Journal
JOURNAL OF BIOCHEMISTRY
Volume 162, Issue 2, Pages 73-80Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvx036
Keywords
amyloid beta; leukocyte Ig-like receptors; MHC class I; Nogo; paired Ig-like receptor
Categories
Funding
- JSPS KAKENHI [JP25460601, 16K09703]
- Grants-in-Aid for Scientific Research [16K09703] Funding Source: KAKEN
Ask authors/readers for more resources
Leukocyte Ig-like receptors (LILRs)/Ig-like transcripts (ILTs) are expressed on innate and adaptive immune cells and maintain immune homeostasis. LILRs consist of activating and inhibitory-type receptors that regulate adequate cellular functions. LILRs were firstly identified as MHC class I receptors, therefore expression and/or polymorphisms of LILRs are reported to associate with autoimmune disorders and transplant rejection; however, recent accumulating evidences have revealed that LILRs recognize with diverse ligands including bacteria and virus. In addition, inhibitory LILRB2 (ILT4) and murine relative paired Ig-like receptor (PIR)-B are expressed on neuron and is involved in the dysregulation of central nervous system via interaction with neuronal ligands including amyloid beta-protein. In this review, we summarize recent discoveries on the functions of inhibitory MHC class I receptors, and discuss their regulatory roles in immune responses and neural functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available