Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells

IL-6 roles – Molecular pathway and clinical implication in pancreatic cancer – A systemic review

(2017) Vlad-Vasile Pop et al.   IMMUNOLOGY LETTERS

MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding

(2016) I. Made Winarsa Ruma et al.   CLINICAL & EXPERIMENTAL METASTASIS

Toll-like receptor 2 signalling: Significance in megakaryocyte development through wnt signalling cross-talk and cytokine induction

(2016) Ram Babu Undi et al.   CYTOKINE

CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma

(2016) Guoqing Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor

(2016) S Nodomi et al.   ONCOGENE

Interaction of the Oncofetal Thomsen–Friedenreich Antigen with Galectins in Cancer Progression and Metastasis

(2016) Paulina Sindrewicz et al.   Frontiers in Oncology

CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development

(2015) Tao Tu et al.   CELL RESEARCH

A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response

(2015) Rina Ulmansky et al.   JOURNAL OF IMMUNOLOGY

The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma

(2015) J Wang et al.   ONCOGENE

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis

(2015) Carrie A Duckworth et al.   Oncotarget

Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis

(2014) S. Kitazume et al.   GLYCOBIOLOGY

CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation

(2014) Nathalie Jouve et al.   INTERNATIONAL JOURNAL OF CANCER

Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium

(2013) C. Chen et al.   CLINICAL CANCER RESEARCH

CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis

(2012) T. Jiang et al.   BLOOD

CD146, a multi-functional molecule beyond adhesion

(2012) Zhaoqing Wang et al.   CANCER LETTERS

The Involvement of CD146 and Its Novel Ligand Galectin-1 in Apoptotic Regulation of Endothelial Cells

(2012) Nathalie Jouve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS

(2012) Ken Flanagan et al.   PLoS One

Galectin-3 – A jack-of-all-trades in cancer

(2011) Anna U. Newlaczyl et al.   CANCER LETTERS

Serum Galectin-2, -4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium

(2011) H. Barrow et al.   CLINICAL CANCER RESEARCH

Novel Interaction of MUC4 and Galectin: Potential Pathobiological Implications for Metastasis in Lethal Pancreatic Cancer

(2010) S. Senapati et al.   CLINICAL CANCER RESEARCH

Interleukin-6 in bone metastasis and cancer progression

(2010) Tasnim Ara et al.   EUROPEAN JOURNAL OF CANCER

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis

(2010) Qicheng Zhao et al.   Molecular Cancer

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Endothelial Cells: Markers and Mediators of Vascular Damage

(2010) Uta Erdbruegger et al.   Current Stem Cell Research & Therapy

Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface

(2009) Q. Zhao et al.   CANCER RESEARCH

Serum Galectin-1 and Galectin-3 Levels in Benign and Malignant Nodular Thyroid Disease

(2008) Sven Saussez et al.   THYROID