Development of novel biosensors to study receptor-mediated activation of the G-protein α subunits Gsand Golf

Evidence against dopamine D1/D2 receptor heteromers

(2015) A L Frederick et al.   MOLECULAR PSYCHIATRY

Structural basis for nucleotide exchange in heterotrimeric G proteins

(2015) R. O. Dror et al.   SCIENCE

Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling

(2015) Keqiang Xie et al.   eLife

Mutations inGNAL

(2014) Kishore R. Kumar et al.   JAMA Neurology

Role of Gα(olf) in familial and sporadic adult-onset primary dystonia

(2013) Satya R. Vemula et al.   HUMAN MOLECULAR GENETICS

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Mutations in GNAL cause primary torsion dystonia

(2012) Tania Fuchs et al.   NATURE GENETICS

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

(2011) Eneko Urizar et al.   Nature Chemical Biology

Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers

(2011) Kou Qin et al.   Nature Chemical Biology

Structural flexibility of the G s  -helical domain in the  2-adrenoceptor Gs complex

(2011) G. H. Westfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein   Subunit Membrane Association

(2011) M. Gabay et al.   Science Signaling

Identification of a Specific Assembly of the G Protein Golf as a Critical and Regulated Module of Dopamine and Adenosine-Activated cAMP Pathways in the Striatum

(2011) Denis Hervé   Frontiers in Neuroanatomy

Purification of Heterotrimeric G Protein α Subunits by GST-Ric-8 Association

(2010) PuiYee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine A2AReceptor Signaling and GolfAssembly Show a Specific Requirement for the γ7Subtype in the Striatum

(2010) William F. Schwindinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling

(2009) Daniel J Mandell et al.   NATURE METHODS

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY