Article
Endocrinology & Metabolism
Houchen Lyu, Sizheng Zhao, Jiatian Li, Xiaoxiao Li, Yilun Wang, Dongxing Xie, Chao Zeng, Guanghua Lei, Jie Wei, Hui Li
Summary: This study found that denosumab treatment does not significantly increase the susceptibility of community-acquired pneumonia compared to alendronate treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Materials Science, Characterization & Testing
Chunlan Jing, Shenmao Chen, Sehajdev Singh Bhatia, Bowen Li, Hongze Liang, Chaozong Liu, Zhenjiang Liang, Junying Liu, Haiyan Li, Ziyu Liu, Hui Tan, Lingling Zhao
Summary: Bone-targeted polymeric nanoparticles for alendronate delivery were fabricated and shown to have sustained release and good cytocompatibility, with high affinity to bone cells.
Article
Biology
Jing Hu, Bingna Zhou, Xiaoyun Lin, Qian Zhang, Feifei Guan, Lei Sun, Jiayi Liu, Ou Wang, Yan Jiang, Wei-bo Xia, Xiaoping Xing, Mei Li, Mishaela R. Rubin
Summary: PLS3 protein is important for human bone health, and mutations in PLS3 can lead to early-onset osteoporosis. The mechanism of how PLS3 mutation causes osteoporosis is unknown, and effective treatment strategies have not been established.
Review
Medicine, General & Internal
SeokJoon Hwang, Minsu Seo, Dongin Lim, Min Suk Choi, Jin-Woo Park, Kiyeun Nam
Summary: This literature review investigated the characteristics and management of bisphosphonate-associated bilateral atypical femoral fractures (AFFs). A comprehensive analysis of 43 patients with bilateral AFFs revealed that 67% had prodromal symptoms, 49% occurred simultaneously, and 51% occurred sequentially. X-ray was used for initial diagnosis, with 53% having complete fractures. Surgical treatment was performed for all patients, except for those with incomplete fractures who received either surgical or medical treatments. Teriparatide was the most commonly used medication after bisphosphonate discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Zhi-Ming Liu, Min Zhang, Yuan Zong, Ding Zhang, Zhu-Bin Shen, Xiao-Qing Guan, Fei Yin
Summary: This study aimed to compare the efficacy of alendronate and teriparatide in the treatment of glucocorticoid-induced osteoporosis. The study found that compared to alendronate, teriparatide could reduce the rate of new vertebral fractures and increase the bone mineral density of the lumbar spine, femoral neck, and total hip. There was no significant difference in the incidence of non-vertebral fractures and adverse events between the two groups.
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: This study aimed to investigate the risk of major osteoporotic fractures in diabetes patients initiated with alendronate and denosumab. Results showed that the risk of incident major osteoporotic fractures among subjects with diabetes was similar between those initially treated with alendronate and denosumab, suggesting both treatments are equally effective in preventing osteoporotic fractures in subjects with diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
Klemens Vertesich, Branden R. Sosa, Yingzhen Niu, Gang Ji, Vincentius Suhardi, Kathleen Turajane, Sehwan Mun, Ren Xu, Reinhard Windhager, Kyung Hyun Park-Min, Matthew B. Greenblatt, Mathias P. Bostrom, Xu Yang
Summary: The study investigated the short-term effects of postoperative systemic alendronate on osseointegration using a mouse implant model. Results showed that alendronate treatment enhanced osseointegration, increasing bone mass and maximum pullout load, while decreasing peri-implant osteoclasts. This data supports the postoperative clinical use of bisphosphonates, especially in patients with high risks of aseptic loosening.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Biomedical
Wei Jiang, Fushan Hou, Yong Gu, Qimanguli Saiding, Pingping Bao, Jincheng Tang, Liang Wu, Chunmao Chen, Cailiang Shen, Catarina Leite Pereira, Marco Sarmento, Bruno Sarmento, Wenguo Cui, Liang Chen
Summary: This study developed an organic-inorganic dual-adhesive hydrogel using alendronate and methacryloyl hyaluronic acid, which promoted the stability of orthopedic implants under osteoporotic conditions.
