Article
Allergy
Komal Agrawal, Li Ching Ong, Susan Monkley, Kristofer Thorn, Elisabeth Israelsson, Engin Baturcam, Cassie Rist, Karin Schon, Sophia Blake, Bjorn Magnusson, James Cartwright, Suman Mitra, Abilash Ravi, Nazanin Zounemat-Kermani, Jayendra Kumar Krishnaswamy, Nils Y. Lycke, Ulf Gehrmann, Johan Mattsson
Summary: Patients with asthma experience reduced ability to clear respiratory viral infections due to changes in gene expression in nasal and lung epithelial cells. These changes interfere with the development of lung resident memory T cells, which may contribute to the increased susceptibility of patients with asthma to viral exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Lin, Fei Dai, Jinjin Wei, Zheng Chen
Summary: CD8(+) Tregs have not been clearly elucidated in allergic rhinitis (AR), but this study found that CD8(+) Tregs may help alleviate inflammatory responses in AR condition. Percentages of CD4(+) or CD8(+) Tregs in PBMCs from AR patients were reduced compared to normal subjects, but IL-10 and TGF-beta were increased in CD4(+) and CD8(+) Tregs cultures from AR patients.
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Naoya Imahashi, Masashi Satoh, Emanuela Clemente, Kazuhisa Yoshino, Mario Di Gioacchino, Kazuya Iwabuchi
Summary: Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells involved in host defense and immune-mediated diseases. MHC-related protein 1 (MR1) selects MR1-restricted T cells, including mucosal-associated invariant T (MAIT) cells, and presents ligands to them. This study found that MR1-deficient mice exhibited exaggerated allergic contact dermatitis (ACD) lesions with increased recruitment of neutrophils. Additionally, MR1-deficient mice lacking MAIT cells showed an increase in IL-17-producing αβ and γδ T cells in the skin.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yimin Guo, Jianting Shi, Qiujie Wang, Luna Hong, Ming Chen, Shanying Liu, Xiaoqing Yuan, Shanping Jiang
Summary: Obese asthmatic mice showed more severe airway inflammation and significant changes in inflammatory cytokines. Metformin reversed obesity, alleviated airway inflammation and remodeling with increased Tregs, suggesting potential anti-inflammatory effects through Treg modulation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Lorena Abreu Fernandes, Augusto Cesar Penalva de Oliveira, Youko Nukui, Jorge Casseb, Fernando Roberto Machado Cunha, Luiz Henrique da Silva Nali, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study found that IgG obtained from HAM/TSP and ATLL patients can differentially modulate the cytokine production by human T and B cells, and elicit distinct effects on target populations.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Yanghe Liu, Chen Zhang, Bing Li, Chen Yu, Xiaocui Bai, Chunying Xiao, Lei Wang, Erle Dang, Luting Yang, Gang Wang
Summary: IL-17A inhibits the suppressive function of Tregs by blocking TGF-beta release and promoting IFN-gamma production. Treatment with anti-IL-17A in psoriasis patients restores the suppressive function of Tregs.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Immunology
Huilei Zhang, Shuangqing Liu, Yanan Li, Jianru Li, Chen Ni, Ming Yang, Jun Dong, Zhaoqing Wang, Zhihai Qin
Summary: The study reveals that S100A4 drives dysfunction in CD8(+) T-EM cells, leading to the loss of their protective memory response and promoting asthma worsening. CD8(+) T-EM cells can be divided into dysfunctional subsets and subsets inclined towards apoptosis based on the expression of S100A4. S100A4 affects mitochondrial metabolism, leading to a decrease in acetyl-CoA levels, which impairs the transcription of effector genes (especially IFN-γ), facilitating cell survival, tolerance, and memory potential.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Alexis Yero, Tao Shi, Jean-Pierre Routy, Cecile Tremblay, Madeleine Durand, Cecilia T. T. Costiniuk, Mohammad-Ali Jenabian
Summary: This study found that acute and chronic HIV infection are associated with an increase in total, effector memory, and terminally differentiated FoxP3(+) CD8 T-cells. Early antiretroviral therapy (ART) only normalized the frequencies of total FoxP3(+) CD8 T-cells. The study also observed increased immune activation, senescence, and PD-1 expression in FoxP3(+) CD8 T-cells during acute and chronic infection, which were not normalized by early ART.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Allergy
Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner, Evgeniya Petrova, Lam C. Tsoi, Olivier Gouin, Florent Leturcq, Pascale Nicaise-Roland, Christine Bole, Vivien Beziat, Emmanuelle Bourrat, Oliver Schilling, Johann E. Gudjonsson, Alain Hovnanian
Summary: This study comprehensively characterizes the skin, immune cells, and allergic phenotypes of Netherton syndrome through multiple molecular profiling methods. The results reveal abnormal epidermal proliferation and differentiation, as well as IL-17/IL-36 signatures in both NS-ILC and NS-SE. Distinct molecular features are found between nonlesion and lesion skin of each disease subtype. Serum cytokine profiling and immunophenotyping show different allergic responses in NS-ILC and NS-SE patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Dermatology
Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura
Summary: In human psoriasis, PD-1 expressing CD8(+) CD103(+) T cells in the skin are associated with disease severity and histopathology, indicating a potential pathogenic subset that may play a role in psoriasis pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amanda Goulart, Medeton Mahoussi Michael Boko, Nubia Sabrina Martins, Ana Flavia Gembre, Romulo Silva de Oliveira, Sandra Patricia Palma-Albornoz, Thais Bertolini, Paulo Eduardo Martins Ribolla, Leandra Naira Zambelli Ramalho, Thais Fernanda de Campos Fraga-Silva, Vania Luiza Deperon Bonato
Summary: IL-22 plays a pro-inflammatory role in allergic asthma, contributing to the recruitment and activation of eosinophils. The absence of IL-22 reduces eosinophil number and cytokine production, as well as mucus production and pulmonary inflammation. Transfer of Th17 cells from IL-22 deficient mice also affects eosinophil frequency in the airways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Summary: Murine IL-17-producing γδT (γδT17) cells consist of natural γδT17 (nγδT17) cells and inducible γδT17 cells. IL-21 is dispensable for the fetal thymic development of nγδT17 cells, but required for the peripheral maintenance of Vδ4(+)nγδT17 cells.
FRONTIERS IN IMMUNOLOGY
(2023)