The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding

(2015) Melissa A. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

(2015) Brian J. Conti et al.   MOLECULAR CELL

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Cotranslational protein folding on the ribosome monitored in real time

(2015) W. Holtkamp et al.   SCIENCE

Cytosolic Quality Control of Mislocalized Proteins Requires RNF126 Recruitment to Bag6

(2014) Monica C. Rodrigo-Brenni et al.   MOLECULAR CELL

Cotranslational folding inhibits translocation from within the ribosome–Sec61 translocon complex

(2014) Brian J Conti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

(2013) Natalie V Pfeiffer et al.   EMBO JOURNAL

The α-Helical Structure of Prodomains Promotes Translocation of Intrinsically Disordered Neuropeptide Hormones into the Endoplasmic Reticulum

(2013) Daniela Dirndorfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

Design Principles of Protein Biosynthesis-Coupled Quality Control

(2012) Monica C. Rodrigo-Brenni et al.   DEVELOPMENTAL CELL

Position-dependent Effects of Polylysine on Sec Protein Transport

(2012) Fu-Cheng Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Positive charges on the translocating polypeptide chain arrest movement through the translocon

(2012) Hidenobu Fujita et al.   JOURNAL OF CELL SCIENCE

Fumarase: a paradigm of dual targeting and dual localized functions

(2011) Ohad Yogev et al.   FEBS Journal

Polytopic membrane protein folding at L17 in the ribosome tunnel initiates cyclical changes at the translocon

(2011) Pen-Jen Lin et al.   JOURNAL OF CELL BIOLOGY

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

Protein translocation across the ER membrane

(2010) Richard Zimmermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Quality and quantity control at the endoplasmic reticulum

(2010) Ramanujan S Hegde et al.   CURRENT OPINION IN CELL BIOLOGY

Wild-type Shadoo proteins convert to amyloid-like forms under native conditions

(2010) Nathalie Daude et al.   JOURNAL OF NEUROCHEMISTRY

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel

(2010) Shashi Bhushan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic prion protein induces forebrain neurotoxicity

(2009) Xinhe Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Close encounters of the third kind: disordered domains and the interactions of proteins

(2009) Peter Tompa et al.   BIOESSAYS

Translocation of proteins through the Sec61 and SecYEG channels

(2009) Elisabet C Mandon et al.   CURRENT OPINION IN CELL BIOLOGY

α-Helical Domains Promote Translocation of Intrinsically Disordered Polypeptides into the Endoplasmic Reticulum

(2009) Margit Miesbauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Charged Amino Acids in a Preprotein Inhibit SecA-Dependent Protein Translocation

(2009) Nico Nouwen et al.   JOURNAL OF MOLECULAR BIOLOGY

Control of Translocation through the Sec61 Translocon by Nascent Polypeptide Structure within the Ribosome

(2008) Colin J. Daniel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The concept of translocational regulation

(2008) Ramanujan S. Hegde et al.   JOURNAL OF CELL BIOLOGY

Malleable machines take shape in eukaryotic transcriptional regulation

(2008) Monika Fuxreiter et al.   Nature Chemical Biology

The Recognition and Retrotranslocation of Misfolded Proteins from the Endoplasmic Reticulum

(2008) Kunio Nakatsukasa et al.   TRAFFIC

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry