Article
Biochemistry & Molecular Biology
Chow-Seng Kong, Alexandra Almansa Ordonez, Sarah Turner, Tina Tremaine, Joanne Muter, Emma S. Lucas, Emma Salisbury, Rita Vassena, Gustavo Tiscornia, Ali A. Fouladi-Nashta, Geraldine Hartshorne, Jan J. Brosens, Paul J. Brighton
Summary: The study found that uterine natural killer cells play a crucial role in embryo biosensing and implantation process, highlighting their importance in selectively eliminating senescent decidual cells.
Article
Immunology
Yue Li, Si-Ting Chen, Yu-Ying He, Bo Li, Chen Yang, Zhen-Shan Yang, Zeng-Ming Yang
Summary: In this study, the involvement of secreted HMGB1 in early mouse pregnancy was investigated. It was found that HMGB1 can be detected in the uterine lumen fluid and its secretion is influenced by the presence of blastocysts. The presence of trypsin in blastocysts and its ability to stimulate HB-EGF production was also demonstrated. Furthermore, the role of PAR2-HMGB1-ADAM17-HB-EGF signaling pathway in decidualization was identified.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Maria Diniz-da-Costa, Chow-Seng Kong, Katherine J. Fishwick, Thomas Rawlings, Paul J. Brighton, Amelia Hawkes, Joshua Odendaal, Siobhan Quenby, Sascha Ott, Emma S. Lucas, Pavle Vrljicak, Jan J. Brosens
Summary: The study identifies a highly proliferative population of mesenchymal cells (hPMC) in midluteal human endometrium, potentially serving as novel decidual precursors; hPMC differ from endometrial stromal cells in the expression of genes for prolactin and other decidual transcription factors, and show signs of differentiation into a decidual subpopulation discovered in early pregnancy; recurrent pregnancy loss is associated with depletion of hPMC.
Review
Cell Biology
Jan J. Brosens, Phillip R. Bennett, Vikki M. Abrahams, Rosanna Ramhorst, Arri Coomarasamy, Siobhan Quenby, Emma S. Lucas, Rajiv C. McCoy
Summary: Compared to other mammals, human pregnancy is unique in its involvement of chromosomally diverse embryos and the cyclical breakdown and regeneration of the uterine mucosa. Understanding the mechanisms behind miscarriage can provide insights into the maternal selection of embryos during early gestation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Aikaterini Berdiaki, Sophia Zafeiropoulou, Fanourios Makrygiannakis, Panagiotis Drakopoulos, Timur Gurgan, Antonios Makrigiannakis
Summary: Ageing has an impact on the function and gene expression of endometrial stromal cells, which is important for understanding the causes of infertility.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Editorial Material
Biology
J. Julie Kim
Summary: A new laboratory model helps to study the role of senescent cells in fostering a uterine environment that can support an embryo.
Article
Cell Biology
Jing Long, Weike Li, Mengyue Chen, Yubin Ding, Xuemei Chen, Chao Tong, Na Li, Xueqing Liu, Junlin He, Chuan Peng, Yanqing Geng, Taihang Liu, Xinyi Mu, Fangfang Li, Yingxiong Wang, Rufei Gao
Summary: Uterine deficiency of Dnmt3b impairs decidualization and consequent embryo implantation defects. Pgk1 may play a significant role in the decidualization process.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Cell Biology
Vineet K. Maurya, Francesco J. DeMayo, John P. Lydon
Summary: The synchrony between progesterone-driven endometrial receptivity and the arrival of a euploid blastocyst is crucial for successful embryo implantation and establishment of pregnancy. Aberrant progesterone molecular responses can lead to infertility, early embryo miscarriage, gestational complications, and endometrial pathologies. Further identification and functional analysis of key molecular mediators and modifiers of the endometrial response to progesterone may provide insight into early endometrial changes and lead to more effective diagnostics and therapies for female infertility and gynecological morbidities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Jianghong Cheng, Zizhuo Sha, Junyang Li, Bixuan Li, Xianyang Luo, Zhiming Zhang, Yi Zhou, Shuai Chen, Yang Wang
Summary: Embryo implantation and decidualization are vital for successful pregnancy, and defects in these processes can lead to adverse pregnancy outcomes. Around 75% of failed pregnancies are caused by implantation failure or defects. This article reviews recent advances in understanding the molecular mechanisms of estrogen and progesterone regulation in establishing uterine receptivity, blastocyst implantation, and decidualization, with the aim of developing strategies to prevent or treat implantation defects and improve pregnancy rates.