BIOACTIVE MATERIALS
(2022)
Article
Endocrinology & Metabolism
Rawan Hikmet, Torben Harslof, Bente Lomholt Langdahl
Summary: This study aimed to compare the effectiveness of buffered and effervescent alendronate (ALN-EFF) with conventional alendronate (ALN) in suppressing bone turnover markers (BTM). The results showed no significant difference in BTM suppression between the two groups, but the non-inferiority of ALN-EFF could not be established.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Cell Biology
Qiyun Zhou, Zhiqiang Guan, Shengfu Liu, Yanjiao Xuan, Gang Han, Hua Chen, Xiao Jin, Kun Tao, Zhiyuan Guan
Summary: The combination of alendronate and metformin has a positive effect on improving glucose metabolism and bone metabolism in diabetic mice. Alendronate significantly increases serum glucagon-like peptide-1 levels, while metformin improves bone microstructure. The combined use of alendronate and metformin shows better anti-diabetes and anti-osteoporotic effects compared to diabetic mice.
Article
Biotechnology & Applied Microbiology
Tengyu Geng, Yiru Wang, Kaili Lin, Cheng Zhang, Jing Wang, Ya Liu, Changyong Yuan, Penglai Wang
Summary: The hydrothermal treatment of Sr-doped nanocoating significantly promotes bone integration in the osteoporosis environment, providing an effective approach for improving implant surface osseointegration in this context.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yaoyao Yang, Xin Huang, Qianqian Zhang, Dehua Zheng, Wen Gong, Shuqiang Niu, Yanling Yu, Yu Song
Summary: Patients with osteoporosis often experience surgical failure after oral implantation due to low bone density and poor bone healing ability. This study investigated the effect of new-type implants on osseointegration in osteoporotic rats. The results showed that the implants induced more new bone formation and tighter osseointegration, suggesting a potential new strategy for implant surgery in osteoporosis patients.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Yanyan Zheng, Ang Gao, Jiaxiang Bai, Qing Liao, Yuzheng Wu, Wei Zhang, Min Guan, Liping Tong, Dechun Geng, Xin Zhao, Paul K. Chu, Huaiyu Wang
Summary: This article introduces a method to design and fabricate a programmable surface on PEEK to sequentially regulate osteoimmunomodulation and bone regeneration, improving the osseointegration of bone implants, especially under osteoporotic conditions.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Gabriel Mulinari-Santos, Jaqueline Silva dos Santos, Igor Lebedenco Kitagawa, Fabio Roberto de Souza Batista, Paulo Roberto Botacin, Cristina Antoniali, Paulo Noronha Lisboa-Filho, Roberta Okamoto
Summary: Hypertension and estrogen deficiency can impair osseointegration, and the use of antihypertensive drugs and alendronate sodium can enhance bone healing. However, estrogen deficiency still affects bone integration even with alendronate coating.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biology
Pedro Henrique Silva Gomes-Ferreira, Paula Buzo Frigerio, Juliana de Moura, Nathalia Dantas Duarte, Danila de Oliveira, Joseph Deering, Kathryn Grandfield, Roberta Okamoto
Summary: The study aimed to evaluate the effects of vitamin D alone or in combination with teriparatide on peri-implant bone tissue in orchiectomized rats. Through an in vivo study, it was found that treatment with vitamin D and teriparatide together can increase the volume of bone tissue around the implant and improve bone quality. However, given the increasing population with bone metabolism disorders seeking dental implant rehabilitation treatment, the verification of medications that promote an increase in bone density is essential.
