary
Farshad Moradi Kashkooli, M. Soltani, Mohammad Souri, Cameron Meaney, Mohammad Kohandel
Summary: Nanotechnology-based research in targeted drug delivery to solid tumors has made breakthroughs in cancer treatment, but still faces challenges such as inadequate tissue penetration, ineffective tumor distribution, and safety concerns. Mathematical and computational modeling allows for controlled study of these processes and helps to understand biological phenomena and select optimal anticancer treatment strategies.
Article
Biochemical Research Methods
Nathan R. Gemmell, Aongus McCarthy, Michele M. Kim, Israel Veilleux, Timothy C. Zhu, Gerald S. Buller, Brian C. Wilson, Robert H. Hadfield
JOURNAL OF BIOPHOTONICS
(2017)
Article
Biochemical Research Methods
Mira Sibai, Carl Fisher, Israel Veilleux, Jonathan T. Elliott, Frederic Leblond, David W. Roberts, Brian C. Wilson
JOURNAL OF BIOMEDICAL OPTICS
(2017)
Article
Biochemical Research Methods
Laura Marcu, Stephen A. Boppart, Mark R. Hutchinson, Juergen Popp, Brian C. Wilson
JOURNAL OF BIOMEDICAL OPTICS
(2018)
Article
Oncology
Tatsuya Kato, Cheng S. Jin, Hideki Ujiie, Daiyoon Lee, Kosuke Fujino, Hironobu Wada, Hsin-pei Hu, Robert A. Weersink, Juan Chen, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Brian C. Wilson, Gang Zheng, Kazuhiro Yasufuku
Article
Biochemical Research Methods
Lee C. L. Chin, Elina K. Cook, Darren Yohan, Anthony Kim, Carolyn Niu, Brian C. Wilson, Stanley K. Liu
BIOMEDICAL OPTICS EXPRESS
(2017)
Article
Education & Educational Research
Jason J. B. Harlow, David M. Harrison, Michael Justason, Andrew Meyertholen, Brian Wilson
PHYSICAL REVIEW PHYSICS EDUCATION RESEARCH
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Richard Ha, Lauren C. Friedlander, Hanina Hibshoosh, Christine Hendon, Sheldon Feldman, Soojin Ahn, Hank Schmidt, Margaret K. Akens, MaryAnn Fitzmaurice, Brian C. Wilson, Victoria L. Mango
ACADEMIC RADIOLOGY
(2018)
Review
Biochemical Research Methods
Brian C. Wilson, Michael Jermyn, Frederic Leblond
JOURNAL OF BIOMEDICAL OPTICS
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian W. Pogue, Timothy C. Zhu, Vasilis Ntziachristos, Keith D. Paulsen, Brian C. Wilson, Joshua Pfefer, Robert J. Nordstrom, Maritoni Litorja, Heidrun Wabnitz, Yu Chen, Sylvain Gioux, Bruce J. Tromberg, Arjun G. Yodh
Article
Multidisciplinary Sciences
Jeeun Kang, Jin Ho Chang, Sun Mi Kim, Hak Jong Lee, Haemin Kim, Brian C. Wilson, Tai-Kyong Song
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Joannie Desroches, Michael Jermyn, Michael Pinto, Fabien Picot, Marie-Andree Tremblay, Sami Obaid, Eric Marple, Kirk Urmey, Dominique Trudel, Gilles Soulez, Marie-Christine Guiot, Brian C. Wilson, Kevin Petrecca, Frederic Leblond
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Sandhya Clement, Ayad G. Anwer, Layla Pires, Jared Campbell, Brian C. Wilson, Ewa M. Goldys
Summary: Radiodynamic therapy (RDT) is a therapy that uses high-energy X-rays instead of traditional photodynamic therapy, which can effectively treat deep-seated tumors. Studies have shown that incorporating a photosensitizer into polymer nanoparticles and targeting cell-penetrating peptides can enhance the effectiveness of RDT treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Proceedings Paper
Optics
Buhong Li, Ying Gut, Brian C. Wilson
BIOPHOTONICS AND IMMUNE RESPONSES XII
(2017)
Proceedings Paper
Biophysics
Ahmad Golaraei, Vaishnavi Raja, Margarete K. Akens, Brian C. Wilson, Virginijus Barzda
CLINICAL AND PRECLINICAL OPTICAL DIAGNOSTICS
(2017)