REPRODUCTIVE SCIENCES
(2023)
Article
Reproductive Biology
Susanne C. Grund, Xin Xin Wu, Dominik Mueller, Gunther Wennemuth, Ruth Gruemmer
Summary: Deletion of claudin-3 in the endometrium impairs decidualization and leads to reduced size of implantation sites and fetal weight. Transcription downregulation of various decidua-associated genes may contribute to the impairment of decidualization.
BIOLOGY OF REPRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Manizha Shekibi, Sophea Heng, Guiying Nie
Summary: The development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Recent studies have focused on the role of microRNAs (miRNAs) in the regulation of endometrial receptivity. This review provides an up-to-date knowledge of the miRNAs identified in humans and mice that may play a functional role in the establishment of receptivity. The findings suggest that miRNAs could be potential biomarkers and therapeutic targets for improving endometrial receptivity in human fertility treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Thomas M. Rawlings, Komal Makwana, Deborah M. Taylor, Matteo A. Mole, Katherine J. Fishwick, Maria Tryfonos, Joshua Odendaal, Amelia Hawkes, Magdalena Zernicka-Goetz, Geraldine M. Hartshorne, Jan J. Brosens, Emma S. Lucas
Summary: The study suggests that decidual senescence controls endometrial fate decisions at implantation and the presence of senescent decidual cells creates a dynamic implantation environment, enabling embryo expansion and attachment but leading to gradual disintegration of assembloids. Pharmacological inhibition of stress responses in pre-decidual cells accelerated decidualization and eliminated the emergence of senescent decidual cells, resulting in a strong, static decidual matrix. The research highlights how endometrial assembloids may facilitate the discovery of new treatments to prevent reproductive failure.
Article
Agriculture, Dairy & Animal Science
Lakshmi Devi Huidrom, Shital Nagargoje Dhanaji, Sriti Pandey, Vikash Chandra, Taru Sharma Gutulla
Summary: Early embryonic loss is a major cause of repeat breeding in buffalo. Proper communication between the embryo and maternal system is crucial for successful pregnancy outcomes. The embryo releases specific molecules as signals to the maternal endometrium for survival and continued pregnancy. Understanding the molecular cross-talk between the embryo and uterine endometrium is important for improving IVF outcomes.
Article
Biochemistry & Molecular Biology
Pramod Dhakal, Harriet C. Fitzgerald, Andrew M. Kelleher, Hongyu Liu, Thomas E. Spencer
Summary: The study demonstrated the crucial roles of uterine glands in embryo survival and stromal cell decidualization. Using a glandless FOXA2-deficient mouse model, researchers found compromised embryo survival and decidualization on gestational day 6.5, leading to abrupt pregnancy loss by day 7.5.
Article
Biotechnology & Applied Microbiology
Chen Zhou, Xinyan Cheng, Fanming Meng, Yongzhong Wang, Wanyun Luo, Enqin Zheng, Gengyuan Cai, Zhenfang Wu, Zicong Li, Linjun Hong
Summary: This study analyzed the circRNA expression profile in the pig endometrium during the 12th day of gestation and found that circRNAs are abundantly expressed and play important regulatory roles in related genes. These findings provide insights into the molecular mechanisms contributing to pregnancy establishment and embryo loss in pigs, as well as the molecular pathway differences between breeds during the critical implantation period.
