Article
Biochemistry & Molecular Biology
Hyung-Mun Yun, Mi Hyeon Cho, Hoibin Jeong, Soo Hyun Kim, Yun Hee Jeong, Kyung-Ran Park
Summary: This study investigated the effects of a flavonoid called trifolirhizin (trifol) derived from Sophora flavescens on osteogenic processes during osteoblast differentiation. It was found that trifol promoted osteoblast differentiation markers and stimulated major osteogenic signaling proteins. Trifol also increased osteoblast-mediated bone-forming phenotypes. These findings suggest that trifol may be an effective phytomedicine for bone diseases such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Martin Montecino, Margarita E. Carrasco, Gino Nardocci
Summary: Genomic DNA in the eukaryotic nucleus is organized into chromatin through stable interactions with histone proteins and other nuclear components, contributing to differential control of access to key genetic information. Epigenetic mechanisms, such as DNA methylation and chromatin remodeling, play critical roles in regulating gene expression by modifying chromatin compaction levels for transcription activation and repression. The review discusses evidence supporting the role of these mechanisms in the transcriptional control of osteoblast-related genes, particularly at the Runx2 and Sp7 genes, which encode master regulators of osteogenic lineage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Polymer Science
Parisa Sanaei-rad, Davoud Jamshidi, Mamak Adel, Ehsan Seyedjafari
Summary: The combination of bioceramics and nanofibrous scaffolds shows potential for inducing mineralization in connective tissues. The study investigated the behavior of dental pulp stem cells (DPSC) on mineral trioxide aggregate (MTA) coated poly(l-lactide) (PLLA) nanofibers, showing enhanced odontogenic differentiation with desired characteristics for pulp capping materials.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Cell Biology
Chenglong Wang, Sabine Stoeckl, Shushan Li, Marietta Herrmann, Christoph Lukas, Yvonne Reinders, Albert Sickmann, Susanne Graessel
Summary: This study investigated the effects of extracellular vesicles (EVs) isolated from different stages of human bone marrow mesenchymal stem cells (hBMSCs) on the osteogenic and adipogenic differentiation capacity of naive hBMSCs. The results showed that EVs from late-stage osteogenic differentiated hBMSCs promoted osteogenic potential in naive hBMSCs and inhibited their adipogenic differentiation. Proteomic analysis revealed distinct protein profiles in EVs from osteogenic and naive hBMSCs.
Article
Oncology
Lu Zhang, Guangjun Jiao, Yunhao You, Xiang Li, Jincheng Liu, Zhenqian Sun, Qinghui Li, Zihan Dai, Jinlong Ma, Hongming Zhou, Gang Li, Chunyang Meng, Yunzhen Chen
Summary: In this study, it was discovered that coactivator-associated arginine methyltransferase 1 (CARM1) affects the metabolism of osteoblasts and osteoclasts, thereby promoting osteogenesis and inhibiting osteoclast differentiation. By altering carbohydrate metabolism, CARM1 can reduce bone loss in osteoporosis model mice. These findings may provide a new feasible treatment strategy for osteoporosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Dongdong Fei, Yanmin Xia, Qiming Zhai, Yazheng Wang, Feng Zhou, Wanmin Zhao, Xiaoning He, Qintao Wang, Yan Jin, Bei Li
Summary: This study focuses on the clonal osteogenic heterogeneity of periodontal ligament stem cells (PDLSCs) and uncovers a mechanism where exosome-mediated PINK1/Parkin-dependent mitophagy regulates interclonal communication among SCCs with osteogenic heterogeneity, promoting osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yuqi Zhou, Guifang Wang, Tianqi Wang, Jiajia Wang, Xutao Wen, Haishui Sun, Lei Yu, Xiaoying Liu, Juanjuan Zhang, Qin Zhou, Yan Sun
Summary: In this study, a novel MAO-PDA-NC composite coating was successfully prepared to optimize the physical and chemical properties of titanium implant surface and stimulate osteoblast adhesion, proliferation, and osteogenic differentiation. The coating promoted stable bonding between the implant and bone tissue, accelerating early osseointegration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Chemical
Lorenzo Marchetti, Christopher Hulme-Smith
Summary: This study compared 8 different flowability testing methods using 11 steel powders and found numerical relationships between certain flowability metrics, such as conditioned bulk density and Hausner ratio. The research highlighted the importance of understanding the correlations between different flowability indicators in powder flow behavior analysis.