Article
Biochemistry & Molecular Biology
Denise Weffort, Leticia F. Adolpho, Alann T. P. Souza, Gileade P. Freitas, Helena B. Lopes, Fabiola S. Oliveira, Rayana L. Bighetti-Trevisan, Leticia Pitol-Palin, Doris H. Matsushita, Roberta Okamoto, Marcio M. Beloti, Adalberto L. Rosa
Summary: Type 1 (T1DM) and type 2 (T2DM) diabetes mellitus affect glucose metabolism and cause bone damage through various mechanisms, including the impact on osteoblasts. This study examined the osteoblast differentiation of mesenchymal stem cells (MSCs) from rats with T1DM or T2DM and the effects of removing hyperglycemia on the osteogenic potential of these cells. The results showed that both T1DM and T2DM inhibited the osteoblast differentiation of MSCs cultured in hyperglycemic media, with T1DM having a more significant effect. Restoring normoglycemic conditions partially recovered the osteogenic potential of MSCs from rats with T1DM but not with T2DM. These findings highlight the need for targeted therapies for T1DM- or T2DM-induced bone loss, as both conditions disrupt osteoblast differentiation at different levels and likely through different mechanisms.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eduardo Dallazen, Gabriela Cristina Baccaro, Anderson Maikon de Souza Santos, Mariana Elias Queiroz, Joel Ferreira Santiago Junior, Eduardo Hochuli-Vieira, Leonardo Faverani
Summary: This study aimed to compare 2D and 3D methods used in the assessment of postoperative edema. The results showed that digital measuring methods demonstrated greater homogeneity than the manual method in analyzing facial distortions caused by swelling simulation, suggesting that digital methods may be more reliable for assessing facial edema.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Dimitra Athanasiadou, Nadeen Meshry, Naara G. Monteiro, Ana C. Ervolino-Silva, Ryan Lee Chan, Christopher A. McCulloch, Roberta Okamoto, Karina M. M. Carneiro
Summary: DNA-based biomaterials have potential as biodegradable scaffolds for bone repair due to their ability to bind Ca2+ and promote HAP growth. This study describes the design and synthesis of DNA hydrogels, their interactions with osteogenic cell lines, and their promotion of new bone formation in rat calvarial wounds.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Polymer Science
Lilian Caldas Quirino, Pedro Henrique de Azambuja Carvalho, Renato Torres Augusto Neto, Cassio Amaro Comachio, Naara Gabriela Monteiro, Ana Claudia Ervolino-Silva, Roberta Okamoto, Valfrido Antonio Pereira-Filho
Summary: This study evaluated the bone repair in critical defects using a polydioxanone membrane (Plenum((R)) Guide) and a collagen-based membrane (Bio-Gide((R))) in rats. The results showed that the Plenum((R)) Guide group had better bone regeneration and gene expression, but there was no significant difference between the two groups in histometric and micro-CT analyses. Therefore, the absorbable polydioxanone membrane is an effective guided bone regeneration membrane.
Article
Engineering, Biomedical
Leonardo P. Faverani, Sarah Hashemi Astaneh, Monique Goncalves da Costa, Leonardo A. Delanora, Tiburtino J. Lima-Neto, Stefany Barbosa, Maretaningtias Dwi Ariani, Christos Takoudis, Cortino Sukotjo
Summary: This study aimed to evaluate the effect of functionalization of collagen membranes on bone repair of critical defects in rat calvaria and subcutaneous biocompatibility. The results showed that collagen membranes treated with atomic layer deposition of TiO2 for 150 cycles exhibited better bioactive potential in the process of defect repair.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Cell Biology
Debora de Souza Ferreira Savio, Lucia Moitrel Pequeno da Silva, Gabriel Guerra David Reis, Ricardo Junior Denardi, Natacha Malu Miranda da Costa, Flavia Aparecida Chaves Furlaneto, Sergio Luis Scombatti de Souza, Carlos Fernando de Almeida Barros Mourao, Richard J. Miron, Roberta Okamoto, Michel Reis Messora
Summary: After tooth loss, bone remodeling can cause significant decreases in bone height and thickness, which can compromise the success of dental implants. Leukocyte-platelet-rich fibrin (L-PRF) has shown potential in promoting tissue regeneration and several protocols have been proposed to improve its regenerative potential. In this study, different centrifugation protocols were evaluated for their effectiveness in bone healing in rat calvaria defects. The results showed that platelet aggregates, especially with horizontal centrifugation, improve bone neoformation and have more biological potential for bone healing.
Review
Critical Care Medicine
J. C. Cruz, C. K. Martins, J. E. V. Piassi, I. R. Garcia Junior, J. F. Santiago Junior, L. P. Faverani
Summary: The study aimed to investigate the efficacy of chlorhexidine in preventing ventilator-associated pneumonia (VAP). A systematic review and meta-analysis were conducted, and data were obtained from Pubmed, Cochrane Library, and EMBASE. Ten randomized clinical trials involving 1233 mechanically ventilated patients were included. Results showed that oral application of chlorhexidine reduced the incidence of VAP, but the evidence quality for mortality rates was very low.
