Article
Biotechnology & Applied Microbiology
Tengyu Geng, Yiru Wang, Kaili Lin, Cheng Zhang, Jing Wang, Ya Liu, Changyong Yuan, Penglai Wang
Summary: The hydrothermal treatment of Sr-doped nanocoating significantly promotes bone integration in the osteoporosis environment, providing an effective approach for improving implant surface osseointegration in this context.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ran Yan, Jinhua Li, Qianju Wu, Xiangkai Zhang, Longwei Hu, Yuwei Deng, Ruixue Jiang, Jin Wen, Xinquan Jiang
Summary: The deteriorated bone quality in osteoporosis poses challenges for successful implants, emphasizing the need for early osseointegration and long-term antibacterial properties. This study explores the angiogenic effects of bioactive strontium ions and their potential role in promoting osteogenesis. By screening different doses of strontium ions, researchers developed a bioactive titanium surface augmented with zinc and strontium, which exhibited enhanced osteogenic differentiation and antimicrobial properties. The modified titanium implant surfaces showed improved bone formation and bone-implant contact, suggesting the potential of zinc- and strontium-augmented surfaces for osseointegration in osteoporosis.
FRONTIERS IN CHEMISTRY
(2022)
Review
Engineering, Biomedical
Siyi Wang, Xiao Zhao, Yuchien Hsu, Yunjiao He, Feilong Wang, Fan Yang, Fanyu Yan, Dandan Xia, Yunsong Liu
Summary: Titanium and titanium alloys are commonly used in dental implants, but their inert surface leads to delayed osseointegration. Magnesium ions, known for promoting bone regeneration, have been extensively studied for surface modification of titanium implants. This systematic review summarizes the methods, effects, and clinical applications of magnesium-containing coatings for titanium implant surface modification.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Coatings & Films
Maria Rosa Katunar, Juan Ignacio Pastore, Adrian Cisilino, Julieta Merlo, Leandro Salemme Alonso, Matias Baca, Kahlil Haddad, Silvia Cere, Josefina Ballarre
Summary: This study assessed the in vivo performance of a surface modification consisting of a bioactive silica-based layer with strontium-doped bioactive glass particles on titanium nail-shaped implants in osteoporotic rats. The results showed that the bioactive Sr-glass coatings had a positive effect on new bone tissue formation.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biotechnology & Applied Microbiology
Jie Wang, Baohui Yang, Shuai Guo, Sen Yu, Haopeng Li
Summary: In this study, a novel sandblasting surface modification process was used to manufacture titanium alloy materials with bioactive sandblasted surfaces, and their surface morphology and physicochemical properties were systematically characterized. The osseointegration between titanium alloy materials with bioactive sandblasted surfaces and bone interfaces was analyzed and evaluated through in vitro experiments with osteoblast co-culture and in vivo experiments with a rabbit model. The results showed that the titanium alloy material with bioactive sandblasted surface exhibited satisfactory bioactivity and osteoinductivity, promoting trabecular bone growth on its surface and improving the osseointegration between the material and bone interface.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Xiao Wang, Jingshu Guo, Jin Wen, Xiangkai Zhang, Lingyan Cao, Deliang Zeng, Xuanyong Liu, Xinquan Jiang
Summary: The study successfully enhanced the bioactivity of PEEK implants by applying dual Sr/Si ion modification, promoting osseointegration and accelerating bone formation. This has the potential to be widely adopted in the dental field under osteoporotic conditions.
MATERIALS & DESIGN
(2021)
Article
Materials Science, Multidisciplinary
Yiguo Shen, Kun Wang, Weiliang Wu, Wei Feng, Jiansong Chen, Qiang Gao
Summary: A medical composite coating with antibacterial property and improved osseointegration ability was prepared by depositing Titania (TiO2) microporous/nanofiber coating and strontium (Sr)-doped coating on titanium (Ti) material, and then depositing vancomycin (Van) onto the surface. The coating showed a 99.99% killing effect on methicillin-resistant Staphylococcus aureus (MRSA) and promoted the adhesion and proliferation of osteoblasts. It also induced the formation of bone apatite in simulated body fluid (SBF) test quickly and demonstrated effective infection prevention and excellent osteointegration in vivo.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Physical
Jingjing Bian, Tong Wu, Qiyue Zhou, Haifeng Xie, Chen Chen
Summary: This study aimed to improve the osseointegration of titanium implants in a diabetic microenvironment by developing a local drug delivery system using antioxidants and osteogenic substances. The researchers successfully constructed a coating with good biocompatibility and excellent performance, which promoted cell adhesion and proliferation and improved mitochondrial function.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Jeong Min Kwak, Jungho Kim, Chung-Sung Lee, Il-Soo Park, Min Lee, Dal-Hee Min, In-Sung Luke Yeo
Summary: Graphene oxide has promoting effects on bone marrow stromal cells and human gingival fibroblasts, significantly enhancing osseointegration on titanium surfaces. Physicochemical modification of titanium surfaces with SLA treatment and GO coating stimulates osteogenic activities of mesenchymal stem cells, improving biocompatibility with connective tissue cells and enhancing bone healing at the bone-implant interface.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Ya-nan Wang, Lu Yu, Ting Wang, Shiyue Liu
Summary: This study investigated the effect of ApoE on bone marrow mesenchymal stem cells (BMMSCs) cultured on titanium surface and the osseointegration of titanium implants. The results showed that ApoE supplementation significantly promoted bone integration and inhibited adipogenesis. These findings reveal the potential mechanism of ApoE in improving the osseointegration of titanium implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Xiao Sheng, Ao Wang, Zhonghan Wang, He Liu, Jincheng Wang, Chen Li
Summary: This article discusses the principles, processes, and challenges of surface modification of 3D printed titanium alloy implants. Future research directions, such as the combination of multiple modification technologies and the coordination of the structure and composition of composite coatings, are also presented.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
X. Yu, B. Feng, Y. Lan, J. Li, G. Ye, Q. Li, F. Zhao, Y. Gu, D. You, Y. Zhu, M. Yu, H. Wang, H. Yang
Summary: This study aims to design a personalized two-stage root analog implant (RAI) with a compact structure and uniform roughness to achieve better fracture resistance, initial osseointegration efficiency, and dispersed stress in immediate implantation. RAIs were manufactured using selective laser melting technology, and in vivo experiments showed that they had higher bone-implant contact and bone volume/total volume compared to conventional implants. Customized abutments were also designed for the RAIs, improving the masticatory ability of the beagle dogs.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Lei Wang, Xin Yang, Weiwei Zheng, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Chao Wang, Haoran Lin, Pingbo Chen, Tingjun Ye, Xing Yang, Qiang Wang
Summary: A multifunctional coating integrated with bioactive Sr2+ and antibacterial Cu2+ was successfully fabricated on PEEK implants, which can regulate macrophage subtypes, promote osteogenic differentiation, and provide antibacterial properties, essential for long-term successful implantation.
MATERIALS TODAY ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Yaoyao Yang, Xin Huang, Qianqian Zhang, Dehua Zheng, Wen Gong, Shuqiang Niu, Yanling Yu, Yu Song
Summary: Patients with osteoporosis often experience surgical failure after oral implantation due to low bone density and poor bone healing ability. This study investigated the effect of new-type implants on osseointegration in osteoporotic rats. The results showed that the implants induced more new bone formation and tighter osseointegration, suggesting a potential new strategy for implant surgery in osteoporosis patients.
MATERIALS TODAY COMMUNICATIONS
(2022)