Review
Pharmacology & Pharmacy
Cristiana S. A. Bento, Marisa C. Gaspar, Patricia Coimbra, Herminio C. de Sousa, Mara E. M. Braga
Summary: Hydrogels are widely used in biomedicine as drug delivery systems, wound dressings, contact lenses, and tissue engineering scaffolds. However, their high sensitivity to terminal sterilization poses a challenge for researchers. This paper reviews the literature on hydrogel sterilization, covering conventional methods and emerging techniques, as well as considerations for aseptic processing. It also provides a summary of hydrogel materials, network types, and biomedical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Shanghui Huang, Xiangqian Hong, Mingyi Zhao, Nanbo Liu, Huiling Liu, Jun Zhao, Longquan Shao, Wei Xue, Han Zhang, Ping Zhu, Rui Guo
Summary: Nanomaterials and hydrogels have significant application value in biomedicine. Nanocomposite hydrogel systems can overcome their respective shortcomings and have broad prospects for application.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Liling Chen, Run Meng, Rui Qing, Wenfeng Li, Ziwei Wang, Yao Hou, Jia Deng, Wei Pu, Zibin Gao, Bochu Wang, Shilei Hao
Summary: We have successfully developed robust keratin hydrogels based on mechanism study through recombinant proteins, which outperform combinations of native proteins in mechanical properties and in biomedical applications.
Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Yu Wang, Jinbo Li, Jinglin Wang, Yunru Yu, Yuanjin Zhao
Summary: This article comprehensively reviews the tailoring fabrication and biomedical applications of hyaluronic acid (HA) hydrogels. The preparation methods for different forms of HA hydrogels, such as nanogels, nanofibers, microparticles, microneedle patches, injectable hydrogels, and scaffolds, are described. The shining biomedical applications of these tailored HA hydrogels in anti-bacteria, anti-inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis treatment, diagnosis, etc. are highlighted. The potentials and prospects for further investigation and translation into clinical products are also discussed.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Pedro Lavrador, Marco R. Esteves, Vitor M. Gaspar, Joao F. Mano
Summary: Recent advances in the design of stimuli-responsive nanocomposite hydrogels have expanded their potential for operating as advanced systems in various biomedical applications, benefitting from tailored single or multi-responsiveness. The combination of hydrogels and nanoparticles showcases an intrinsic ability to react to external or internal/physiological stimuli, developing intelligent systems with application-oriented features.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Qinghe Wang, Yan Zhang, Yue Ma, Miao Wang, Guoqing Pan
Summary: Nano-crosslinked dynamic hydrogels, which combine the properties of dynamic hydrogels and nanomaterials, have been extensively studied in biomedical applications. By incorporating nanomaterials as crosslinkers, the mechanical properties of hydrogels can be improved and additional functionalities can be achieved. These hydrogels show excellent biocompatibility and can promote cell proliferation and differentiation.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Kouka Luc Delma, Anna Lechanteur, Brigitte Evrard, Rasmane Semde, Geraldine Piel
Summary: Sterilization of liposomes is a challenge due to their sensitivity, and conventional methods like heat or irradiation are not suitable. Alternative methods, such as using ScCO2 technology, may be a promising strategy for achieving sterility of liposomes, but further studies are needed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Ana P. C. Almeida, Joao N. Saraiva, Goncalo Cavaco, Raquel P. Portela, Catarina R. Leal, Rita G. Sobral, Pedro L. Almeida
Summary: Bacterial cellulose-based membranes have gained increasing attention as dressings for healing purposes. This study produced, modified, and characterized hydrated and dehydrated BC membranes for biomedical applications. The results showed that the cross-linked bacterial cellulose membranes exhibit suitable physical properties for use as wound dressings.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Polymer Science
Yaxin Xie, Qiuyue Guan, Jiusi Guo, Yilin Chen, Yijia Yin, Xianglong Han
Summary: Hydrogels, as hydrophilic polymer networks, have shown significant potential in biomedical applications. Recent studies have focused on embedding exosomes into hydrogels to maintain their biological activity and achieve controlled release.
