Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 32, Issue 4, Pages 429-442Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911516686090
Keywords
Tracheomalacia; airway stent; digital light procession three-dimensional printing; acrylate; collagen
Funding
- National Key Research and Development Program [2016YFC1100704]
- National Natural Science Foundation of China [11120101001, 11421202, 61227902]
- Research Found for the Doctoral Program of Higher Education of China [20131102130004]
- Beijing Municipal Science and Technology Project [Z151100003715006, Z141107002514073]
- National Basic Research Program of China (973 program) [2011CB710901]
- National Key Technology RD Program [2014BAI11B15]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding [ZYLX201508]
- Capital Health Research and Development of Special Funding [2014-1-2091]
- 111 Project of China [B13003]
- Capital Health Research and Development of Special Funding Support [2014-1-2091]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201508]
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Recently, more and more researchers have focused on airway stent applied in tracheomalacia. The airway stents for clinical application were usually manufactured in accordance with a fixed pattern, which were difficult to perfect match with children, especially infants. Digital light procession of light curing acrylate resin implantation showed higher accuracy and printing speed over traditional three-dimensional printing techniques. In this article, a novel personalized airway stent was developed by digital light procession three-dimensional printing and was modified by collagen I extracted from the fish scales. The morphology of the collagen-modified airway stent was examined by scanning electron microscopy, and the chemical structures were examined by attenuated total internal reflectance Fourier transform infrared spectroscopy. The biocompatibility of this synthetic acrylate/collagen composite airway stent was characterized by water contact angle test and cell culture. The results confirmed that the composite airway stent was hydrophilic and non-cytotoxic toward a cultured human bronchial epithelial cell line with good cell viability and show excellent physicochemical and biological properties. In conclusion, this study presented the three-dimensional printing composite acrylate and collagen airway stent may have potential in customized treatment for tracheomalacia.
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