Article
Plant Sciences
Jingru Li, Wenqiang Pan, Jiahui Liang, Chang Liu, Danqing Li, Yingdong Yang, Lianwei Qu, Sonia Gazzarrini, Mingfang Yi, Jian Wu
Summary: Bud dormancy is a crucial trait in geophytes that affects their flowering and growth patterns. In Gladiolus, the release of corm dormancy is promoted by repressing ABA biosynthesis and signaling, which is regulated by GhBPC2. GhBPC2 controls the expression of GhABI5 and recruits PRC2 and GhEBS to epigenetically regulate corm dormancy release.
Article
Cell Biology
Zhaowei Tu, Cuiqing Fan, Ashely K. Davis, Mengwen Hu, Chen Wang, Akhila Dandamudi, Katie G. Seu, Theodosia A. Kalfa, Q. Richard Lu, Yi Zheng
Summary: This study identifies CHD8 as an essential regulator of erythroid differentiation and cytokinesis in red blood cells. Loss of CHD8 leads to decreased numbers of red blood cells and abnormalities in cell division.
Article
Cell Biology
Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Yasmina Curto, Nadine Barnkothe, Imam Hassouna, Sebastian Jahne, Umer Javed Butt, Katharina Grewe, Martin S. Weber, Kim Green, Silvio Rizzoli, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Summary: Research shows that in the adult hippocampus, EPO expression promotes the differentiation of new neurons, increases dendritic spine density, and is associated with a decrease in microglia numbers.
Article
Microbiology
Taylor Van Gundy, Edward Martin, Jeremy Bono, Olivia Hatton, Meghan C. Lybecker
Summary: In this study, we report the functional characterization of an antisense RNA (aMEF) that acts as a dual regulator for the mazEF toxin-antitoxin system. Unlike other antisense RNAs, aMEF stimulates the synthesis and translation of mazEF instead of inhibiting and degrading it. Furthermore, our findings suggest that the lack of conservation of antisense RNA promoters does not necessarily correlate with their functionality.
Article
Microbiology
Taylor Van Gundy, Edward Martin, Jeremy Bono, Olivia Hatton, Meghan C. Lybecker
Summary: This study elucidates the function of an antisense RNA (aMEF) and demonstrates that pervasive transcripts can be functional, despite the ongoing controversy regarding their regulatory roles. Further research is needed to fully understand the extent of functional antisense RNAs in gene regulation.
Article
Biochemistry & Molecular Biology
He Leng, Shaofeng Liu, Yang Lei, Yuantao Tang, Shijia Gu, Jiazhi Hu, She Chen, Jianxun Feng, Qing Li
Summary: The study identified an interaction between the histone chaperone FACT and the Set3 histone deacetylase complex (Set3C), revealing their collaboration in regulating gene expression. Set3C is shown to prevent uncontrolled GAL10 ncRNA expression and fine-tune the expression of GAL genes upon a change in carbon source.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemical Research Methods
Pramod Sahadevan, Bruce G. Allen
Summary: Cardiac fibroblasts play a critical role in maintaining the extracellular matrix, wound healing, and cardiac interstitial fibrosis. A method for isolating and maintaining these fibroblasts in vitro allows for a better understanding of their biology and response to fibrotic stimuli.
Article
Microbiology
Ningkun Liu, Yanzhuo Xu, Qi Li, Yuxin Cao, Dechang Yang, Shasha Liu, Xiaokang Wang, Yingjie Mi, Yang Liu, Chenxi Ding, Yan Liu, Yong Li, Yao-Wu Yuan, Ge Gao, Jinfeng Chen, Weiqiang Qian, Xiaoming Zhang
Summary: A long non-coding RNA called SABC1 has been discovered to play a crucial role in balancing plant immunity and growth. SABC1 suppresses plant immunity and promotes growth by regulating the neighboring gene NAC3. This lncRNA acts as a molecular switch in modulating the production of salicylic acid, a key molecule in plant defense against pathogens.