MEDICINA INTENSIVA
(2023)
Article
Engineering, Biomedical
Gabriel Mulinari-Santos, Jaqueline Silva dos Santos, Igor Lebedenco Kitagawa, Fabio Roberto de Souza Batista, Paulo Roberto Botacin, Cristina Antoniali, Paulo Noronha Lisboa-Filho, Roberta Okamoto
Summary: Hypertension and estrogen deficiency can impair osseointegration, and the use of antihypertensive drugs and alendronate sodium can enhance bone healing. However, estrogen deficiency still affects bone integration even with alendronate coating.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Soumya Saha, Raphael Cavalcante Costa, Mirela Caroline Silva, Joao Matheus Fonseca-Santos, Lin Chen, Abhijit H. Phakatkar, Harshdeep Bhatia, Leonardo P. Faverani, Valentim A. R. Barao, Tolou Shokuhfar, Cortino Sukotjo, Christos Takoudis
Summary: A novel method using room-temperature atomic layer deposition (ALD) to coat collagen membranes with MgO is reported in this study. The MgO-coated collagen membranes show excellent chemical nature, surface topography, and biological properties, making them promising candidates for guided bone regeneration.
BIOACTIVE MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Carolina Mendonca de Almeida Malzoni, Elton Carlos Pichotano, Luiz Guilherme Freitas de Paula, Ricardo Violante de Souza, Roberta Okamoto, Rupert S. Austin, Elcio Marcantonio Jr, Rafael Scaf de Molon, Daniela Leal Zandim-Barcelos
Summary: The combination of leukocyte and platelet-rich fibrin (L-PRF) and deproteinized bovine bone mineral (DBBM) was found to enhance bone regeneration and improve implant stability in maxillary sinus augmentation procedures, allowing for faster implant placement.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
William Phillip Pereira Da Silva, Leonardo Alan Delanora, Barbara Ribeiro Rios, Maria Eloise de Sa Simon, Cortino Sukotjo, Leonardo P. Faverani
Summary: This study compared senile rats (SENIL) with young ovariectomized rats (OXV) to select a critical animal model for assessing bone repair with implant installation. The results showed that the SENIL group had lower cell viability, more critical gene expression, lower alkaline phosphatase activity, and mineralization nodules. In vivo histometric and biomechanical analysis also indicated inferior bone condition in the SENIL group. Confocal microscopy revealed fragile bones in the SENIL group. Microtomography results were similar between the groups. These findings suggest that the senile model can provide a more critical bone condition for investigating biomaterial properties and topographic changes.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Engineering, Biomedical
Tarik Ocon Braga Polo, Joao Matheus Fonseca-Santos, Gustavo Antonio Correa Momesso, William Phillip Pereira da Silva, Stefany Barbosa, Anderson Maikon de Souza Santos, Mirela Caroline Silva, Valdir Gouveia Garcia, Leticia Helena Theodoro, Leonardo P. Faverani
Summary: This study evaluated the effects of infrared laser (IRL) on bone repair in rats with ovariectomies. The results showed that IRL increased bone turnover and promoted new bone formation, especially in rats with low bone mineral density. These findings suggest that IRL could be used intraoperatively to optimize bone repair.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bruna Kaori Namba Inoue, Laura Vidoto Paludetto, Naara Gabriela Monteiro, Fabio Roberto de Souza Batista, Igor Lebedenco Kitagawa, Roberto Santana da Silva, Cristina Antoniali, Paulo Noronha Lisboa Filho, Roberta Okamoto
Summary: Postmenopausal osteoporosis and poor dietary habits can lead to overweightness and obesity. This study found that nitric oxide has the potential to improve peri-implant conditions, especially at low concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ana Flavia Piquera Santos, Lara Cristina Cunha Cervantes, Roberta Okamoto, Antonio Carlos Guastaldi, Thallita Pereira Queiroz, Layla Panahipour, Reinhard Gruber, Francisley avila Souza
Summary: This study investigated the effect of surface modifications on osteogenic and stromal cells. The results showed that laser treatment enhanced the hydrophilicity of titanium surface, while hydroxyapatite coating reduced cell viability and induced the release of inflammatory cytokines.
APPLIED SCIENCES-BASEL
(2023)
