Article
Engineering, Biomedical
Qiaoyu Liu, Jingwen Xue, Xinrui Zhang, Juanjuan Chai, Lu Qin, Jian Guan, Xin Zhang, Shirui Mao
Summary: In this study, the biomimetic modification of nanoparticles with endogenous surfactants was investigated to improve biocompatibility and minimize lung damage. Different phospholipids were used to modify paclitaxel (PTX)-loaded nanoparticles, leading to mucoadhesive or mucus penetration properties. The modification affected the uptake by different cells in the lung and retention in bronchoalveolar lavage fluid, as well as PTX absorption in the lung tissue. The findings provide insights for the design of inhalable nanocarriers.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Nitika Mor, Neera Raghav
Summary: In this study, the chemical transformation of carboxymethylcellulose with curcumin in ester form resulted in the development of a target-specific sustained release delivery system for curcumin in the presence of liver esterases. The synthesis and characterizations of curcumin-carboxymethylcellulose ester (Cur-CMC ester) were reported, along with its target-specific hydrolysis for curcumin release. The stability of Cur-CMC ester was demonstrated in simulated in vitro gastric fluid (pH 1.2) and intestinal fluid (pH 6.8). Upon in vitro simulation in liver homogenate, curcumin was released from Cur-CMC ester in a consistent amount (approximately 43%) over 5 hours, with the highest release observed at pH 8.0 in the presence of liver enzymes. The findings suggest that modified CMC can serve as a delivery system for curcumin in the liver and act as a prodrug system, releasing free curcumin in the presence of liver esterases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Francisca Casanova, Carla F. Pereira, Alessandra B. Ribeiro, Eduardo M. Costa, Ricardo Freixo, Pedro M. Castro, Joao C. Fernandes, Manuela Pintado, Oscar L. Ramos
Summary: This study investigates the potential use of cellulose nanostructures as carriers for the delivery of curcumin. Surface-modified cellulose showed improved encapsulation and sustained release properties for curcumin. The modified cellulose carriers reduced cytotoxicity and could be a promising drug delivery system.
Article
Chemistry, Physical
Nitika Mor, Neera Raghav
Summary: Alginate-based hydrogels are promising for drug delivery and biomedical implants due to their structural similarity to body components. This study investigates the use of sodium alginate as a sustained release delivery system for curcumin. The synthesized Curcumin-Alginate ester showed stability in gastric and intestinal fluids during in-vitro simulation. The modified alginate ester released consistent amounts of curcumin in the presence of liver esterases, suggesting its potential as a prodrug system.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Qiaoyu Liu, Xinrui Zhang, Jingwen Xue, Juanjuan Chai, Lu Qin, Jian Guan, Xin Zhang, Shirui Mao
Summary: Micro-/nanocarriers have significant advantages in pulmonary drug delivery, but different sizes of carriers have varied drug release rates, concealing the effect of particle size on drug fate in vivo. This study aims to elucidate the influence of particle size itself on drug fate in vivo after intratracheal instillation to mice by keeping drug release rate comparable.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Amarjitsing Rajput, Riyaz Ali M. Osmani, Achyut Khire, Sanket Jaiswal, Rinti Banerjee
Summary: This study developed a levonorgestrel liposome-loaded microneedle array patch for contraception, which showed better efficacy than the drug-loaded microneedle array patch. The sustained release behavior of levonorgestrel was observed for 28 days.
Article
Chemistry, Medicinal
Michael Flanagan, Qi Gan, Saahil Sheth, Rachel Schafer, Samuel Ruesing, Linda E. Winter, Karoly Toth, Silviya P. Zustiak, Adriana M. Montano
Summary: Morquio A disease is a genetic disorder caused by GALNS deficiency, and patients are treated with enzyme replacement therapy. This study explored PEG hydrogels as a drug delivery system for sustained release of rhGALNS. The optimized hydrogel formulation achieved sustained release of active rhGALNS for up to 28 days in vitro and up to 20 days in vivo, suggesting that PEG hydrogels could be a promising method for improving patient quality of life.
