Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 29, Issue 7-9, Pages 917-931Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2017.1383020
Keywords
Micro-stereolithography (MSTL); poly(propylene fumarate) (PPF); macroporous scaffold; RGD peptide; chondrocytes; proliferation; cartilage tissue engineering
Funding
- Korea Health Industry Development Institute (KHIDI) [HI14C3228]
- National Research Foundation of Korea (NRF) [2016R1D1A1B04935153, 2015R1A6A1A03032522, 2016K1A4A3914725]
- National Research Foundation of Korea [2016K1A4A3914725, 2015R1A6A1A03032522, 2015R1D1A1A01058890, 2016R1D1A1B04935153, 2015-DD-RD-0069] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Poly(propylene fumarate) (PPF) has known to be a good candidate material for cartilage tissue regeneration because of its excellent mechanical properties during its degradation processes. Here, we describe the potential application of PPF-based materials as 3D printing bioinks to create macroporous cell scaffolds using micro-stereolithography. To improve cell-matrix interaction of seeded human chondrocytes within the PPF-based 3D scaffolds, we immobilized arginine-glycine-aspartate (RGD) peptide onto the PPF scaffolds. We also evaluated various cellular behaviors of the seeded chondrocytes using MTS assay, microscopic and histological analyses. The results indicated that PPF-based biocompatible scaffolds with immobilized RGD peptide could effectively support initial adhesion and proliferation of human chondrocytes. Such a 3D bio-printable scaffold can offer an opportunity to promote cartilage tissue regeneration.
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