Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

White tea (Camellia sinensis) inhibits proliferation of the colon cancer cell line, HT-29, activates caspases and protects DNA of normal cells against oxidative damage

(2015) Fatemeh Hajiaghaalipour et al.   FOOD CHEMISTRY

Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention

(2014) Samriddhi Shukla et al.   CANCER LETTERS

1α,25-Dihydroxyvitamin D3 inhibits cell growth and NFκB signaling in tamoxifen-resistant breast cancer cells

(2014) Johan Lundqvist et al.   STEROIDS

Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells

(2013) Chia-Han Lin et al.   BMC Complementary and Alternative Medicine

The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells

(2013) Radim Havelek et al.   PHYTOMEDICINE

Cyathula prostrata ethanol extract activates the extrinsic pathway of apoptosis in HeLa and U937 cell lines

(2013) G.E. Schnablegger et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway

(2013) VGM Naidu et al.   Asian Pacific Journal of Tropical Medicine

Effect of extracts from Phyllanthus watsonii Airy Shaw on cell apoptosis in cultured human breast cancer MCF-7 cells

(2012) Sujatha Ramasamy et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Alantolactone induces activation of apoptosis in human hepatoma cells

(2012) Jia-Chuan Lei et al.   FOOD AND CHEMICAL TOXICOLOGY

Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway

(2012) Yan Qiao et al.   FOOD AND CHEMICAL TOXICOLOGY

Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh

(2012) Hyeonji Kim et al.   FOOD CHEMISTRY

Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells

(2012) Roberto Gambari et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bryonia dioica aqueous extract induces apoptosis through mitochondrial intrinsic pathway in BL41 Burkitt's lymphoma cells

(2012) Bachir Benarba et al.   JOURNAL OF ETHNOPHARMACOLOGY

(−)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation

(2012) Murli Manohar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells

(2012) Hye-Sook Seo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Luffa echinata Roxb. Induces Human Colon Cancer Cell (HT-29) Death by Triggering the Mitochondrial Apoptosis Pathway

(2012) Li-Hua Shang et al.   MOLECULES

Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

(2012) Ching-Yu Yen et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A

(2012) Syam Mohan et al.   PHYTOMEDICINE

The role of mitochondria in apoptosis

(2011) Seon-Yong Jeong et al.   BMB Reports

Activation of apoptosis by ethyl acetate fraction of ethanol extract of Dianthus superbus in HepG2 cell line

(2011) Jian-Qing Yu et al.   Cancer Epidemiology

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Effects of Ficus hirta Vahl. (Wuzhimaotao) extracts on growth inhibition of HeLa cells

(2011) You-wei Zeng et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis

(2011) K.N. Chidambara Murthy et al.   FOOD AND CHEMICAL TOXICOLOGY

Induction of apoptosis and cell cycle arrest by pericarp polyphenol-rich extract of Baneh in human colon carcinoma HT29 cells

(2011) Parisa Fathi Rezaei et al.   FOOD AND CHEMICAL TOXICOLOGY

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

(2011) Ke Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Typhonium blumei extract inhibits proliferation of human lung adenocarcinoma A549 cells via induction of cell cycle arrest and apoptosis

(2011) Hsia-Fen Hsu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells

(2011) Qiong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-κB activity

(2011) Ju Hoon Oh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression

(2011) Jingping Sun et al.   LEUKEMIA RESEARCH

Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

(2011) Sutapa Mahata et al.   Molecular Cancer

Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma

(2011) Thayele Hamsa et al.   Chinese Medicine

Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells

(2010) Xiaolan Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

(2010) Ho-Keun Kwon et al.   BMC CANCER

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

(2010) Limin Shu et al.   CANCER AND METASTASIS REVIEWS

Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB

(2010) Xin Li et al.   CANCER LETTERS

Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway

(2010) Songgang Li et al.   CANCER LETTERS

Casearin X exhibits cytotoxic effects in leukemia cells triggered by apoptosis

(2010) Paulo M. Pinheiro Ferreira et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells – Involvement of ROS generation and polyamine depletion

(2010) Lan Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

The chloroform fraction of guava (Psidium cattleianum sabine) leaf extract inhibits human gastric cancer cell proliferation via induction of apoptosis

(2010) Jeong Yong Moon et al.   FOOD CHEMISTRY

Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells

(2010) Yu-Feng Kuo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract

(2010) P. Ovadje et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

(2010) Rajiv R. Ratan et al.   JOURNAL OF NEUROCHEMISTRY

Reactive Oxygen Species-Dependent Apoptosis by Gugulipid Extract of Ayurvedic Medicine Plant Commiphora mukul in Human Prostate Cancer Cells Is Regulated by c-Jun N-Terminal Kinase

(2010) D. Xiao et al.   MOLECULAR PHARMACOLOGY

Cancer Chemopreventive Activity of Maslinic Acid: Suppression of COX-2 Expression and Inhibition of NF-κB and AP-1 Activation in Raji Cells

(2010) Yap Hsum et al.   PLANTA MEDICA

In vitro antiproliferative and antiangiogenic effects of synthetic chalcone analogues

(2010) Martina Pilatova et al.   TOXICOLOGY IN VITRO

Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa

(2010) Harish Chandra Pal et al.   TOXICOLOGY IN VITRO

Propolis from Turkey induces apoptosis through activating caspases in human breast carcinoma cell lines

(2009) H. Seda Vatansever et al.   ACTA HISTOCHEMICA

Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells

(2009) Yanfeng Xu et al.   CANCER LETTERS

Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells

(2009) Huei-Mei Chen et al.   CANCER LETTERS

Butein induces G2/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation

(2009) Dong-Oh Moon et al.   CANCER LETTERS

Inhibition of Activator Protein-1 by Sulforaphane Involves Interaction with Cysteine in the cFos DNA-Binding Domain: Implications for Chemoprevention of UVB-Induced Skin Cancer

(2009) S. E. Dickinson et al.   CANCER RESEARCH

Supercritical carbon dioxide extract of Physalis peruviana induced cell cycle arrest and apoptosis in human lung cancer H661 cells

(2009) Shu-Jing Wu et al.   FOOD AND CHEMICAL TOXICOLOGY

Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells

(2009) Seyed Hadi Mousavi et al.   FOOD AND CHEMICAL TOXICOLOGY

Perspectives for Cancer Prevention With Natural Compounds

(2009) A.R.M. Ruhul Amin et al.   JOURNAL OF CLINICAL ONCOLOGY

Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo

(2009) Kai-Hong Xu et al.   LEUKEMIA RESEARCH

Berberine and a Berberis lycium extract inactivate Cdc25A and induce α-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis

(2009) Musa Khan et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus

(2009) Qiaojuan Yan et al.   PHYTOMEDICINE

Morusin induces apoptosis and suppresses NF-κB activity in human colorectal cancer HT-29 cells

(2008) Jenq-Chang Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathway

(2008) Bo Liu et al.   CANCER LETTERS

Caspases — An update

(2008) Indrajit Chowdhury et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

(−)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells

(2008) Chung-Yi Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa

(2008) Eun Ji Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line – RPMI 8226

(2008) Pasupuleti Sreenivasa Rao et al.   FOOD AND CHEMICAL TOXICOLOGY

Induction of apoptosis in U937 human leukaemia cells by the hexane fraction of an extract of immature Citrus grandis Osbeck fruits

(2008) Hee-Kyung Lim et al.   FOOD CHEMISTRY

Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells

(2008) Faisal Thayyullathil et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells

(2008) K.A. Manu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Elesclomol induces cancer cell apoptosis through oxidative stress

(2008) J. R. Kirshner et al.   MOLECULAR CANCER THERAPEUTICS

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Apoptosis induction by 4-nerolidylcatechol in melanoma cell lines

(2008) C.A. Brohem et al.   TOXICOLOGY IN VITRO

Aqueous extract of Rhodiola imbricata rhizome inhibits proliferation of an erythroleukemic cell line K-562 by inducing apoptosis and cell cycle arrest at G2/M phase

(2007) K.P. Mishra et al.   IMMUNOBIOLOGY

Food bioactives, apoptosis, and cancer

(2007) Min-Hsiung Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH