A new p-hydroxybenzoic acid derivative from an endophytic fungus Penicillium sp of Nerium indicum

A new p-hydroxybenzoic acid derivative named 4-(2 ' R, 4 '-dihydroxybutoxy) benzoic acid (1) was isolated from the fermentation of Penicillium sp. R22 in Nerium indicum. The structure was elucidated by means of spectroscopic (HR-ESI-MS, NMR, IR, UV) and X-ray crystallographic methods. The antibacterial and antifungal activity of compound 1 was tested, and the results showed that compound 1 revealed potent antifungal activity against Colletotrichum gloeosporioides, Alternaria alternata, and Alteranria brassicae with MIC value of 31.2 mu g/ml. [GRAPHICS] .