Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 22, Issue 8, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.22.8.087002
Keywords
quantum dots; silicon; biosensor; Forster resonance energy transfer; self-assembled monolayer
Funding
- Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- ARC Australian Laureate Fellowship [FL150100060]
- ARC Centre of Excellence in Advanced Molecular Imaging [CE140100011]
- National Health and Medical Research Council of Australia [APP1059278]
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Herein is presented a proof-of-concept study of protease sensing that combines nontoxic silicon quantum dots (SiQDs) with Forster resonance energy transfer (FRET). The SiQDs serve as the donor and an organic dye as the acceptor. The dye is covalently attached to the SiQDs using a peptide linker. Enzymatic cleavage of the peptide leads to changes in FRET efficiency. The combination of interfacial design and optical imaging presented in this work opens opportunities for use of nontoxic SiQDs relevant to intracellular sensing and imaging. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
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