Article
Chemistry, Applied
Mina Rajabi, Michelle McConnell, Jaydee Cabral, M. Azam Ali
Summary: Tissue engineering and regenerative medicine have progressed to a new stage due to recent advancements in biology, material sciences, and 3D printing. Chitosan-based hydrogels, widely used in biomedical applications, hold promise for future development when combined with 3D printing technology. This combination has the potential to create next generation biomedical implants.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Multidisciplinary
Hassan Rammal, Amin GhavamiNejad, Ahmet Erdem, Rene Mbeleck, Mohammad Nematollahi, Sibel Emir Diltemiz, Halima Alem, Mohammad Ali Darabi, Yavuz Nuri Ertas, Edward J. Caterson, Nureddin Ashammakhi
Summary: Hydrogels are essential biomaterials with applications in drug and cell delivery, tissue engineering, 3D printing, sensing, and actuating. The advent of self-healing hydrogels allows for smarter materials with sustainable mechanical properties under stress. The self-healing mechanisms of these materials rely on chemical bonding or physical interactions, but challenges in healing characteristics need to be addressed and investigated before clinical applications.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Pharmacology & Pharmacy
Aziz Ullah, Sung In Lim
Summary: Hydrogels are three-dimensional polymeric networks that can absorb biological fluids and are used in various biomedical applications. They are prepared using chemical or physical crosslinking mechanisms, with the building blocks playing a crucial role in determining their properties.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Jennika Karvinen, Minna Kellomaki
Summary: Self-healing hydrogels are attractive biomaterials capable of repairing their structure and properties when damaged. However, the lack of standardization in characterization methods makes it challenging to compare different hydrogels. To facilitate comparison and development, a consistent set of characterization methods and more quantitative and theoretical studies are recommended.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Polymer Science
Md Mahamudul Hasan Rumon, Anwarul Azim Akib, Fahmida Sultana, Md Moniruzzaman, Mahruba Sultana Niloy, Md Salman Shakil, Chanchal Kumar Roy
Summary: Self-healing hydrogels are promising materials in biomedical applications with controllable responses to external stimuli. The suitable combination of materials and challenges in development are crucial for their advancement.
Review
Chemistry, Medicinal
Simonida L. J. Tomic, Marija M. Babic M. Radic, Jovana S. Vukovic, Vuk V. Filipovic, Jasmina Nikodinovic-Runic, Marija Vukomanovic
Summary: This review paper discusses the multifunctional biomedical applications of alginate-based hydrogels and scaffolds, highlighting the influence of alginate on the essential properties of these applications. The first part reviews the scientific achievements of alginate in dermal tissue regeneration, drug delivery systems, cancer treatment, and antimicrobials. The second part presents the author's research on hydrogel materials for scaffolds based on alginate in synergy with different materials. The study shows that alginate plays a crucial role in achieving the desired properties of these materials.
Article
Materials Science, Ceramics
A. C. Branco, T. Santos, M. Polido, R. Colaco, A. P. Serro, C. G. Figueiredo-Pina
Summary: This study investigated the suitability of leucite-zirconia composites for dental restoration. Results showed that the composite with 25% nano-zirconia exhibited appropriate optical, mechanical, and tribological properties, and could be used to produce highly translucent dental restorations.
CERAMICS INTERNATIONAL
(2022)
Review
Chemistry, Physical
Monica Antunes, Rodrigo Lino Santos, Joao Pereira, Paulo Rocha, Ricardo Bayao Horta, Rogerio Colaco
Summary: The production of ordinary Portland cement releases large amounts of CO2, posing a challenge to global climate concerns. This paper reviews alternative clinker technologies that reduce CO2 emissions and explores the possibility of transitioning from fuel combustion to electrification.
Article
Engineering, Biomedical
Andreia S. Oliveira, Ines Ferreira, Ana C. Branco, Joao C. Silva, Carolina Costa, Pedro Nolasco, Ana C. Marques, Diana Silva, Rogerio Colaco, Celio G. Figueiredo-Pina, Ana P. Serro
Summary: Hydrogels have great potential as human cartilage replacement materials and drug delivery platforms. This study developed PCU-based hydrogels capable of releasing an anti-inflammatory drug for the first time. The addition of 15% CA and 2% CNT improved the mechanical properties of the hydrogels. The materials demonstrated controlled drug release for at least 4 days and high biocompatibility.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Chemical
Joao Cruz, Victoria Corregidor, Bruno Nunes, Luis Alves, Rogerio Colaco, Eduardo Alves
Summary: This study demonstrates the formation of a nitride layer on the surface of steel coinage dies using high fluence implantation of N-14(+) ions. The results show that nitrogen implantation at room temperature with a nominal fluence of 5.0 x 10(17) at/cm(2) significantly increases die hardness and exhibits lower crack density and similar wear resistance compared to standard coatings.