CELL HOST & MICROBE
(2022)
Article
Biochemistry & Molecular Biology
Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh
Summary: Cadmium exerts its cytotoxicity through the inhibition of MEF2A activity and suppression of GLUT4 expression, leading to reduced cellular glucose concentration and ATP levels. This study provides a crucial breakthrough in understanding the mechanism of Cd toxicity in renal cells.
Article
Neurosciences
Jinsong Yu, Ke Xiao, Xiaohua Chen, Lulu Deng, Lu Zang, Yue Li, Anran Gao, Junjun Gao, Chengchao Wu, Xinmei Yang, Qiudi Zhou, Jian Yang, Chenyu Bao, Jiaji Jiao, Sheng Cheng, Zhiqing Guo, Weize Xu, Xiaojian Cao, Zheng Guo, Jinxia Dai, Ji Hu, Zhenfan Fu, Gang Cao
Summary: The nervous and immune systems are connected, with NPY playing a role in regulating immune responses and immune balance. This ancient language of communication between the nervous and immune systems could potentially be utilized to alleviate inflammation during infection and modulate immune balance in autoimmune diseases.
Article
Cell Biology
Zeyun Hao, Jinfu Tian, Hong Fang, Liang Fang, Xiao Xu, Feng He, Shaoya Li, Wenya Xie, Qiang Du, Xiaoman You, Debao Wang, Qiuhong Chen, Ruyi Wang, Shimin Zuo, Meng Yuan, Guo-Liang Wang, Lanqin Xia, Yuese Ning
Summary: A ubiquitin E3 ligase-VQ protein-transcription factor module has been discovered to fine-tune plant immunity and growth by regulating gene expression at the transcriptional and posttranslational levels.
Article
Cell Biology
Amira Moustafa, Sara Hashemi, Gurnoor Brar, Jorg Grigull, Siemon H. S. Ng, Declan Williams, Gerold Schmitt-Ulms, John C. McDermott
Summary: Transcriptional regulators encoded by the MEF2 gene family have a fundamental role in cardiac development, homeostasis, and pathology. Through a systematic screen, we identified a dynamic interaction between MEF2A and STAT3 proteins, which play an important role in the regulation of inflammation and cardiomyocyte cell survival. This study provides information about the MEF2A protein interactome in cardiomyocytes, enhancing our understanding of the hierarchical control of gene expression in normal and pathophysiological conditions.
CELL DEATH & DISEASE
(2023)
Review
Immunology
Shiyu Liu, Benqi Huang, Jingdong Cao, Yifei Wang, Hao Xiao, Yaxi Zhu, Huali Zhang
Summary: The redox state is crucial to cell fate, and reactive oxygen species (ROS) as important signaling molecules play a pivotal role in immune cell homeostasis and the pathological processes of various diseases. This review discusses the mechanisms and signaling pathways by which ROS regulate the proliferation, differentiation, polarization, and function of immune cells, including T cells, B cells, neutrophils, macrophages, MDSCs, and DCs. Additionally, we highlight how excessive ROS can lead to programmed immune cell death, such as apoptosis, ferroptosis, pyroptosis, NETosis, and necroptosis, providing valuable insights for future therapeutic strategies in human diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Berta Victoria, Sarah. A. A. Noureddine, Michael. G. G. Shehat, Travis. J. J. Jewett, Mollie. W. W. Jewett
Summary: The colonization of human skin by Borrelia burgdorferi after a tick bite is the initial step in the development of Lyme disease. MicroRNAs, specifically miR146a-5p, are found to play a role in the early immune response to B. burgdorferi infection. Through analysis of host transcriptional responses and co-culture models, it was confirmed that miR146a-5p is an important regulator of the inflammatory profile during early B. burgdorferi infection.
Article
Microbiology
Amarendranath M. Soory, Girish M. Ratnaparkhi
Summary: Post-translational modification by SUMO can modulate the activity of proteins. In Drosophila, the transcription factor Jra is identified as a SUMO target. Loss of Jra changes the gut immune gene regulatory network, while SUMOylation strengthens the immune response.