Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 106, Issue 3, Pages 1138-1147Publisher
WILEY
DOI: 10.1002/jbm.b.33889
Keywords
siloxane-gelatin coatings; silicon; protein adsorption; osteogenesis; GPTMS
Funding
- Basque Government
- Ministerio de Economia y Competitividad, Govern of Spain [MAT2014-51918-C2-2 R]
- University of the Basque Country [UFI 11/56, IT 611-13]
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A series of sol-gel derived silicon based coatings were developed to improve the osseointegration of commercial titanium dental implants. The osseointegration starts with a positive interaction between the implant surface and surrounding tissues, which is facilitated by the adsorption of plasma proteins onto the biomaterial surface immediately after implantation. It is likely that the enhancement of protein adsorption to titanium implants leads to a better implant/tissue integration. In addition, silica based biomaterials have been shown to promote osteoblast differentiation. To improve the protein adsorption and the osteogenesis, methyltrimethoxysilane (MTMOS), tetraethoxysilane (TEOS), 3-glycidoxypropyltrimethoxysilane (GPTMS), and gelatin were selected to coat titanium surfaces. Compared with non-coated titanium, the functionalized coatings enhanced the adsorption of adhesive proteins such as fibronectin and collagen. The Si release was successfully modulated by the control of the chemical composition of the coating, showing a higher dissolution rate with the gelatin and GPTMS incorporation. While the roughness of commercial implants seemed to promote the adhesion of mesenchymal stem cells (MSC), the osteogenic differentiation was greater on surfaces with Si-coatings. In this study, an improved osteogenic surface has been achieved by using the siloxane-gelatin coatings and such coatings can be used in dental implants to promote osseointegration. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1138-1147, 2018.
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