Article
Biochemistry & Molecular Biology
Cao Van Anh, Joo-Hee Kwon, Jong Soon Kang, Hwa-Sun Lee, Chang-Su Heo, Hee Jae Shin
Summary: Chemical investigation of the ethyl acetate extract from the culture broth of marine-derived actinobacterium Streptomyces ardesiacus 156VN-095 led to the discovery of three previously unknown angucycline glycosides, including one compound with significant cytotoxicity against cancer cells. These findings highlight the potential of angucycline glycosides as leading structures for the development of new anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Fuhang Song, Jiansen Hu, Xinwan Zhang, Wei Xu, Jinpeng Yang, Shaoyong Li, Xiuli Xu
Summary: Two new cyclized thiolopyrrolone derivatives and one known compound were identified from a marine-derived Streptomyces sp. They exhibited antibacterial activities against different bacteria with varying minimum inhibitory concentrations.
Article
Plant Sciences
Miao Jiang, Ying Zhang, Yuxiao Zhang, Zhongjun Ma, Jinhui Wang
Summary: Thirteen new compounds were identified from marine-derived Streptomyces sp. ZSN77, with some exhibiting potential anti-cancer and anti-inflammatory activities in vitro and in vivo.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Ming Gao, Sang Bong Lee, Jae-Eon Lee, Geum Jin Kim, Jimin Moon, Joo-Won Nam, Jong-Sup Bae, Jungwook Chin, Yong Hyun Jeon, Hyukjae Choi
Summary: In this study, seven butenolide compounds were discovered and isolated, and their structures were determined. Compounds 1-6 showed potential anti-inflammatory activities.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
You-Ying Chen, Lo-Yun Chen, Po-Jen Chen, Mohamed El-Shazly, Bo-Rong Peng, Yu-Cheng Chen, Chun-Han Su, Jui-Hsin Su, Ping-Jyun Sung, Pei-Tzu Yen, Lung-Shuo Wang, Kuei-Hung Lai
Summary: This study identified anti-leukemic metabolites from marine-derived bacteria, with the fermentation broth extract of Streptomyces sp. LY1209 showing potent anti-proliferative effects against acute lymphoblastic leukemia cells. The major constituents were staurosporine and a series of diketopiperazines (DKPs), including a novel DKP, which were identified for the first time in nature.
Article
Plant Sciences
Kunyu Xia, Hui Luo, Rui Ma, Rongxin Zhang, Weiming Zhu, Peng Fu
Summary: Four new aromatic polyketides and two new hydroxamate siderophores were isolated from a marine-algae-derived Streptomyces strain, showing unique structures and the ability to bind Fe(III). One of the compounds was found to form a tighter Fe(III) complex compared to deferoxamine B mesylate.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Veterinary Sciences
Yunwen Bi, Ganxing Liu, Qiushi Yu, Qiting Liang, Zhongheng Xu, Miao Cui, Qizhong Zhang, Delin Xu
Summary: This study showed that Marine Streptomyces S073 employs multifaceted strategies, including DBP-mediated antagonism and siderophore-governed iron competition, to achieve Vibrio inhibition. DBP plays a crucial role in driving the anti-Vibrio activity in the metabolites pool of S073.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Applied
Hongbo Huang, Yongxiang Song, Ruochen Zang, Xin Wang, Jianhua Ju
Summary: In this study, a novel butenolide derivative was isolated from marine-derived Streptomyces koyangensis SCSIO 5802, showing mild antiviral activity against herpes simplex virus. The structure of the compound was elucidated through spectral data analysis, and its stereo configuration was determined by comparison with known compounds.
NATURAL PRODUCT RESEARCH
(2021)
Article
Microbiology
Tongxu Cui, Simin Lin, Zizhen Wang, Peng Fu, Cong Wang, Weiming Zhu
Summary: Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F-H (1-3) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380. These compounds showed a selective antiproliferation effect on the acute myeloid leukemia cell line MV4-11.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Organic
Byeoung-Kyu Choi, Duk-Yeon Cho, Dong-Kug Choi, Hee Jae Shin
Summary: A new type of natural products, miharadienes A-D, was isolated from marine-derived Streptomyces and their structures were elucidated using various techniques. Miharadiene D exhibited moderate inhibitory effect on nitric oxide production in stimulated microglia cells.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Hui Zhang, Xiaohan Ren, Haiju Xu, Huan Qi, Shihua Du, Jun Huang, Ji Zhang, Jidong Wang
Summary: Two previously unknown pyrrolizine alkaloids, phenopyrrolizins A and B, were discovered from marine-derived Micromonospora sp. HU138. Their structures were determined through extensive spectroscopic analysis and the racemization mechanism of one compound was proposed. Antifungal activity testing showed that one of the compounds exhibited inhibition against the mycelial growth of Botrytis cinerea.
Article
Chemistry, Medicinal
Zhikai Guo, Shiying Ma, Salman Khan, Hongjie Zhu, Bo Zhang, Shiqing Zhang, Ruihua Jiao
Summary: Marine-derived Streptomyces sp. ITBB-ZKa6 led to the discovery of two unique antimycin-type depsipeptides, zhaoshumycins A and B, along with four known neoantimycins. The structures of the new compounds were elucidated based on diverse spectroscopic data and biogenetic consideration. Further structure-activity relationship analysis suggested the importance of certain functional groups for cytotoxicity in MCF7 cells.
Article
Plant Sciences
Kantinan Leetanasaksakul, Wilaiwan Koomsiri, Takuya Suga, Hirotaka Matsuo, Rei Hokari, Pakorn Wattana-Amorn, Yoko Takahashi, Kazuro Shiomi, Takuji Nakashima, Yuki Inahashi, Arinthip Thamchaipenet
Summary: Sattahipmycin is a novel polycyclic xanthone isolated from marine-derived Streptomyces sp. GKU 257-1, which exhibits antibiofilm, antibacterial, and anticancer activities.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Lin Guo, Qiaoli Yang, Guangfei Wang, Shumin Zhang, Ming Liu, Xiaohong Pan, Gennaro Pescitelli, Zeping Xie
Summary: The study identified three new members of angucyclinones, among which actetrophenol A (2) exhibited significant antibiotic activity against multi-drug resistant bacteria.
FRONTIERS IN CHEMISTRY
(2021)
Article
Microbiology
Kusuma Buangrab, Makamas Sutthacheep, Thamasak Yeemin, Enjuro Harunari, Yasuhiro Igarashi, Paranee Sripreechasak, Pawina Kanchanasin, Somboon Tanasupawat, Wongsakorn Phongsopitanun
Summary: Two new marine actinobacteria, belonging to the genus Streptomyces and Kineosporia, respectively, were isolated from a coral collected in Thailand. These strains showed high similarity to known strains but had distinct morphological and chemotaxonomical characteristics. Comparative genome analysis revealed significant differences between these strains and closely related species, leading to the proposal of two new species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
