Article
Biochemistry & Molecular Biology
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing Su
Summary: The expression levels of GPER1 are found to be associated with tumor type and survival rates in esophageal carcinoma. In overall esophageal carcinoma, low expression of GPER1 is correlated with poor survival rates, while overexpression of GPER1 is associated with the development of esophageal adenocarcinoma and its pre-cancerous lesion. Furthermore, the protein expression of GPER1 is higher in esophageal adenocarcinoma tissues compared to normal esophageal tissues, whereas it is lower in esophageal squamous cell carcinoma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Zulqurnain Haider, Amirhossein Sahebkar, Ali H. Eid
Summary: Atherosclerosis is a major cause of cardiovascular disease-related morbidity and mortality, with higher mortality rates in men than women. It has been suggested that estrogen plays a protective role in the cardiovascular system through the membranous G-protein coupled estrogen receptor, GPER1. Activation of GPER1 regulates vascular smooth cell phenotype and reduces LDL levels by promoting LDL receptor expression and facilitating LDL re-uptake in liver cells. Selective activation of GPER1 may be a promising strategy to prevent or suppress atherosclerosis with fewer side effects compared to non-selective estrogen.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shafi Ullah Khan, Nafees Ahemad, Lay-Hong Chuah, Rakesh Naidu, Thet Thet Htar
Summary: Cancer ranks second among the cause of death worldwide. In this study, a combination of virtual screening techniques and molecular dynamics simulations were used to identify potential GPER modulators with novel structures, which could be used as the core for the development of new anticancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Shuai Liu, Fangyi Chen, Yuanyuan Zhang, Ling Cai, Wenhui Qiu, Ming Yang
Summary: This study successfully obtained the full-length sequence of GPER1 in red common carp and revealed its potential role in regulating environmental estrogen induced immunotoxicity. Through cloning, expression pattern analysis, and functional validation, the study elucidated the mechanism of action of GPER1 in this process.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Johanna Loris, Lena Hanesch, Gerd Bauerschmitz, Julia Gallwas, Carsten Gruendker
Summary: GPER1 appears to have a tumor-suppressive effect in vulvar carcinoma, and its tumorigenic potential can be reduced by activation with agonist G1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xiaowu Wang, Jipeng Ma, Shuaishuai Zhang, Zilin Li, Ziwei Hong, Liqing Jiang, Weixun Duan, Jincheng Liu
Summary: The incidence of cardiovascular diseases increases in postmenopausal women, and the protective role of estrogen in the cardiovascular system has been studied for decades. This research focuses on the protective effects of GPR30 in cardiovascular diseases, particularly in relation to ERK1/2-mediated MMP-9 signaling and cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Maryam Ahmadian Elmi, Nasrin Motamed, Didier Picard
Summary: This study identified the interactome of GPER1 using APEX2-mediated proximity labeling and immunoprecipitation followed by mass spectrometry, and found 73 novel potential interactors. It was found that the GPER1 interactome is not affected by estrogen, and validated the interactions of CLPTM1, PRKCSH, GANAB, and STIM1 with GPER1. These new interactors have implications in membrane protein maturation, trafficking, and calcium signaling.
Article
Cell Biology
Narantsog Choijookhuu, Makoto Ikenoue, Koichi Yano, Yu Yamaguma, Shinichiro Shirouzu, Kengo Kai, Takumi Ishizuka, Yoshitaka Hishikawa
Summary: This study investigates the role of estrogen in colitis and finds that estrogen can improve colonic epithelial barrier function by regulating histone modification, cell proliferation, and CDX2 expression.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Ziwei Tang, Qifu Li, Qingfeng Cheng, Mei Mei, Ying Song, Zhipeng Du, Wenwen He, Jinbo Hu, Shumin Yang, Zhihong Wang
Summary: The study demonstrated that GPER1 can partially mediate aldosterone-induced endothelial inflammatory response, which may involve the PI3K pathway signaling. Suppression of MR did not affect the expression of GPER1, while aldosterone induction promoted the expression of MR.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohadeseh Chahkandi, Gholamreza Komeili, Gholamreza Sepehri, Mohammad Khaksari, Sedigheh Amiresmaili
Summary: This study examined the interference of marijuana and estrogen (E2) on spatial learning and memory in young female rats, finding that they interact in affecting spatial learning and memory, with GPR30 seemingly playing no role in this interaction.
