Article
Multidisciplinary Sciences
Kosei Nagata, Hironori Hojo, Song Ho Chang, Hiroyuki Okada, Fumiko Yano, Ryota Chijimatsu, Yasunori Omata, Daisuke Mori, Yuma Makii, Manabu Kawata, Taizo Kaneko, Yasuhide Iwanaga, Hideki Nakamoto, Yuji Maenohara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuki Taniguchi, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito
Summary: The transcription factors Runx2 and Runx3 play different roles in the development of osteoarthritis. Runx3 protects articular cartilage by regulating the expression of lubricin and aggrecan, while Runx2 exerts biphasic effects on osteoarthritis development under different conditions.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Angela Fernandez-Iglesias, Rocio Fuente, Helena Gil-Pena, Laura Alonso-Duran, Fernando Santos, Jose Manuel Lopez
Summary: The study investigated the formation of the epiphyseal bone plate using various microscopy techniques and found that the bone tissue is generated through a process different from the usual endochondral ossification. Osteoblasts deposit bone matrix on various surfaces, leading to the establishment of a core of bone sheet and subsequent thickening and reshaping. The processes occur in close relationship with cartilage, providing insight into the complex cellular events underlying bone formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Andres Pazos-Perez, Maria Pineiro-Ramil, Eloi Franco-Trepat, Maria Guillan-Fresco, Veronica Lopez-Lopez, Alberto Jorge-Mora, Ana Alonso-Perez, Rodolfo Gomez
Summary: The study found that methylphenidate hydrochloride (MPH) may have an impact on the growth plate, leading to premature closure and growth retardation in patients with attention deficit hyperactivity disorder treated with MPH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
E. Andres Sastre, K. Maly, M. Zhu, J. Witte-Bouma, D. Trompet, A. M. Boehm, B. Brachvogel, C. A. van Nieuwenhoven, C. Maes, G. J. V. M. van Osch, F. Zaucke, E. Farrell
Summary: Endochondral ossification plays a key role in skeletal development, with thrombospondin-4 identified as a novel factor involved in bone formation that may promote blood vessel invasion during ossification.
Review
Orthopedics
M. Lauwers, A. Courties, J. Sellam, C. Wen
Summary: This review outlines the involvement of the cholinergic system in joint homeostasis and osteoarthritis, including the role of the cholinergic anti-inflammatory pathway, the impact of cholinergic stimulation on chondrocyte proliferation and differentiation, and the regulation of subchondral bone homeostasis by the cholinergic system. The potential of acetylcholinesterase inhibitors as disease-modifying drugs for OA is also discussed.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Cell Biology
Chee Ho H'ng, Ashwini Khaladkar, Alberto Rosello-Diez
Summary: The balance of cell proliferation and size is crucial for organ development and repair. The mechanistic target of rapamycin (mTOR) signaling pathway, which interacts with other pathways and influences cell proliferation, size, and differentiation, plays a critical role in coordinating the complex developmental transitions during limb development. Therefore, studying the interaction of mTOR components with signaling pathways and transcription factors involved in limb patterning, morphogenesis, and growth could enhance our understanding of these processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xinsheng Zhu, Yong Xu, Xiaoxiong Xu, Junjie Zhu, Linsong Chen, Yawen Xu, Yang Yang, Nan Song
Summary: The use of bevacizumab-laden nanofiber can potentially help regulate the submuscular stability of bone marrow stem cells (BMSCs) engineered cartilage (BEC) to repair tracheal cartilage defects by inhibiting vascular invasion and promoting cartilage maturation.
Review
Endocrinology & Metabolism
Pierre Le Pabic, Daniel. B. B. Dranow, Diego. J. J. Hoyle, Thomas. F. F. Schilling
Summary: Research on the genetic mechanisms underlying human skeletal development and disease have increasingly turned to zebrafish as a model organism. Despite anatomical differences, the conservation of cell types and genetic pathways in cartilage and bone development between teleost fish and humans has been highlighted. Recent studies have shown the importance of cartilage polarity, early establishment of signaling systems, and cartilage proliferation in zebrafish skeletal research. These findings provide valuable insights into the causes and potential therapies for human endochondral bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Naoki Kubo, Tetsuya Awada, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Eri Tsuboi, Daiki Kita, Shota Ito, Ayaka Nakatani, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto
Summary: Estrogen suppresses mandibular growth in a dose-dependent manner, with high doses leading to a significant increase in growth hormone and influencing endochondral ossification.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Inho Baek, Alvin Bacero Bello, Jieun Jeon, Yoshie Arai, Byung-Hyun Cha, Byoung Ju Kim, Soo-Hong Lee
Summary: This study compared the characteristics of epiphyseal growth plate cells (EGPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) and found that EGPCs showed better performance in chondrogenesis and osteogenesis. Additionally, EGPCs were able to promote the expression of bone and hypertrophic markers in BM-MSCs. In an osteoporosis model, EGPCs also demonstrated superior bone regeneration.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Endocrinology & Metabolism
Nicole Bell, Sanket Bhagat, Shanmugam Muruganandan, Ryunhyung Kim, Kailing Ho, Rachel Pierce, Elena Kozhemyakina, Andrew B. Lassar, Laura Gamer, Vicki Rosen, Andreia M. Ionescu
Summary: This study investigates the role of FoxA factors in chondrocyte differentiation and hypertrophy. The researchers found that overexpression of FoxA2 led to skeletal defects and accumulation of hypertrophic chondrocytes in transgenic mice. However, the ectopic expression of hypertrophic markers was only observed in hypertrophic chondrocytes, suggesting the involvement of other factors like Runx2 in inducing chondrocyte hypertrophy.
Article
Orthopedics
Marjolein M. J. Caron, Bert van Rietbergen, Tessy M. R. Castermans, Mirella J. J. Haartmans, Lodewijk W. van Rhijn, Tim J. M. Welting, Adhiambo M. A. Witlox
Summary: The study suggests that naproxen and MTX have an impact on endochondral ossification, leading to impaired skeletal development.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Orthopedics
Christian R. D'Andrea, Ausilah Alfraihat, Anita Singh, Jason B. Anari, Patrick J. Cahill, Thomas Schaer, Brian D. Snyder, Dawn Elliott, Sriram Balasubramanian
Summary: This paper discusses the effects of mechanical loading on macro-scale bone growth alterations and factors affecting growth plate material properties. Findings indicate that growth plate morphology and viability are influenced by loading parameters.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Endocrinology & Metabolism
Mari Satoh, Yukihiro Hasegawa
Summary: Bone age is an important marker of bone maturation, influenced by various hormones including estrogens. Females generally have more advanced bone maturation than males. This study reviews the factors affecting bone age progression, as well as bone maturation and deformities in certain medical conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rotem Kalev-Altman, Jerome Nicolas Janssen, Nir Ben-Haim, Tamar Levy, Astar Shitrit-Tovli, Joshua Milgram, Ron Shahar, Dalit Sela-Donenfeld, Efrat Monsonego-Ornan
Summary: The gelatinases MMP2 and MMP9 play distinct roles in skeletal development, with MMP2 involved in intramembranous ossification and MMP9 affecting endochondral ossification. Double knockout mice lacking both gelatinases show phenotypes resembling the single knockout mice, indicating the separate control of different bones by each gelatinase.