Editorial Material
Obstetrics & Gynecology
M. Van Wely, K. Kirkegaard, C. De Geyter, C. B. Lambalk
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Anne-Lotte L. F. Van der Kooi, Marloes van Dijk, Linda Broer, Marleen H. van den Berg, Joop S. E. Laven, Flora E. van Leeuwen, Cornelis B. Lambalk, Annelies Overbeek, Jacqueline J. Loonen, Helena J. van der Pal, Wim J. Tissing, Birgitta Versluys, Dorine Bresters, Catharina C. M. Beerendonk, Cecile R. Ronckers, Margriet Van der Heiden-van der Loo, Gertjan L. Kaspers, Andrica C. H. de Vries, Leslie L. Robison, Melissa M. Hudson, Wassim Chemaitilly, Julianne Byrne, Claire Berger, Eva Clemens, Uta Dirksen, Jeanette Falck Winther, Sophie D. Fossa, Desiree Grabow, Riccardo Haupt, Melanie Kaiser, Tomas Kepak, Jarmila Kruseova, Dalit Modan-Moses, Saskia M. F. Pluijm, Claudia Spix, Oliver Zolk, Peter Kaatsch, Jesse H. Krijthe, Leontien C. Kremer, Yutaka Yasui, Russell J. Brooke, Andre G. Uitterlinden, Marry M. Van den Heuvel-Eibrink, Eline Van Dulmen-den Broeder
Summary: The study found that female childhood cancer survivors carrying a variant in the BRSK1 gene have an increased likelihood of reduced ovarian function after high-dose alkylating chemotherapy. Further research may help in providing personalized counseling regarding assisted reproductive technology and fertility preservation procedures.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
M. J. Wyrwoll, E. S. van Walree, G. Hamer, N. Rotte, M. M. Motazacker, H. Meijers-Heijboer, M. Alders, A. Meissner, E. Kaminsky, M. Woeste, C. Krallmann, S. Kliesch, T. J. Hunt, A. T. Clark, S. Silber, B. Stallmeyer, C. Friedrich, A. M. M. van Pelt, I. B. Mathijssen, F. Tuettelmann
Summary: The study identified bi-allelic variants in MSH4 and MSH5 as causes of male infertility, expanding the understanding of genetic factors contributing to azoospermia.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
N. E. van Hoogenhuijze, R. van Eekelen, F. Mol, I Schipper, E. R. Groenewoud, M. A. F. Traas, C. A. H. Janssen, G. Teklenburg, J. P. de Bruin, R. H. F. van Oppenraaij, J. W. M. Maas, E. Moll, K. Fleischer, M. H. A. van Hooff, C. H. de Koning, A. E. P. Cantineau, C. B. Lambalk, M. Verberg, A. M. van Heusden, A. P. Manger, M. M. E. van Rumste, L. F. van der Voet, Q. D. Pieterse, J. Visser, E. A. Brinkhuis, J. E. den Hartog, M. W. Glas, N. F. Klijn, M. van der Zanden, M. L. Bandell, J. C. Boxmeer, J. van Disseldorp, J. Smeenk, M. van Wely, M. J. C. Eijkemans, H. L. Torrance, F. J. M. Broekmans
Summary: Endometrial scratch prior to the second fresh IVF/ICSI treatment may increase live birth rate, but comes with higher costs and uncertainty in effectiveness.
HUMAN REPRODUCTION
(2022)
Editorial Material
Obstetrics & Gynecology
Cornelis (Nils) Lambalk
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Nienke van Welie, Joukje van Rijswijk, Kim Dreyer, Machiel H. A. van Hooff, Jan Peter de Bruin, Harold R. Verhoeve, Femke Mol, Wilhelmina M. van Baal, Maaike A. F. Traas, Arno M. van Peperstraten, Arentje P. Manger, Judith Gianotten, Cornelia H. de Koning, Aafke M. H. Koning, Neriman Bayram, David P. van der Ham, Francisca P. J. M. Vrouenraets, Michaela Kalafusova, Bob I. G. van de Laar, Jeroen Kaijser, Arjon F. Lambeek, Wouter J. Meijer, Frank J. M. Broekmans, Olivier Valkenburg, Lucy F. van der Voet, Jeroen van Disseldorp, Marieke J. Lambers, Rachel Tros, Cornelis B. Lambalk, Jaap Stoker, Madelon van Wely, Patrick M. M. Bossuyt, Ben Willem J. Mol, Velja Mijatovic
Summary: HyFoSy and HSG produce similar findings in a majority of patients and clinical management based on the results of either HyFoSy or HSG leads to comparable pregnancy outcomes. HyFoSy is experienced as significantly less painful.
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
K. Rosielle, D. Kamphuis, N. van Welie, I. Roest, A. Mozes, E. J. P. van Santbrink, T. van de Laar, A. B. Hooker, A. G. Huppelschoten, W. Li, M. Y. Bongers, J. Stoker, M. van Wely, C. Koks, C. B. Lambalk, A. Hemingway, B. W. J. Mol, K. Dreyer, V. Mijatovic
Summary: This study aims to compare the fertility-enhancing effect and cost-effectiveness of using oil-based contrast and water-based contrast during hysterosalpingography in women of advanced age, women with ovulatory disorders, and women with a high risk for tubal pathology.
Review
Endocrinology & Metabolism
Iris Sanou, Jillis van Maaren, Jitske Eliveld, Qijing Lei, Andreas Meissner, Annemieke A. de Melker, Geert Hamer, Ans M. M. van Pelt, Callista L. Mulder
Summary: Fertility preservation through biobanking of testicular tissue is recommended for boys undergoing treatment before puberty. However, current fertility therapies using SSCs are still in preclinical phases. Further research and resolution of major issues are needed for optimal clinical implementation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Eva M. E. Balkenende, Taghride Dahhan, Catharina C. M. Beerendonk, Kathrin Fleischer, Dominic Stoop, Annelies M. E. Bos, Cornelis B. Lambalk, Roel Schats, Jesper M. J. Smeenk, Leonie A. Louwe, Astrid E. P. Cantineau, Jan Peter de Bruin, Sabine C. Linn, Fulco van der Veen, Madelon van Wely, Mariette Goddijn
Summary: Alternative ovarian stimulation protocols with tamoxifen or letrozole did not affect the number of cumulus-oocyte complexes (COCs) retrieved at follicle aspiration in women with breast cancer.
