Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain

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Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O 2

(2016) Stefanie Schwab et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1

(2015) M. Jake Pushie et al.   INORGANIC CHEMISTRY

The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy

(2015) Helena Öhrvik et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Convergent evolution of the genomes of marine mammals

(2015) Andrew D Foote et al.   NATURE GENETICS

Copper transport and regulation inSchizosaccharomyces pombe

(2015) Jude Beaudoin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1

(2014) Helena Öhrvik et al.   Annals of the New York Academy of Sciences

Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

(2014) Elena V. Polishchuk et al.   DEVELOPMENTAL CELL

Lysosome-related Organelles as Mediators of Metal Homeostasis

(2014) Crysten E. Blaby-Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas

(2014) Anne Hong-Hermesdorf et al.   Nature Chemical Biology

Genomic basis for the convergent evolution of electric organs

(2014) J. R. Gallant et al.   SCIENCE

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

(2013) Xiubo Du et al.   CHEMICAL COMMUNICATIONS

Rate and Regulation of Copper Transport by Human Copper Transporter 1 (hCTR1)

(2013) Edward B. Maryon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide signatures of convergent evolution in echolocating mammals

(2013) Joe Parker et al.   NATURE

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

(2013) H. Ohrvik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds

(2013) J. Projecto-Garcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neofunctionalization of young duplicate genes in Drosophila

(2013) R. Assis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Mammalian Diving Capacity Traced by Myoglobin Net Surface Charge

(2013) S. Mirceta et al.   SCIENCE

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evolution of Copper Transporting ATPases in Eukaryotic Organisms

(2012) Arnab Gupta et al.   CURRENT GENOMICS

Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains

(2012) Andreas Brust et al.   MOLECULAR & CELLULAR PROTEOMICS

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Molecular phylogenetics: principles and practice

(2012) Ziheng Yang et al.   NATURE REVIEWS GENETICS

Coordination chemistry of copper proteins: How nature handles a toxic cargo for essential function

(2011) Jeffrey T. Rubino et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Inorganic polyphosphates are stored in spherites within the midgut of Anticarsia gemmatalis and play a role in copper detoxification

(2011) F.M. Gomes et al.   JOURNAL OF INSECT PHYSIOLOGY

Model Peptides Provide New Insights into the Role of Histidine Residues as Potential Ligands in Human Cellular Copper Acquisition via Ctr1

(2011) Kathryn L. Haas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The copper regulon of the human fungal pathogen Cryptococcus neoformans H99

(2011) Chen Ding et al.   MOLECULAR MICROBIOLOGY

Acidocalcisomes as Calcium- and Polyphosphate-Storage Compartments during Embryogenesis of the Insect Rhodnius prolixus Stahl

(2011) Isabela Ramos et al.   PLoS One

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(2010) H. Kaessmann   GENOME RESEARCH

TheDrosophilaCopper Transporter Ctr1C Functions in Male Fertility

(2010) Dominik Steiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wilson Disease at a Single Cell Level

(2010) Martina Ralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I)

(2010) Jeffrey T. Rubino et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Tryptophan Scanning Analysis of the Membrane Domain of CTR-Copper Transporters

(2010) Christopher J. De Feo et al.   JOURNAL OF MEMBRANE BIOLOGY

Ctr1 transports silver into mammalian cells

(2010) Jesse Bertinato et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

A comparison of methionine, histidine and cysteine in copper(i)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments

(2010) Jeffrey T. Rubino et al.   Metallomics

Copper Transporter 2 Regulates Endocytosis and Controls Tumor Growth and Sensitivity to Cisplatin In Vivo

(2010) B. G. Blair et al.   MOLECULAR PHARMACOLOGY

Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict

(2010) C. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Copper Transporter 1 LackingO-Linked Glycosylation Is Proteolytically Cleaved in a Rab9-positive Endosomal Compartment

(2009) Edward B. Maryon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper-dependent Recycling of hCTR1, the Human High Affinity Copper Transporter

(2009) Shannon A. Molloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional structure of the human copper transporter hCTR1

(2009) C. J. De Feo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an ancient adaptive episode of convergent molecular evolution

(2009) T. A. Castoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular multitasking: The dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance

(2008) Svetlana Lutsenko et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells

(2008) Jesse Bertinato et al.   BIOCHEMICAL JOURNAL

EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates

(2008) A. J. Vilella et al.   GENOME RESEARCH

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species

(2008) Bart Hooghe et al.   NUCLEIC ACIDS RESEARCH