Review
Biochemistry & Molecular Biology
Joanna Pota, Katarzyna Winnicka
Summary: This article investigates the potential of polyelectrolyte multilayers (PEMs) as drug delivery materials. It discusses the effects of polymer combinations, technological parameters, and physicochemical characteristics on the multilayers. Despite their widespread use in functionalizing implantable scaffolds, the application of PEM coatings in drug administration is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Anna S. Vikulina, Jack Campbell
Summary: An undeniable trend in modern bioengineering and nanotechnology is the use of various biomolecules, primarily polymeric, for designing novel functional materials in controlled drug delivery, bioimaging, tissue engineering, and other bioapplications. Biogenic polymers with features like biocompatibility, biodegradability, replicating natural cellular microenvironments, and minimal toxicity, have gained growing interest as building blocks for fourth-generation biomaterials. Recent studies highlight the promise of hard-templating approach in fabricating nano- and microparticles using biopolymers, covering up-to-date knowledge on this topic and assessing the progress and challenges in the field.
Article
Biochemistry & Molecular Biology
Joanna Potas, Agnieszka Zofia Wilczewska, Pawel Misiak, Anna Basa, Katarzyna Winnicka
Summary: Polyelectrolyte multilayers (PEMs) based on polyelectrolyte complex (PEC) structures are interesting materials for functionalized coatings and drug delivery platforms. This study optimized the formulation of chitosan/low-methoxy amidated pectin multilayer films and investigated their thermal properties, chemical structure, mechanical properties, and internal structure. The results showed that films with confirmed multilayer architecture are promising for buccal drug delivery and have improved thermal stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jialin Fu, Jia Xin Yap, Choe Peng Leo, Chun Kiat Chang
Summary: In this study, carboxymethyl cellulose (CMC)/sodium alginate (SA) hydrogel beads were modified with calcium carbonate (CaCO3) and/or bentonite (Be) to improve phosphate adsorption. Incorporation of CaCO3 nanoparticles into CMC/SA/Be hydrogel beads significantly enhanced phosphate adsorption. The kinetics of methylene blue (MB) adsorption by hydrogel beads followed the pseudo-second-order model, while phosphate adsorption followed the Elovich model. Furthermore, Langmuir isotherm fitted the phosphate adsorption by CMC/SA/Be/CaCO3 hydrogel beads, indicating improved phosphate adsorption through chemical interaction.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Joanna Potas, Emilia Szymanska, Magdalena Wroblewska, Izabela Kurowska, Mateusz Maciejczyk, Anna Basa, Eliza Wolska, Agnieszka Zofia Wilczewska, Katarzyna Winnicka
Summary: The study developed antifungal multilayer systems composed of chitosan and pectin, showing intelligent pH-responsive properties and strong antifungal effects. The systems exhibited good release kinetics and mucoadhesion properties in a buccal mucosa model, with antifungal activity against Candida strains. The addition of chitosan improved the drug's antifungal behavior, suggesting potential utilization in resistant cases of oral candidiasis.
Article
Polymer Science
Yi-Wei Chen, Muhammad Haseeb Iqbal, Florent Meyer, Vincent Ball, Fouzia Boulmedais
Summary: The surface properties of biomaterials are crucial for cell behavior. Collagen-based layer-by-layer films were constructed using different macromolecules, such as tannic acid, heparin, and poly(sodium 4-styrene sulfonate). Parameters like pH value, dipping time, and salt concentration were optimized for efficient film buildup. The stability and release of tannic acid from the films were studied, and collagen/tannic acid films showed excellent proliferation of human fibroblasts, supporting their potential as biomedical coatings.
Article
Polymer Science
Biswa P. Das, Marina Tsianou
Summary: Multilayer thin film assembly by the layer-by-layer (LbL) technique is an inexpensive and versatile route for the synthesis of functional nanomaterials. This study achieves exponential growth in clay-containing polyelectrolyte films with high clay loading and tailored properties by incorporating a weak polyelectrolyte and a clay with high charge density and small particle size. The findings include novel pathways to manipulate film characteristics. The presented strategy can lead to novel approaches to fabricate tailor-made nanomaterials for distinct applications.
Article
Chemistry, Physical
Tomasz Kruk, Karolina Chojnacka-Gorka, Marta Kolasinska-Sojka, Szczepan Zapotoczny
Summary: This paper reviews the formation, structure determination, and properties of polyelectrolyte multilayer (PEM) films and capsules that respond to physical, chemical, and biological stimuli. It discusses their applications as microcarriers for controlled release, substrates for controlled cell growth, coatings for enhanced surface adhesion, and self-healing anticorrosive systems. The impacts of various stimuli on the integrity and permeability of the films or capsules shell are presented, along with their applications in controlled drug release, biotechnology, and industrial protective coatings.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Biomedical
David Kilian, Stefan Holtzhausen, Wolfram Groh, Philipp Sembdner, Charis Czichy, Anja Lode, Ralph Stelzer, Michael Gelinsky
Summary: Printing patterns based on sinusoidal curves allows the adjustment of internal geometries and density gradients in biomaterials. The wavelength and amplitude of the sinus curve are varied to control the infill density in scaffolds, and the internal structure is confirmed by X-ray micro computed tomography. This technique fills a technological gap in extrusion printing for freely adjustable and continuously guidable density gradients in all spatial directions.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
David M. Griffin, Mitchell A. Kennedy, Surita R. Bhatia
Summary: The study successfully synthesized nanocrystalline calcium phosphate minerals in commercially available block copolymer gels, forming composites with different crystal structures. These composites contained nano-sized particles of calcium hydrogen phosphate hydrate similar to natural bone apatite and exhibited high storage moduli.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Cell Biology
Mark F. McCarty, Aaron Lerner, James J. DiNicolantonio, Simon B. Iloki-Assanga
Summary: Chronic kidney disease is associated with a significantly increased risk of cardiovascular mortality, vascular calcification, ventricular hypertrophy, and systemic oxidative stress. The elevated levels of hyperphosphatemia and fibroblast growth factor 23 (FGF23) are considered key factors in mediating this risk. These factors can lead to cardiac hypertrophy and oxidative stress, as well as impact mitochondrial function and NADPH oxidase complexes in vascular endothelium. Magnesium has been proposed as a protective factor against the effects of hyperphosphatemia, potentially due to its ability to counteract the increase in mitochondrial membrane potential caused by elevated phosphate levels.