Article
Pharmacology & Pharmacy
Chengzhi Gao, Lanfang Zhang, Minhao Xu, Yi Luo, Ben Wang, Meiyan Kuang, Xingyou Liu, Meng Sun, Yue Guo, Lesheng Teng, Chenhui Wang, Yan Zhang, Jing Xie
Summary: The co-delivery system of SN38 prodrug and curcumin showed promising results for the treatment of lung cancer by pulmonary delivery. The system exhibited enhanced antiproliferative effect, increased cell apoptosis induction, and improved cell cycle arrest compared to single agents in vitro.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Yu-si Chen, Xue Jiang, Yi-yang Sun, Sai-ya Zhang, Ke Li, Wen-bo Chen, Yan-qiang Liu
Summary: The study aimed to establish an optimized 1-Deoxynojirimycin (DNJ) sustained-release delivery system, which showed good hypoglycemic activity and stability, as well as improved pharmacokinetics in vivo.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Chemistry, Physical
Chang Liu, Yahui Guo, Yuliang Cheng, He Qian
Summary: This study developed different small intestinal controlled delivery systems for torularhodin and evaluated their sustained-release properties. The bilosomes system showed promising results in enhancing the stability and bioavailability of torularhodin in the small intestine.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
N. Jaya Prakash, D. Shanmugarajan, B. Kandasubramanian, P. Khot, K. Kodam
Summary: The production of biodegradable dressing capable of sustained drug release, along with the monitoring of wound conditions, represents new heights of multifunctional platforms for wound care. The reported curcumin-loaded silk fibroin has shown sustained drug release over the time of 10 days through a non-Fickian diffusion process satisfying Korsmeyer-Peppas' model along with the visual monitoring of wound healing through notable color variation with pH as a biomarker. The superhydrophobic nature (water contact angle = 163.7) of the SF, along with the lipophilicity (CA = 0 (Blood)) and hygroscopic nature prevents wetting of wound surface, whereas the excess exudates from wounds are absorbed along with sufficient water and oxygen permeability. The pH responsiveness as a result of the keto-enol tautom-erism in curcumin was utilized for wound monitoring through visual indication enabling even ordinary people to detect the state of the wound. The in-situ biodegradation studies verified using cow-dung slurry, the degradability of the material with 25.3% weight loss within 30 days following first-order kinetics (R2 = 0.994), as a result of the attack of proteolytic enzymes on the amino acid units of SF, mitigating the concerns of medical wastes. (c) 2022 Elsevier Ltd. All rights reserved.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Arjak Bhattacharjee, Yongdeok Jo, Susmita Bose
Summary: The study aims to design a localized delivery system using curcumin-loaded magnesium oxide (MgO) doped 3D printed tricalcium phosphate (TCP) bone grafts for improved early stage osseointegration, chemoprevention, and antibacterial properties. The drug delivery system showed about 22% curcumin release after 30 days and resulted in approximately 8.5 times reduction in osteosarcoma viability. In vivo experiments demonstrated new bone formation up to 2.5 times higher than the control group, and the presence of MgO and curcumin exhibited about 71% antibacterial efficacy against S. aureus-induced osteomyelitis. These 3D printed osteogenic and chemopreventive scaffolds are suitable for patient-specific low load-bearing defect sites.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Roshanak Tarrahi, Alireza Khataee, Afzal Karimi, Morteza Golizadeh, Farbod Ebadi Fard Azar
Summary: A novel cellulose derivative scaffold, CM-DEAEC, was synthesized for drug delivery systems with great potential. The scaffold showed high swelling ratio, entrapment efficiency, sustained drug release profile, and antibacterial activity, making it a promising platform for drug delivery applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Vinod S. Patil, Benjamin C. Burdette, J. Zach Hilt, Douglass S. Kalika, Thomas D. Dziubla
Summary: Oral drug delivery is the most common and well tolerated method for drug administration. However, its applicability is often limited due to low drug solubility and stability. Amorphous polymeric prodrug formulations, such as PBAE hydrogels, have shown promise in improving stability and solubility of drugs for controlled release.
Article
Materials Science, Biomaterials
Yuanyuan Peng, Siyuan Yu, Zhen Wang, Pingsheng Huang, Weiwei Wang, Jinfeng Xing
Summary: The study demonstrates that drug-loaded nanogels with curcumin exhibit significant cytotoxicity towards cancer cells, effectively inhibiting tumor growth and showing stronger suppression in tumor-bearing nude mice compared to curcumin.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Clinical Neurology
Yiyang Li, Bowen Liu, Ying Chen, Xingping Quan, Yan Han, Ying Zheng, Yonghua Zhao
Summary: EVs have shown significant beneficial effects on ischemic stroke, easily penetrating the blood-brain barrier and migrating into the brain, offering new potential for IS treatment.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Qian Cheng, Meng Xu, Chen Sun, Kuikun Yang, Zhiqing Yang, Junyan Li, Jun Zheng, Ying Zheng, Ruibing Wang
Summary: A supramolecular artificial receptor-modified macrophage (SAR-Macrophage) has been developed to enhance the recognition and capture of bacteria, resulting in an efficient antibacterial approach.
MATERIALS HORIZONS
(2022)
Article
Chemistry, Multidisciplinary
Yuan He, Chang Liu, Run Han, Yingmin Liang, Judith Choi Wo Mak, Yinghao Zhu, Haifeng Li, Ying Zheng
Summary: Pulmonary delivery is an effective strategy for treating local respiratory diseases. In this study, a lipid-coated genistein nanocrystals formulation was developed to enhance drug concentration in the lungs. The formulation exhibited reduced drug release rate, decreased intracellular uptake and transcellular transport, and impeded macrophages clearance. In vivo studies showed improved lung retention and reduced systemic absorption. This research suggests that the lipid-coated nanocrystals formulation is suitable for enhancing local pulmonary delivery.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Meng Xu, Jinsong Tao, Zhengjie Wei, Qian Cheng, Hongmei Yang, Simon Ming-Yuen Lee, Kathy Qian Luo, Wei Ge, Ruibing Wang, Ying Zheng
Summary: The clinical translation of anticancer nanomedicine is limited due to nonspecific accumulation and low targeting efficiency in tumor. A bioorthogonal targeting strategy based on supramolecular recognition between β-cyclodextrin-modified tumor cells and adamantane-modified nanomedicine was established. The host-guest interactions driven targeting process was visualized in vivo at the single-cell level for the first time, providing direct evidence of bioorthogonal homing effects.
Article
Chemistry, Multidisciplinary
Meng Xu, Haidong Zha, Run Han, Yaxin Cheng, Jiamao Chen, Ludan Yue, Ruibing Wang, Ying Zheng
Summary: In this study, pH-sensitive nanoparticles were used to deliver dihydroartemisinin (DHA) for tumor therapy in multiple ways. The nanoparticles generate lethal oxidants in the tumor microenvironment and induce cancer cell death through ferroptosis. This strategy differs from traditional approaches and exhibits efficient anticancer efficacy.
Article
Immunology
Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen
Summary: There is evidence that topical administration of TET nanoemulsion can stimulate the expansion of Tregs through the TNF-TNFR2 pathway and inhibit the development of psoriasis-like disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Yuan-Fu Ding, Jianwen Wei, Xingping Quan, Wenting Gu, Long Xi, Ying Zheng, Yonghua Zhao, Jingwei Luo, Shengke Li, Greta S. P. Mok, Ruibing Wang
Summary: In this study, a supramolecular medicine was developed to efficiently suppress the formation of RNA-PA immunocomplex by sequestering polyamines (PAs) and release anti-psoriasis drug, demonstrating an enhanced anti-psoriasis activity.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Yanqi Qiao, Yan Ma, Yue Tong, Wenting Liu, Shuo Wang, Ying Zheng, Changjun Men, Jie Yu, Jie Pan, Dong Wan, Yongmei Yin, Xiujie Zhao, Rimo Xi, Meng Meng
Summary: A new near-infrared photosensitizer has been developed for effective phototherapy against H. pylori infections and resistant strains, showing synergistic photothermal therapy/photodynamic therapy effects. RNA-seq analysis revealed the potential mechanism of efficient H. pylori phototherapy.
Article
Chemistry, Multidisciplinary
Chang Liu, Long Xi, Yihan Liu, Judith Choi Wo Mak, Shirui Mao, Zhenping Wang, Ying Zheng
Summary: This study developed an inhalable biomimetic sequential drug-releasing nanoplatform for the combinatorial treatment of acute lung injury (ALI). The nanoplatform effectively inhibited the coordinated action of neutrophils and macrophages, modulated the hyper-inflammatory condition, and promoted lung tissue repair. The dual-stage drug release behavior facilitated down-regulation of pro-inflammatory cytokines and remodeling of lung immune homeostasis.
