Lipid stress inhibits endocytosis of melanocortin-4 receptor from modified clathrin-enriched sites and impairs receptor desensitization

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

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Membrane fission by dynamin: what we know and what we need to know

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Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway

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Hypothalamic ER stress: A bridge between leptin resistance and obesity

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Gq/11α and Gsα mediate distinct physiological responses to central melanocortins

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Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists

(2015) Brent M. Molden et al.   MOLECULAR ENDOCRINOLOGY

Mild Lipid Stress Induces Profound Loss of MC4R Protein Abundance and Function

(2014) Faith K. Cragle et al.   MOLECULAR ENDOCRINOLOGY

Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits

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Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize

(2013) S. Granell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gsα Deficiency in the Paraventricular Nucleus of the Hypothalamus Partially Contributes to Obesity Associated with Gsα Mutations

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Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH)

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From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

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Obesity is associated with hypothalamic injury in rodents and humans

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Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

Palmitate impairs cytokinesis associated with RhoA inhibition

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The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons

(2010) Ginah L. Kim et al.   ENDOCRINOLOGY

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

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