Article
Biochemistry & Molecular Biology
Jo Sing Julia Tang, Aline Debrassi Smaczniak, Lucas Tepper, Sophia Rosencrantz, Mina Aleksanyan, Lars Daehne, Ruben R. Rosencrantz
Summary: This study describes the synthesis of bioinspired glycopolymer electrolytes using protecting group free and aqueous-based methods, fabricated as thin films by Layer-by-Layer self-assembly to serve as scaffolds for liposomes. The results demonstrate the stability and integrity of glycopolymer coatings and embedded liposomes within the physiological pH range.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Jack Campbell, Jordan Abnett, Georgia Kastania, Dmitry Volodkin, Anna S. Vikulina
Summary: Polymer layer-by-layer assembly is a promising method for advanced drug delivery platforms and biomimetic materials, but the design of biopolymer capsules poses challenges. This study examines the formation mechanism of multilayer biocapsules templated upon CaCO3 crystals and evaluates the structure-property relationship of capsules made of different biopolymers.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Zhaowei Ou, Baokun Liang, Zihao Liang, Fanglin Tan, Xin Dong, Li Gong, Pei Zhao, Honglei Wang, Yuhai Zou, Yuanjun Xia, Xudong Chen, Wei Liu, Haoyuan Qi, Ute Kaiser, Zhikun Zheng
Summary: This study presents a general strategy for the creation of 2D crystals of covalent organic frameworks (COFs) on the water surface, assisted by a charged polymer. Thin films of 2D COFs with large single-crystalline domains have been achieved, and key factors in the formation of larger single-crystalline domains are revealed. The synthesis method shows a high level of generality and has potential for further investigation and applications in electronics.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Liangliang Fu, Qin Zhao, Jiaojiao Li, Zifan Zhao, Min Wang, Huifang Sun, Haibin Xia
Summary: The heterogeneity of fibroblasts has a direct impact on tissue regeneration outcomes. This study investigated the temporal and spatial distribution of fibroblasts around bioactive ceramics and their effect on bone marrow mesenchymal stem cells (BMSCs). The results showed that the ceramics inhibited fibroblast proliferation but promoted migration, and the conditioned medium from treated fibroblasts enhanced osteogenic differentiation of BMSCs.
Article
Dentistry, Oral Surgery & Medicine
Bo Wen, Liisa Kuhn, Lyndon Charles, David Pendrys, David Shafer, Martin Freilich
CLINICAL ORAL IMPLANTS RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Marja M. Hurley, Gloria Gronowicz, Li Zhu, Liisa T. Kuhn, Craig Rodner, Liping Xiao
JOURNAL OF CELLULAR BIOCHEMISTRY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Isabelle Denry, Liisa T. Kuhn
Article
Pharmacology & Pharmacy
Min Sung Suh, Jie Shen, Liisa T. Kuhn, Diane J. Burges
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Cell & Tissue Engineering
Gloria Gronowicz, Emily Jacobs, Tao Peng, Li Zhu, Marja Hurley, Liisa T. Kuhn
TISSUE ENGINEERING PART A
(2017)
Article
Engineering, Biomedical
Jumana R. Alhamdi, Tao Peng, Iman M. Al-Naggar, Kelly L. Hawley, Kara L. Spiller, Liisa T. Kuhn
Article
Chemistry, Physical
Jumana Alhamdi, Emily Jacobs, Gloria Gronowicz, Nadia Benkirane-Jessel, Marja Hurley, Liisa Kuhn
Article
Engineering, Biomedical
Libo Zhou, Anne Yau, Hongchuan Yu, Liisa Kuhn, Wei Guo, Yupeng Chen
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2020)
Editorial Material
Biotechnology & Applied Microbiology
Hasan Uludag, Abhay Pandit, Liisa Kuhn
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Engineering, Biomedical
Liisa T. Kuhn, Tao Peng, Gloria Gronowicz, Marja M. Hurley
Summary: Endogenous levels of fibroblast growth factor-2 (FGF-2) decrease with age, and a personalized medicine approach should guide FGF-2 supplementation to avoid excessive bone resorption and cartilage formation, which both inhibit calvarial bone repair.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Nanoscience & Nanotechnology
Libo Zhou, Wuxia Zhang, Jinhyung Lee, Liisa Kuhn, Yupeng Chen
Summary: This study developed an injectable nanomatrix (NM) scaffold with a layer-by-layer structure inside each nanosized fiber for highly localized drug delivery and a homeostatic microenvironment, successfully generating highly organized structures via molecular self-assembly.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Bo Wen, David Shafer, Peter Schleier, David Pendrys, Liisa Kuhn, Martin Freilich
CLINICAL ORAL IMPLANTS RESEARCH
(2017)
Article
Engineering, Biomedical
Morteza Haeri, Karen Sagomonyants, Mina Mina, Liisa T. Kuhn, A. Jon Goldberg
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2017)
Article
Integrative & Complementary Medicine
Gloria Gronowicz, Eric R. Secor, John R. Flynn, Liisa T. Kuhn
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2016)