Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 20, Issue 8, Pages 734-743Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2017.1346630
Keywords
Piperaceae; Piper semiimmersum; aporphine alkaloids; antiplatelet aggregation
Funding
- Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences [Y4ZK111B01]
- Natural Science Foundation of Yunnan Province, China [2011FZ205]
- Minzu University of China [2015MDTD16C, ydzxxk201618]
- Ministry of Science & Technology of China [2012FY110300]
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Two new aporphine alkaloids, semiimmersumines A (1) and B (2), along with 20 known compounds, were isolated from the aerial parts of Piper semiimmersum (Piperaceae). The structures of the new compounds were elucidated based on the analysis of 1D and 2D NMR, MS, and CD data. The absolute configuration of semiimmersumine A (1) was determined by single crystal X-ray diffraction analysis using anomalous dispersion with copper radiation. The effects of all compounds from the plant on rabbit platelet aggregation induced by thrombin (IIa) or PAF were also evaluated. [GRAPHICS] .
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