Article
Neurosciences
Kyle Pemberton, Martina Rosato, Cass Dedert, Chelsea DeLeon, Christopher Arnatt, Fenglian Xu
Summary: Estrogen plays important roles in nervous system development and function. The activation of GPER has differential effects on rat hippocampal and cortical neurons, with a stronger response observed in hippocampal neurons. The GPER-mediated increase in Ca2+ in hippocampal neurons involves both the release of intracellular Ca2+ stores and the entry of extracellular Ca2+ through Ca2+ channels.
Article
Environmental Sciences
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, Jose-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Summary: 17 beta-estradiol protects pancreatic beta-cells from apoptosis via estrogen receptors ER alpha, ER beta, and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA) increases basal apoptosis in the same cell type through the same estrogen receptors. The molecular events that trigger these opposite actions have not been identified yet.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Prarthana Gopinath, Revathi Paramasivam Oviya, Gopal Gopisetty
Summary: Estrogen plays a significant role in tumorigenesis, but some breast cancer patients develop resistance to estrogen. Non-classical estrogen signaling through various pathways is important in cancer development and clinical treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang
Summary: BBR is a modulator of GPER1 that inhibits the viability, migration, and autophagy of MDA-MB-231 cells, dependent on estrogen levels. It binds to GPER1 directly, changes its structure, and inhibits the NF-κB pathway, showing anti-cancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Liu-kun Yang, Liang Lu, Jiao Yue, Xin-shang Wang, Jing-yu Qi, Fan Yang, Shui-bing Liu
Summary: The study demonstrated that microglial GPR30 protects neurons from excitotoxicity by modulating M1/M2 polarization, reducing over-phagocytosis. These findings reveal the important role of microglial GPR30 in neurodegenerative diseases.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Caitlin Collin, Frank Hauser, Peter Krogh-Meyer, Karina K. Hansen, Ernesto Gonzalez de Valdivia, Michael Williamson, Cornelis J. P. Grimmelikhuijzen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2011)
Article
Biochemistry & Molecular Biology
Caitlin Collin, Frank Hauser, Ernesto Gonzalez de Valdivia, Shizhong Li, Julia Reisenberger, Eva M. M. Carlsen, Zaid Khan, Niels O. Hansen, Florian Puhm, Leif Sondergaard, Justyna Niemiec, Magdalena Heninger, Guilin R. Ren, Cornelis J. P. Grimmelikhuijzen
CELLULAR AND MOLECULAR LIFE SCIENCES
(2013)
Article
Biotechnology & Applied Microbiology
Nguyen Thanh Nhan, Ernesto Gonzalez de Valdivia, Martin Gustavsson, Truong Nam Hai, Gen Larsson
MICROBIAL CELL FACTORIES
(2011)
Article
Cell Biology
Viktoria Hessle, Petra Bjork, Marcus Sokolowski, Ernesto Gonzalez de Valdivia, Rebecca Silverstein, Konstantin Artemenko, Anu Tyagi, Gianluca Maddalo, Leopold Ilag, Roger Helbig, Roman A. Zubarev, Neus Visa
MOLECULAR BIOLOGY OF THE CELL
(2009)
Article
Oncology
Rebecca A. Silverstein, Ernesto Gonzalez de Valdivia, Neus Visa
MOLECULAR CANCER RESEARCH
(2011)
Article
Biochemistry & Molecular Biology
Viktoria Hessle, Anne von Euler, Ernesto Gonzalez de Valdivia, Neus Visa
Article
Biochemistry & Molecular Biology
Ernesto Gonzalez de Valdivia, Caroline Sanden, Robin Kahn, Bjorn Olde, L. M. Fredrik Leeb-Lundberg
BIOSCIENCE REPORTS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Ernesto Gonzalez de Valdivia, Stefan Broselid, Robin Kahn, Bjorn Olde, Fredrik L. M. Leeb-Lundberg
Article
Microbiology
Mirjana Macvanin, Ernesto I. Gonzalez de Valdivia, David H. Ardell, Leif A. Isaksson
JOURNAL OF BACTERIOLOGY
(2007)
Article
Biochemistry & Molecular Biology
HN Jin, Q Zhao, EI Gonzalez de Valdivia, DH Ardell, M Stenström, LA Isaksson
MOLECULAR MICROBIOLOGY
(2006)
Article
Biochemistry & Molecular Biology
EIG de Valdivia, LA Isaksson
Article
Biochemistry & Molecular Biology
EIG de Valdivia, LA Isaksson
NUCLEIC ACIDS RESEARCH
(2004)