Article
Medicine, Research & Experimental
Yaxin Cheng, Jinsong Tao, Yaqi Zhang, Long Xi, Run Han, Meng Xu, Simon Ming-Yuen Lee, Wei Ge, Yong Gan, Ying Zheng
Summary: This study systematically explored the impact of shape and shear stress on the toxicity of mesoporous silica nanoparticles (MSNs) after injection. The results showed that shear stress caused mechanical damage to the cell membrane of MSNs, while the toxicity of MSNs was also attributed to oxidative damage. The addition of fetal bovine serum alleviated the toxicity of MSNs. Moreover, both spherical and rodlike MSNs caused cardiovascular toxicity and oxidative damage in in vivo models.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Yiyang Li, Bowen Liu, Tingting Zhao, Xingping Quan, Yan Han, Yaxin Cheng, Yanling Chen, Xu Shen, Ying Zheng, Yonghua Zhao
Summary: This study compared the protective efficacy of bone marrow mesenchymal stem cells derived extracellular vesicles (BMSC-EVs) and brain endothelial cells derived extracellular vesicles (BEC-EVs) on blood-brain barrier (BBB) integrity after acute ischemic stroke (IS). The findings indicated that both types of EVs had similar protective effects on reducing cerebral infarction volume, BBB leakage, and enhancing the expression of tight junction proteins ZO-1 and Claudin-5. Furthermore, BMSC-EVs showed superior efficacy in suppressing Caveolin-1 and improving neurological function.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Run Han, Zhuyifan Ye, Yunsen Zhang, Yaxin Cheng, Ying Zheng, Defang Ouyang
Summary: Liposome formulation prediction models have been developed using machine learning approaches to predict important parameters and formulation features, providing guidance for formulation design. The study found that certain drug molecule properties are prioritized for preparing liposomes with higher encapsulation. The accuracy of the prediction models was validated through experimental results, and molecular dynamics simulations were used to investigate the molecular interactions and dynamics of drug-loaded liposomes.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Meng Xu, Haidong Zha, Jiamao Chen, Simon Ming-Yuen Lee, Qi Wang, Ruibing Wang, Ying Zheng
Summary: A novel photothermal reagent was developed for efficient tumor thermal ablation. Co-loaded with nitric oxide, this reagent anchored to cancer cells through supramolecular assembly, effectively inhibiting distant tumors and lung metastases after only one treatment, while enhancing immune responses.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Biomaterials
Zhiling Song, Shiyu Meng, Zhuang Tang, Xiaoxue Yang, Yuan He, Ying Zheng, Hui Guo, Meirong Du, Yizhun Zhu, Xiaolin Wang
Summary: In this study, poly(lactic-co-glycolic acid) (PLGA) microspheres were used as carriers to encapsulate leonurine nanocrystals (Leo-nano) for the management of hyperlipidemia. The optimized formulation (Leo-nano@MP) showed high drug loading and encapsulation efficiency and followed first-order drug release kinetics in vitro over 20 days. Subcutaneous injection of Leo-nano@MP every two weeks significantly improved lipid profiles and reduced liver and kidney injury in high-fat diet-fed rats compared to daily administration of free Leo. Leo-nano@MP exhibited good biocompatibility without abnormalities in the heart, lung, spleen, and skin tissues at injection sites.
BIOMATERIALS SCIENCE
(2023)
Review
Emergency Medicine
Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, Ying Zheng, Richard D. Ye, Chris Soon Heng Tan, Yitao Wang, Jia-Hong Lu
Summary: Inflammatory bowel disease (IBD) is a chronic, non-specific, recurrent inflammatory disease that mainly affects the gastrointestinal tract. Autophagy, a lysosome-mediated catabolic process, has been found to play a critical role in IBD by regulating macrophage function. Macrophages have been shown to be important in maintaining intestinal immune homeostasis and are involved in inflammation remission and tissue repair. This knowledge of macrophage autophagy function in IBD can potentially be used as a strategy for the treatment of IBD.
