Article
Endocrinology & Metabolism
Nan Jia, Haoying Hao, Cuilian Zhang, Juanke Xie, Shaodi Zhang
Summary: The quality and morphological grade of blastocysts have an impact on the perinatal outcomes of frozen-thawed single blastocyst transfer cycles. Transfer of a good-quality blastocyst is associated with a lower rate of preterm delivery and a higher likelihood of a male neonate. B grade inner cell mass (ICM) blastocyst transfer decreases the rate of preterm delivery, and trophectoderm (TE) quality is positively correlated with the likelihood of a male neonate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Belinda Gia Linh An, Michael Chapman, Liza Tilia, Christos Venetis
Summary: The timing of frozen-thawed embryo transfer within a specific window is associated with higher live birth rates. The impact of the optimal transfer window varies between different embryo transfer cycles.
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Murat Erden, Sezcan Mumusoglu, Mehtap Polat, Irem Yarali Ozbek, Sandro C. Esteves, Peter Humaidan, Hakan Yarali
Summary: This study aims to systematically review the definition of the onset of LH surge and the duration between the LH surge and ovulation in true natural cycle FET. The available literature lacks a consensus on the definition of the onset of the LH surge, with different studies using different criteria. There is significant interpersonal variation in the time interval between the onset of the LH surge and ovulation.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Obstetrics & Gynecology
Prachi Godiwala, Reeva Makhijani, Alison Bartolucci, Daniel Grow, John Nulsen, Claudio Benadiva, James Grady, Lawrence Engmann
Summary: This retrospective cohort study compared the pregnancy outcomes of letrozole ovulation induction, natural cycles, and programmed frozen-thawed embryo transfer (FET) cycles. The results showed that the ongoing pregnancy rate/live birth rate was higher in letrozole FETs than in programmed FETs, but comparable to natural FETs. The ongoing pregnancy rate/live birth rate was comparable between natural and programmed FETs. The clinical loss rate was lower in the natural FET group than in the programmed FET group.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Ziqi Jin, Jingdi Li, EnTong Yang, Hao Shi, Zhiqin Bu, Wenbin Niu, Fang Wang, Mingzhu Huo, Hui Song, YiLe Zhang
Summary: In frozen-thawed euploid blastocyst transfer cycles, higher endometrial thickness change ratio from progesterone administration day to blastocyst transfer day was associated with a higher clinical pregnancy rate, especially in cases where the endometrium did not undergo compaction after progesterone administration.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Shi-Bin Chao, Yan-Hong Wang, Jian-Chun Li, Wen-Ting Cao, Yun Zhou, Qing-Yuan Sun
Summary: This study investigated the impact of a novel endometrial preparation approach (DROI) on the clinical pregnancy rate of single frozen-thawed blastocyst transfer and compared it with hormone replace treatment (HRT). The results showed that the DROI group had significantly higher clinical pregnancy rate and ongoing pregnancy rate compared to the HRT group, suggesting that DROI may be a more efficient and promising alternative for endometrial preparation in frozen-thawed blastocyst transfer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Ziqi Jin, Hao Shi, Manman Lu, Zhiqin Bu, Mingzhu Huo, Yile Zhang
Summary: The study aimed to investigate the relationship between endometrial thickness changes and pregnancy outcomes in single frozen-thawed euploid blastocyst transfer cycles. The results showed that there was no statistically significant correlation between endometrial thickness change ratio and pregnancy outcomes.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Xiaofang Li, Yan'e Gao, Juanzi Shi, Wenhao Shi, Haiyan Bai
Summary: In the comparison of endometrial preparation methods for single euploid frozen blastocyst transfers, natural cycles (NC) were associated with a higher live birth rate and lower total pregnancy loss compared to hormone replacement treatment (HRT). Despite the convenience of HRT, choosing NC as the endometrial preparation method may lead to a higher chance of live birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ya-Wen Hsueh, Chien-Chu Huang, Shuo-Wen Hung, Chia-Wei Chang, Hsi-Chen Hsu, Tung-Chuan Yang, Wu-Chou Lin, Shan-Yu Su, Hsun-Ming Chang
Summary: Frozen-thawed embryo transfer (FET) has become a viable alternative to fresh embryo transfer due to improved vitrification methods. Studies show that hormonal changes during the window of implantation may affect the interaction between the embryo and endometrium, leading to decreased implantation potential. FET has been associated with higher pregnancy rates and better perinatal outcomes, but there is still a need to optimize the endometrial priming protocol.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Dan-Dan Gao, Li Li, Yi Zhang, Xiao-Xuan Wang, Jing-Yan Song, Zhen-Gao Sun
Summary: The study found that in ovulatory patients undergoing FET, live birth rates were significantly higher in natural cycles compared to modified natural cycles. Multivariable analysis also indicated that modified natural cycles were associated with a lower likelihood of live birth. Therefore, for women with regular menstrual cycles, utilizing a natural cycle strategy may increase the chances of successful pregnancy outcomes.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yue Niu, Dingying Zhao, Yuhuan Wang, Lu Suo, Jialin Zou, Daimin Wei
Summary: The study found that for PCOS patients undergoing frozen single-blastocyst transfer cycles, using letrozole or hMG for endometrial preparation ovulation induction regimens is associated with a higher livebirth rate and lower pregnancy loss rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Lena Mensing, Emilie S. Dahlberg, Bjorn Bay, Anette Gabrielsen, Ulla B. Knudsen
Summary: The aim of this study was to compare the outcomes of three endometrial preparation methods prior to frozen embryo transfer (FET): Natural cycle (NC), modified natural cycle (mNC), and programmed/artificial cycle (AC) protocols. The study found that the mNC protocol had better clinical pregnancy rates and live birth rates compared to the NC and AC protocols.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Endocrinology & Metabolism
Wenhao Shi, Hanying Zhou, Lijuan Chen, Xia Xue, Juanzi Shi
Summary: When choosing blastocyst transfer, it is preferable to prioritize high-grade D6 blastocysts over low-grade D5 blastocysts. This is because the live birth rate achieved with high-grade D6 blastocyst transfer is significantly higher than that with low-grade D5 blastocyst transfer in single frozen-thawed blastocyst transfer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Guanling Yu, Shuiying Ma, Hui Liu, Yujin Liu, Haozhen Zhang, Wenjia Zhang, Keliang Wu
Summary: This study analyzed the clinical outcomes of blastocyst after preimplantation genetic testing (PGT) transplantation from frozen-thawed D5 and D6. It also investigated the impact of blastocyst grade on clinical and neonatal outcomes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Freya Waschkies, Luka Kroning, Thilo Schill, Arvind Chandra, Cordula Schippert, Dagmar Toepfer, Yvonne Ziert, Frauke Von Versen-Hoeynck
Summary: This study indicates that the absence of corpora lutea during frozen-thawed embryo transfer (FET) may increase the risk of pregnancy hypertensive disorders and potentially lead to higher birth weights in newborns. Findings suggest a potential link between the lack of CL at conception and adverse maternal and neonatal outcomes. Further research on causes and pathophysiological relationships is needed.
FRONTIERS IN MEDICINE
(2021)