Article
Construction & Building Technology
Victor Revilla-Cuesta, Marta Skaf, Vanesa Ortega-Lopez, Juan M. Manso
Summary: This paper proposes a multi-parametric flowability classification for Self-Compacting Concrete (SCC) containing sustainable raw materials. By analyzing a dataset of 663 SCC mixes with sustainable aggregates and binders, three types of flowability zones are defined. The classification provides a complete picture of the fresh behavior of SCC, and recommends the application fields for each SCC mix with sustainable raw materials.
JOURNAL OF BUILDING ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Xiaotian Hao, Sheng Miao, Zhiquan Li, Taoran Wang, Baobao Xue, Jingdi Chen, Chunxing Xian, Long Bi
Summary: Porous hydrogel scaffolds with medium pore sizes were prepared using 3D printing technology to study the effect of the 3D printed porous structures on the osteogenic differentiation of BMSCs in hydrogel scaffolds. The results showed that the osteogenic differentiation of BMSCs in the structured porous hydrogels was more prominent compared to the non-porous groups, and the mineralization of the hydrogel scaffolds was also enhanced. The 3D printing-based approach provides a facile strategy for the preparation of hydrogels with intermediate pore structures, promoting the viability and osteogenic differentiation of BMSCs in hydrogel scaffolds.
MATERIALS & DESIGN
(2023)
Article
Multidisciplinary Sciences
Olga S. Yevlashevskaya, Ben A. Scheven, A. Damien Walmsley, Richard M. Shelton
Summary: The present study investigated the response of Saos-2 cells and mesenchymal stromal/stem cells to ascorbic acid, dexamethasone, and beta-glycerophosphate. The results showed that beta-glycerophosphate significantly decreased Saos-2 cell proliferation and upregulated the expression of late osteoblastic markers, suggesting its impact on later stages of osteogenic differentiation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemical Research Methods
Daniela S. C. Bispo, Catarina S. H. Jesus, Marlene Correia, Filipa Ferreira, Giulia Bonifazio, Brian J. Goodfellow, Mariana B. Oliveira, Joao F. Mano, Ana M. Gil
Summary: This article presents the first untargeted nuclear magnetic resonance (NMR) metabolomic characterization of human adipose-derived mesenchymal stem cells during osteogenic differentiation. The results reveal significant changes in metabolism, including amino acid metabolism, protein synthesis, energy metabolism, and antioxidative mechanisms.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Harshavardhan Mohan, Natesan Karthi, Pavithra Muthukumar Sathya, Vaikundamoorthy Ramalingam, Srivalli Thimmarayan, Mohammad Amjad Hossain, Adithan Aravinthan, Taeho Shin
Summary: This study synthesized (Zn, Ni)-ferrite nanoparticles using a chemical co-precipitation method and evaluated their cytotoxicity and osteogenic properties. The results showed that these nanoparticles had low toxicity and could potentially be used as biomaterials in regenerative medicine.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zheng-Yang Chen, Ru-Bing Zhou, Rui-Deng Wang, Shi-Long Su, Fang Zhou
Summary: In this study, a dual-crosslinked network hydrogel (PAM-CMC-10% Aln @ZIF-8) was successfully designed by introducing monomers acrylamide (AM), carboxymethylcellulose (CMC), zeolitic imidazolate framework-8 (ZIF-8), and alendronate (Aln). The hydrogel exhibited excellent mechanical characteristics, high Aln loading efficiency, and a slow release period. Furthermore, the introduction of Aln enabled the hydrogel to possess superior biocompatibility and outstanding osteo-genic differentiation ability in vitro.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Pinar Ercal, Soner Sismanoglu
Summary: This in vitro study investigated the effects of different bioactive root-end filling materials on the osteo/odontogenic differentiation and viability of mesenchymal stem cells (MSCs) from porcine tooth germs. The results showed that all tested materials supported cell proliferation and maintained cell viability. Osteo/odontogenic differentiation of MSCs was promoted by the materials, with Pure Portland Cement demonstrating the highest activity.
APPLIED SCIENCES-BASEL
(2023)