HUMAN REPRODUCTION
(2022)
Article
Genetics & Heredity
Rebekka M. Koeck, Florence Busato, Jorg Tost, Dimitri Consten, Jannie Van Echten-Arends, Sebastiaan Mastenbroek, Yvonne Wurth, Sylvie Remy, Sabine Langie, Tim S. Nawrot, Michelle Plusquin, Rossella Alfano, Esmee M. Bijnens, Marij Gielen, Ron van Golde, John C. M. Dumoulin, Han Brunner, Aafke P. A. van Montfoort, Masoud Zamani Esteki
Summary: There were no significant methylation differences in the umbilical cord blood methylome between IVF neonates developed in different IVF culture media, suggesting that the use of different culture media may not affect the epigenetic profile of IVF newborns.
NPJ GENOMIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jan Willem Bruggeman, Jan Koster, Ans M. M. van Pelt, Dave Speijer, Geert Hamer
Summary: This article proposes a hypothesis that activating the germline program promotes cancer cell malignancy. The four hallmark processes of the germline, including meiosis, epigenetic plasticity, migration, and metabolic plasticity, enable germ cells and cancer cells to have replicative immortality. Especially, meiotic genes are frequently expressed in cancer, suggesting their potential role in oncogenesis.
Article
Obstetrics & Gynecology
J. A. Wessel, M. H. Mochtar, D. E. Besselink, H. Betjes, J. P. de Bruin, A. E. P. Cantineau, E. R. Groenewoud, A. B. Hooker, C. B. Lambalk, J. Kwee, E. M. Kaaijk, L. A. Louwe, J. W. M. Maas, B. W. J. Mol, M. M. E. van Rumste, M. A. F. Traas, M. Goddijn, M. van Wely, F. Mol
Summary: In couples with unexplained subfertility and a poor prognosis for natural conception, expectant management (EM) for 6 months is inferior to IUI with ovarian stimulation (IUI-OS) in terms of live births.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
C. H. Statema-Lohmeijer, R. Schats, B. Lissenberg-Witte, E. H. Kostelijk, C. B. Lambalk, C. G. Vergouw
Summary: Does a shorter interval between semen collection and IUI increase the chance of ongoing pregnancy? A long interval resulted in a significant improvement in cumulative ongoing pregnancies and a shorter time to pregnancy.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Felicia Dreischor, Ellen T. M. Laan, Fleur Peeters, Karen Peeraer, Cornelis B. Lambalk, Mariette Goddijn, Inge M. Custers, Eline A. F. Dancet
Summary: Couples hope for fertility clinic staff to incorporate expectant management into the clinic trajectory, interact with both partners, and provide advice on common peer experiences, lifestyle management, distress, and sexual challenges.
HUMAN REPRODUCTION OPEN
(2022)
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Melissa M. Hudson, Hanneke M. van Santen, Erik A. H. Loeffen, Karen C. Burns, Gwendolyn P. Quinn, Eline van Dulmen-den Broeder, Julianne Byrne, Riccardo Haupt, W. Hamish Wallace, Marry M. van den Heuvel-Eibrink, Antoinette Anazodo, Richard A. Anderson, Anke Barnbrock, Joern D. Beck, Annelies M. E. Bos, Isabelle Demeestere, Christian Denzer, Natascia Di Iorgi, Holly R. Hoefgen, Rejin Kebudi, Cornelis Lambalk, Thorsten Langer, Lillian R. Meacham, Kenny Rodriguez-Wallberg, Catharyn Stern, Eveline Stutz-Grunder, Wendy van Dorp, Margreet Veening, Saskia Veldkamp, Eline van der Meulen, Louis S. Constine, Lisa B. Kenney, Marianne D. van de Wetering, Leontien C. M. Kremer, Jennifer Levine, Wim J. E. Tissing
Summary: This study aims to develop clinical practice guidelines for fertility preservation in female patients diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger. By utilizing the Grading of Recommendations Assessment, Development and Evaluation methodology, transparent recommendations were formed to facilitate the care of high-risk female patients. Collaboration led to a comprehensive review of existing evidence, transparent reporting, and achievement of global interdisciplinary consensus.