Article
Materials Science, Ceramics
N. Ribeiro, M. Reis, L. Figueiredo, A. Pimenta, L. F. Santos, A. C. Branco, A. P. Alves de Matos, M. Salema-Oom, A. Almeida, M. F. C. Pereira, R. Colaco, A. P. Serro
Summary: The study aimed to enhance the properties of commercial CPC for injectability and as a sustained antibiotic delivery system. The optimal formulation contained 42%LP + HPMC + 1.87% GS, displaying excellent properties and injectability, with sustained release of antibiotic for at least 14 days.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Ana F. Pereira-da-Mota, Maria Vivero-Lopez, Maria Serramito, Luis Diaz-Gomez, Ana Paula Serro, Gonzalo Carracedo, Fernando Huete-Toral, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: This study designed contact lenses that can sustainedly deliver cholesterol-lowering drugs to the eye, improving efficacy and minimizing systemic side effects. Bioinspired hydrogels were used to release pravastatin, and high hydrostatic pressure sterilization ensured stability. In vitro and in vivo tests demonstrated the release and accumulation of the drug in the eye, with strong correlations found between in vitro and in vivo results.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Andreia S. Oliveira, Joao C. Silva, Monica Loureiro, Ana C. Marques, Nicholas A. Kotov, Rogerio Colaco, Ana P. Serro
Summary: Poly(p-phenylene-2,6-benzobisoxazole) (PBO) nanofibers combined with polyvinyl alcohol (PVA) form a super-strong structure with high water content, high mechanical stiffness, low friction, and excellent biocompatibility, surpassing most existing hydrogels. These PVA-PBO composites have potential applications in load-bearing tissues design and other industrial fields requiring high thermal and mechanical resistance, as well as pH responsiveness functionality.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Leonor Vasconcelos Garcia, Diana Silva, Maria Madalena Costa, Henrique Armes, Madalena Salema-Oom, Benilde Saramago, Ana Paula Serro
Summary: Chronic wound treatment is a major contributor to global medical expenses. The development of novel wound care systems, such as wound dressings loaded with antiseptics, can offer a solution. This study investigated the potential of casein hydrogel dressings loaded with Octiset(R) or polyhexanide for treating chronic wounds. The hydrogels showed desirable physical properties and sustained controlled drug-release, while also exhibiting good antimicrobial properties and compatibility with biological systems.
Article
Biochemistry & Molecular Biology
Mariana T. Donato, Jonas Deuermeier, Rogerio Colaco, Luis C. Branco, Benilde Saramago
Summary: The goal of this study was to develop new protic ionic liquids (PILs) as additives for lubrication of micro and nanoelectromechanical systems (MEMS and NEMS). Ten PILs with different combinations of cations such as [MIMH], [4-picH], [PyrH], [DBUH], and [TMGH], and anions such as [HSO4] and [MeSO3] were tested as additives in polyethylene glycol (PEG200) to lubricate steel/silicon and silicon/silicon contacts. The best performing additive was found to be [4-picH][HSO4], which formed a protective film on the silicon surface, resulting in a 15-fold reduction in wear compared to PEG200 alone.
Editorial Material
Biotechnology & Applied Microbiology
Asif Ahmad Bhat, Ritu Gilhotra, Yogendra Singh, Sanjay Sharma, Terezinha de Jesus Andreoli Pinto, Humberto Gomes Ferraz, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Review
Chemistry, Physical
Ana Catarina Branco, Rogerio Colaco, Celio Gabriel Figueiredo-Pina, Ana Paula Serro
Summary: Zirconia-based materials are widely used in dentistry due to their biocompatibility and suitable mechanical and tribological behavior. 3D printing techniques, such as stereolithography (SLA) and digital light processing (DLP), have shown promising outcomes for additive manufacturing (AM) of zirconia-based materials. However, there are concerns regarding dimensional accuracy, resolution, and mechanical strength of the printed pieces. Despite these challenges, there is a remarkable commitment to adapting materials and workflows to digital technologies, making the research in this field a disruptive technological progress with numerous application possibilities.
Review
Chemistry, Physical
Monica Antunes, Rodrigo L. Santos, Ricardo B. Horta, Rogerio Colaco
Summary: Due to the environmental impact of CO2 emissions from ordinary Portland cement (OPC) production and the increasing demand for this material, finding alternative products has become a global concern. One alternative is amorphous-wollastonitic low-calcium hydraulic binders (AWLCs), which can significantly reduce CO2 emissions and can be fully electrified for production. This paper presents a state-of-the-art review of the latest research on AWLCs, including their physicochemical and mechanical characteristics, as well as possible routes for industrial-scale production.
Article
Polymer Science
Ana C. Branco, Andreia S. Oliveira, Ines Monteiro, Pedro Nolasco, Diana C. Silva, Celio G. Figueiredo-Pina, Rogerio Colaco, Ana P. Serro
Summary: New PVA-based hydrogels were developed with improved tribomechanical properties and controlled drug release of diclofenac through PAA addition, PEG immersion, and annealing treatment. These hydrogels show promising potential for cartilage replacement and local drug delivery systems by enhancing their mechanical performance while ensuring controlled drug release.
Article
Biotechnology & Applied Microbiology
Diana M. C. Marques, Joao C. Silva, Ana Paula Serro, Joaquim M. S. Cabral, Paola Sanjuan-Alberte, Frederico C. Ferreira
Summary: In this study, novel bioinks based on kappa-carrageenan were successfully formulated and used to fabricate 3D scaffolds. The ink formulation and printing parameters were optimized, enabling the manufacturing of complex structures. Mechanical tests and cell viability assays demonstrated the excellent performance of this material, indicating its potential applications in tissue engineering and cellular agriculture.
BIOENGINEERING-BASEL
(2022)