Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

(2015) Nazma Malik et al.   BIOCHEMICAL JOURNAL

TLR8 SensesStaphylococcus aureusRNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

(2015) Bjarte Bergstrøm et al.   JOURNAL OF IMMUNOLOGY

An Anti-Urokinase Plasminogen Activator Receptor Antibody (ATN-658) Blocks Prostate Cancer Invasion, Migration, Growth, and Experimental Skeletal Metastasis In Vitro and In Vivo

(2015) Shafaat A. Rabbani et al.   NEOPLASIA

The Clathrin-Mediated Endocytic Pathway Participates in dsRNA-Induced IFN-  Production

(2014) K. Itoh et al.   JOURNAL OF IMMUNOLOGY

Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing

(2014) Yusuke Murakami et al.   JOURNAL OF IMMUNOLOGY

SARM Regulates CCL5 Production in Macrophages by Promoting the Recruitment of Transcription Factors and RNA Polymerase II to the Ccl5 Promoter

(2014) C. Gurtler et al.   JOURNAL OF IMMUNOLOGY

The Ectodomain of TLR3 Receptor Is Required for Its Plasma Membrane Translocation

(2014) Jelka Pohar et al.   PLoS One

Cancer: A Tale of Aberrant PRR Response

(2014) Raunaq Singh Nagi et al.   Frontiers in Immunology

The Role of Toll-Like Receptors in Colorectal Cancer Progression: Evidence for Epithelial to Leucocytic Transition

(2014) Kimberly A. Luddy et al.   Frontiers in Immunology

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity

(2013) Ricardo Rajsbaum et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF- B and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection

(2013) J. Brownell et al.   JOURNAL OF VIROLOGY

The Yin and Yang of Toll-like receptors in cancer

(2013) J-P Pradere et al.   ONCOGENE

Epigenetic and genetic features of 24 colon cancer cell lines

(2013) D Ahmed et al.   Oncogenesis

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

(2012) Y S Lee et al.   BRITISH JOURNAL OF CANCER

The Critical Role of Dysregulated FOXM1-PLAUR Signaling in Human Colon Cancer Progression and Metastasis

(2012) D. Li et al.   CLINICAL CANCER RESEARCH

Enhanced Expression of CXCL10 in Inflammatory Bowel Disease

(2012) Ann E. Østvik et al.   INFLAMMATORY BOWEL DISEASES

The Role of UNC93B1 Protein in Surface Localization of TLR3 Receptor and in Cell Priming to Nucleic Acid Agonists

(2012) Jelka Pohar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Processing Regulates Toll-like Receptor 3 Stability and Endosomal Localization

(2012) Rongsu Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

(2012) Jamie J Bernard et al.   NATURE MEDICINE

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticancer function of polyinosinic-polycytidylic acid

(2011) Yu-sheng Cheng et al.   CANCER BIOLOGY & THERAPY

TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

(2011) B. Salaun et al.   CANCER RESEARCH

The dual role of TLR3 in metastatic cell line

(2011) Tanja Matijevic et al.   CLINICAL & EXPERIMENTAL METASTASIS

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antiviral responses induced by the TLR3 pathway

(2011) Misako Matsumoto et al.   REVIEWS IN MEDICAL VIROLOGY

Beyond the enhanceosome: cluster of novel  B sites downstream of the human IFN-  gene is essential for lipopolysaccharide-induced gene activation

(2010) F. G. Goh et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Tumor necrosis is a new promising prognostic factor in colorectal cancer

(2010) Marion J. Pollheimer et al.   HUMAN PATHOLOGY

Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models

(2010) Yan Ning et al.   INTERNATIONAL JOURNAL OF CANCER

Secretion of the Human Toll-like Receptor 3 Ectodomain Is Affected by Single Nucleotide Polymorphisms and Regulated by Unc93b1

(2010) Rongsu Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repression of IP-10 by Interactions between Histone Deacetylation and Hypermethylation in Idiopathic Pulmonary Fibrosis

(2010) W. R. Coward et al.   MOLECULAR AND CELLULAR BIOLOGY

Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-κB-dependent activation of the urokinase plasminogen activator system

(2009) S D Killeen et al.   BRITISH JOURNAL OF CANCER

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC- -dependent mechanism

(2008) A. Paone et al.   CARCINOGENESIS

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

RNAi-mediated downregulation of urokinase plasminogen activator receptor inhibits proliferation, adhesion, migration and invasion in oral cancer cells

(2008) Xinhua Liang et al.   ORAL ONCOLOGY

The TLR3 signaling complex forms by cooperative receptor dimerization

(2008) J. N. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of HCT116 Human Colon Cancer Cells in an Orthotopic Model

(2007) Ashwani Rajput et al.   JOURNAL OF SURGICAL RESEARCH